Image 5_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…</p>Discussion<p>Our findings demonstrated that the analgesic benefit of (2R,6R)-Hydroxynorketamine is dose dependent, protein analysis suggests that (2R,6R)-HNK analgesic is associated with augmenting GluA1, GluA2, CaMKII, Kv2.1 and a reduction in BDNF protein ratios in hippocampus, decreased spinal cord c-Fos and reduced BNDF at the dorsal root ganglion. (2R,6R)-Hydroxynorketamine also augmented meloxicam analgesia in disk puncture mice. …”

Data Sheet 1_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Discussion<p>Our findings demonstrated that the analgesic benefit of (2R,6R)-Hydroxynorketamine is dose dependent, protein analysis suggests that (2R,6R)-HNK analgesic is associated with augmenting GluA1, GluA2, CaMKII, Kv2.1 and a reduction in BDNF protein ratios in hippocampus, decreased spinal cord c-Fos and reduced BNDF at the dorsal root ganglion. (2R,6R)-Hydroxynorketamine also augmented meloxicam analgesia in disk puncture mice. …”

Data Sheet 4_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Discussion<p>Our findings demonstrated that the analgesic benefit of (2R,6R)-Hydroxynorketamine is dose dependent, protein analysis suggests that (2R,6R)-HNK analgesic is associated with augmenting GluA1, GluA2, CaMKII, Kv2.1 and a reduction in BDNF protein ratios in hippocampus, decreased spinal cord c-Fos and reduced BNDF at the dorsal root ganglion. (2R,6R)-Hydroxynorketamine also augmented meloxicam analgesia in disk puncture mice. …”

Adenylate Cyclase (AC) activity is reduced in DYT1 dystonia patient fibroblast cells. by Jin A. Cho (656426)

“…<p>(A) A 2.5-fold reduction (*P<0.05; one-way ANOVA and Tukey's post hoc comparison, n = 3 experiments) in the cAMP accumulation was observed by DYT1 patient fibroblast cell lines (6 cell lines represented in black 7–12: GM02306, GM02551, GM3208, GM03211, FFF13111983, HF48) compared to healthy fibroblast cell lines (6 cell lines represented in white 1–6: GM00023, GM00024, GM01651, GM02902, HF6, HF19) in response to forskolin (10 µM). …”

Reverse transcription-polymerase chain reaction analysis showing a strong decrease in clusterin RNA after treatment with antisense oligodeoxynucleotides to clusterin (ODNclu) in the MDA-MB-231 and MCF-7 cell lines by Maximino Redondo (87169)

DataSheet1_Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.docx by Shukun Sun (11510686)

“…Moreover, the alleviating effects of ADK inhibition on ER stress, inflammation, and cell necroptosis were eliminated by the adenosine A_2A receptor antagonist.</p><p>Conclusion: ADK inhibition reduced inflammation and necroptotic acinar cell death in SAP via the adenosine A_2A receptor/ER stress pathway, suggesting that ADK might be a potential therapeutic target for SAP.…”

Hemoglobin A1c Levels and Risk of Severe Hypoglycemia in Children and Young Adults with Type 1 Diabetes from Germany and Austria: A Trend Analysis in a Cohort of 37,539 Patients be... by Beate Karges (640991)

“…Based on advances in diabetes technology and pharmacotherapy, we hypothesized that the inverse association between severe hypoglycemia and HbA1c has decreased in recent years.…”

Signal intensity plots from knockdown data for StAR (A) and CYP19A (B). by Roseanne Rosario (130971)

“…CYP19A, usually activated by FOXL2 shows a significant decrease (p = 0.03) in expression following the knockdown of mutant FOXL2. …”

<i>SpdA-ins</i> cells adhere more efficiently than WT cells to their substrate. by Marco Dias (290981)

“…A decrease in cell detachment can be the result of an increase in the adhesion force (F) or of a decrease in h (i.e. of a more efficient cell spreading).…”

Regions (α-helices, β-sheets, and loops) showing an average increase or decrease of RMSF in the MTs compared to the WT; RMSF of a particular structure is taken to be increased or decreased if there is an average change in RMSF of >0.03 nm in at least ≥50% of its residues. by Kumaraswamy Naidu Chitrala (612025)

“…<p>Regions (α-helices, β-sheets, and loops) showing an average increase or decrease of RMSF in the MTs compared to the WT; RMSF of a particular structure is taken to be increased or decreased if there is an average change in RMSF of >0.03 nm in at least ≥50% of its residues.…”

High-Throughput Blood Plasma Extraction in a Dimension-Confined Double-Spiral Channel by Shaofei Shen (680440)

“…Herein, we introduce a dimension-confined microfluidic device featuring a double-spiral channel designed to regulate secondary flows, thereby enabling high-throughput isolation of blood for plasma extraction. …”

Both JMJD1A and BACH1 were the direct targets of miR-155. by Zi-Ming Du (223324)

“…Pairing of miR-155 with JMJD1A 3′UTR region. (C). Overexpression of miR-155 by the miR-155 mimic resulted in a significant decrease in luciferase signals of pMIR-report-JMJD1A 3′UTR (JMJD1A) and pMIR-report-BACH1 3′UTR (BACH1) transfected HEK 293 cells, but not in pMIR-report-vector (vector) transfected HEK 293 cells.…”

Characteristic Features of CO₂ and CO Adsorptions to Paddle-Wheel-type Porous Coordination Polymer by Jia-Jia Zheng (1480219)

“…For all cases, the exchange repulsion with the organic linker decreases to a larger extent than the attractive electrostatic and dispersion interactions decrease when going from the normal position to the deviating one. …”

Effects of HP1a depletion on focal movement. by Raghuvar Dronamraju (204100)

“…The western blot shows a decrease in the level of HP1a, but not HP1b or -c. …”

Whole brain activation as a function of illness course. by Maggie M. Sweitzer (3167943)

Chronic <i>T</i>. <i>muris</i> infection affects the composition of the microbiota. by Jacob Bak Holm (734935)

Splicing to include exon 3a is a developmentally regulated event in skeletal muscle. by Meghan C. Drummond (466384)

“…(<b>B</b>) qPCR of RNA harvested in Trizol showed that concurrent with a decrease in normal <i>Actg1</i>, splicing to generate alternative <i>Actg1</i> increases during differentiation into myotubes. …”

Zircon U–Pb and Hf – isotopes from the eastern part of the Sveconorwegian Orogen, SW Sweden: implications for the growth of Fennoscandia by Andreas Petersson (2841959)

“…Archaean reworking decreases between 1.9 and 1.7 Ga and a mixed Svecofennian crustal reservoir is generated. …”

The effect of G1613A mutations on the levels of HBsAg and HBeAg. by Man-Shan Li (347605)

“…<p>(<b>A</b>) Intracellular level of HBsAg, (<b>B</b>) extracellular level of HBsAg, (<b>C</b>) intracellular level of HBeAg and (<b>D</b>) extracellular level of HBeAg were measured after transfection with 1.3× HBV genomes with indicated mutations into HuH7 cells by ELISA as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021856#s2" target="_blank">materials and methods</a>. …”

Mass spectrometric analyses for crystallins. by Akosua K. Boateng (21672931)

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