Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment by Yang Liu (4829)

“…However, currently, the biological function of IGF2BP1 in regulating the TIME is not well-understood. In this study, we report that IGF2BP1 knockdown induces cancer cell apoptosis, thereby significantly not only activating immune cell infiltration including CD4⁺, CD8⁺ T cells, CD56⁺ NK cells, and F4/80⁺ macrophage but also decreasing PD-L1 expression in hepatocellular carcinoma (HCC). …”

Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment by Yang Liu (4829)

“…However, currently, the biological function of IGF2BP1 in regulating the TIME is not well-understood. In this study, we report that IGF2BP1 knockdown induces cancer cell apoptosis, thereby significantly not only activating immune cell infiltration including CD4⁺, CD8⁺ T cells, CD56⁺ NK cells, and F4/80⁺ macrophage but also decreasing PD-L1 expression in hepatocellular carcinoma (HCC). …”

Mechanoresponsive Spin via Spin–Lattice Coupling in Organic Cocrystals by Zhiyan Chen (6369101)

“…Through decreasing temperature or applying external electric field, the electron–phonon coupling coefficient presents a decreasing tendency, which will affect the dipole and dielectric constant in the allotropic crystals differently.…”

Mechanoresponsive Spin via Spin–Lattice Coupling in Organic Cocrystals by Zhiyan Chen (6369101)

“…Through decreasing temperature or applying external electric field, the electron–phonon coupling coefficient presents a decreasing tendency, which will affect the dipole and dielectric constant in the allotropic crystals differently.…”

Mirn23a regulates essential B cell promoting genes to sustain commitment to the B cell lineage. by Jeffrey L. Kurkewich (3044211)

“…<p>To evaluate targets of mirn23a that could promote sustained commitment towards the B cell lineage downstream of the MPP, we overexpressed empty vector control (MSCV) or the mirn23a cluster (MSCV-23a27a24) into 70Z/3 Pre-B cells and evaluated gene expression by qRT-PCR. …”

Innovation, nightlights and a continuous measure of city size. by Saul Estrin (8629173)

HilD-activation results in a growth defect. by Doaa Osama Saleh (16353149)

“…Representative images are shown in the right panel. the same strains as in (A) were analysed. (C) Time-lapse microscopy analysis reveals a decreased cell elongation rate (left), a decrease in the maximal cell length (middle) as well as decreased length elongation during a division cycle (right) upon HilD induction. …”

Comparison of hatched blastocyst rates in Groups A and B. by Ayaka Fujishima (21221913)

Lack of i6A37 is not responsible for <i>maf1-</i>antisuppression phenotype. by Aneeshkumar G. Arimbasseri (840654)

Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer - Fig 4 by Nivedita Arora (3743413)

“…</b> Treatment with 100nM triptolide decreased the mRNA expression of Sp1, HSF1 and HSP70 in MKN28 and MKN45 gastric adenocarcinoma cells in a time (24–48 hours) dependent manner. …”

Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer - Fig 1 by Nivedita Arora (3743413)

“…</b> Treatment of moderately differentiated gastric adenocarcinoma cell line, MKN28 with triptolide decreases viability in a dose (25–100nM) as well as time (24–72 hours) dependent manner. …”

AoA results. by Eric Williams (101567)

“…Speech samples produced by 12 pwAD and 12 controls for the Carolinas Conversations Collection were analysed for noun, verb and pronoun counts and ratios, lexical diversity overall and among nouns and verbs, copula use, and frequencies and ages of acquisition (AoA) of nouns and verbs produced. pwAD used fewer nouns and a narrower range of words than controls, exhibiting signs of increased reliance on pronouns and decreased noun diversity. …”

Bmi1 Loss in the Organ of Corti Results in p16^ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors <i>In Vitro</i> by Mohamed Bassiouni (3226770)

“…The cell cycle inhibitor p16^ink4a has been previously identified as a downstream target of Bmi1. …”

Statistics of three drug combination datasets were listed, including the number of drugs, principal drugs, adjuvant drugs, known synergistic combinations (A), and drug pairs withou... by Xing Chen (140292)

Protective effects of 0.2 μM cyclosporine A (CsA) on the sensitivity of mPTP opening under de-energized conditions. by Gonçalo C. Pereira (9022700)

Table 2_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx by Lei Zhang (38117)

“…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …”

Table 6_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx by Lei Zhang (38117)

“…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …”

Table 3_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx by Lei Zhang (38117)

“…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …”

Table 1_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx by Lei Zhang (38117)

“…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …”

Table 5_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx by Lei Zhang (38117)

“…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …”