25 Years of Small-Molecule Optimization at Novartis: A Retrospective Analysis of Chemical Series Evolution by Maximilian Beckers (3838951)

“…This emphasizes the heavy-atom count and log <i>D</i> as important parameters to monitor, especially as we further show that the decrease in permeability can be explained with the increase in molecular size. …”

ANXA1 decreased p-ERK1/2 accumulation in the nucleus and decreased cyclin D1 expression in PASMCs. by Jing He (58446)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis by Jamialahamdi, Tannaz

“…Background: Obesity is a chronic inflammatory condition and this meta-analysis evaluated the impact of bariatric surgery on SAA. …”
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Proteins enriched in the proximity-ome of Vpu-S52,56N relative to wild type: Vpu-mediated and serine-dependent decreases in steady-state expression. by Charlotte A. Stoneham (10819125)

“…<p>(A) HEK293T cells were co-transfected with target cDNAs and plasmids expressing WT Vpu or Vpu-S52,56N. …”

<i>Cebpd−/−</i> mice had increased apoptosis and mitotic index and decreased levels of γ-H2AX in intestinal crypts, post-TBI. by Snehalata A. Pawar (586961)

shRNA-mediated knockdown of syntaxin-4 (Syn4) decreases expression of KCa2.3 at the plasma membrane (PM) in HeLa cells. by Claudia A. Bertuccio (309866)

“…Knockdown of Syn4 was confirmed by immunoblot (bottom blot and panel <b>(D)</b>). Tubulin was used as a loading control. Knockdown of Syn4 resulted in a decreased PM expression of KCa2.3 (top blot and panel <b>(B)</b>), whereas total KCa2.3 expression was unaffected (middle blot and panel <b>(C)</b>). …”

The small molecule rhodomyrtone suppresses TNF-α and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis by Julalak Chorachoo (5855852)

“…This study assessed the potential of rhodomyrtone for curtailing TNF/IL-17A-driven inflammation. Stimulating human skin organ cultures with TNF+IL-17A to model the skin inflammation in psoriasis, we found that rhodomyrtone significantly decreased inflammatory gene expression and the expression and secretion of inflammatory proteins, assessed by qRT-PCR, immunohistochemistry and ELISA assays respectively. …”

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity by Hadjer Brihoum (5383178)

“…A histological analysis further supported these findings and showed a decrease in the number of side effects. …”

Spatial training decreases the association between Ndfip1 and Nedd4 and decreases endogenous Beclin 1 ubiquitination in the hippocampus. by Wei-Lun Hsu (1756123)

“…<p><b>(A)</b> The CA1 tissue lysates from non-trained and trained rats were immunoprecipitated with IgG and immunoblotted with anti-Nedd4 and anti-Ndfip1 antibodies to serve as the control group. …”

Zeólita NaA sintetizada sobre fibra de vidro como estratégia para otimização do abrandamento de águas duras by Edipo S Oliveira (12703399)

“…The sample maintained this performance in a wide range of pH (3.0-9.0), and also presented a feasible regenerability, with no decrease in its performance during the first four cycles of use, reaching 87.3% of efficiency over the tenth cycle.…”

Myelinopathy results in a significantly reduced spike probability and increased latency after a release event. by Maral Budak (6680351)

Space-time plot of the response to an external perturbation at <i>t</i> = 40, that decreases the stability of <i>NMIIA</i> by a 2-fold increase of its decay rate and at the same time the contractility of <i>NMIIA</i> is switched off (i.e.... by Rashmi Priya (159985)

Intravital microscopy video in a baseline mouse of the central vein and liver sinusoids. by Fong Wilson Lam (9515038)

Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection by Tiffany Hensley-McBain (4872715)

“…We report that increased neutrophil survival contributes to neutrophil accumulation in colorectal biopsy tissue, thus implicating neutrophil lifespan as a new therapeutic target for mucosal inflammation in HIV infection. …”

Image_3_Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner.TIF by Keyana N. Porter (8679852)

“…To assess the effect of progestins on MMP-9 and amyloid-beta, in vitro, C6 rat glial cells were exposed to MPA for 48 h and then the enzymatic, secretory, and amyloid-beta degrading capacity of MMP-9 was assessed from the conditioned culture medium. We found that MPA treatment inhibited transcription of MMP-9, which resulted in a subsequent decrease in the production and secretion of MMP-9 protein, in part through the glucocorticoid receptor. …”

Image_1_Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner.TIF by Keyana N. Porter (8679852)

“…To assess the effect of progestins on MMP-9 and amyloid-beta, in vitro, C6 rat glial cells were exposed to MPA for 48 h and then the enzymatic, secretory, and amyloid-beta degrading capacity of MMP-9 was assessed from the conditioned culture medium. We found that MPA treatment inhibited transcription of MMP-9, which resulted in a subsequent decrease in the production and secretion of MMP-9 protein, in part through the glucocorticoid receptor. …”

Image_2_Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner.TIF by Keyana N. Porter (8679852)

“…To assess the effect of progestins on MMP-9 and amyloid-beta, in vitro, C6 rat glial cells were exposed to MPA for 48 h and then the enzymatic, secretory, and amyloid-beta degrading capacity of MMP-9 was assessed from the conditioned culture medium. We found that MPA treatment inhibited transcription of MMP-9, which resulted in a subsequent decrease in the production and secretion of MMP-9 protein, in part through the glucocorticoid receptor. …”

Image_4_Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner.TIF by Keyana N. Porter (8679852)

“…To assess the effect of progestins on MMP-9 and amyloid-beta, in vitro, C6 rat glial cells were exposed to MPA for 48 h and then the enzymatic, secretory, and amyloid-beta degrading capacity of MMP-9 was assessed from the conditioned culture medium. We found that MPA treatment inhibited transcription of MMP-9, which resulted in a subsequent decrease in the production and secretion of MMP-9 protein, in part through the glucocorticoid receptor. …”

Image_5_Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner.TIF by Keyana N. Porter (8679852)

“…To assess the effect of progestins on MMP-9 and amyloid-beta, in vitro, C6 rat glial cells were exposed to MPA for 48 h and then the enzymatic, secretory, and amyloid-beta degrading capacity of MMP-9 was assessed from the conditioned culture medium. We found that MPA treatment inhibited transcription of MMP-9, which resulted in a subsequent decrease in the production and secretion of MMP-9 protein, in part through the glucocorticoid receptor. …”