<i>Escherichia coli</i> Cyclopropane Fatty Acid Synthase:  Is a Bound Bicarbonate Ion the Active-Site Base?^† by Fabienne Courtois (2667262)

“…However, because the E239Q mutation could not be rescued, we propose that E239 forms a catalytic dyad with the bicarbonate to perform the proton abstraction necessary in the chemical pathway to the cyclopropane ring.…”

<i>Escherichia coli</i> Cyclopropane Fatty Acid Synthase:  Is a Bound Bicarbonate Ion the Active-Site Base?^† by Fabienne Courtois (2667262)

“…However, because the E239Q mutation could not be rescued, we propose that E239 forms a catalytic dyad with the bicarbonate to perform the proton abstraction necessary in the chemical pathway to the cyclopropane ring.…”

A Dissolved Oxygen Threshold for Shifts in Bacterial Community Structure in a Seasonally Hypoxic Estuary by Rachel L. Spietz (782905)

“…To assess the effects of decreasing dissolved oxygen on bacteria, we examined shifts in bacterial community structure over space and time in Hood Canal, Washington, USA−a glacial fjord-like water body that experiences seasonal low dissolved oxygen levels known to be detrimental to fish and other marine organisms. …”

Caregivers’ transcripts. by Maggie Nyirenda-Nyang’wa (14129602)

Subjects:

Codebook. by Maggie Nyirenda-Nyang’wa (14129602)

Subjects:

Health workers and caregivers’ transcripts. by Maggie Nyirenda-Nyang’wa (14129602)

Subjects:

Data_Sheet_1_Introducing and Implementing HIV Self-Testing in Côte d'Ivoire, Mali, and Senegal: What Can We Learn From ATLAS Project Activity Reports in the Context of the COVID-19... by Arsène Kouassi Kra (11156478)

“…</p><p>Results: In all three countries, the pre-COVID-19 period was marked by a gradual increase in HIVST distribution. The period corresponding to the initial emergency response (March-May 2020) witnessed an important disruption of activities: a total suspension in Senegal, a significant decline in Côte d'Ivoire, and a less pronounced decrease in Mali. …”

Influence of External Force on Properties and Reactivity of Disulfide Bonds by Maria Francesca Iozzi (2219464)

“…Upon stretching, we make the following observations: the diradical character of the disulfide bridge increases; the energy difference between the singlet ground state and low-lying triplet state decreases; and the disulfide reduction is promoted by an external force in the range 0.1−0.4 nN. …”

Data_Sheet_2_A DNA Vaccine Encoding the Gn Ectodomain of Rift Valley Fever Virus Protects Mice via a Humoral Response Decreased by DEC205 Targeting.docx by Tiphany Chrun (6632588)

“…We recently showed that a DNA vaccine encoding eGn, the ectodomain of the RVFV Gn glycoprotein, conferred a substantial protection in the sheep natural host and that the anti-eGn IgG levels correlated to protection. …”

Data_Sheet_3_A DNA Vaccine Encoding the Gn Ectodomain of Rift Valley Fever Virus Protects Mice via a Humoral Response Decreased by DEC205 Targeting.docx by Tiphany Chrun (6632588)

“…We recently showed that a DNA vaccine encoding eGn, the ectodomain of the RVFV Gn glycoprotein, conferred a substantial protection in the sheep natural host and that the anti-eGn IgG levels correlated to protection. …”

Data_Sheet_1_A DNA Vaccine Encoding the Gn Ectodomain of Rift Valley Fever Virus Protects Mice via a Humoral Response Decreased by DEC205 Targeting.docx by Tiphany Chrun (6632588)

“…We recently showed that a DNA vaccine encoding eGn, the ectodomain of the RVFV Gn glycoprotein, conferred a substantial protection in the sheep natural host and that the anti-eGn IgG levels correlated to protection. …”

Moving Pieces in a Cellular Puzzle: A Cryptic Peptide from the Scorpion Toxin Ts14 Activates AKT and ERK Signaling and Decreases Cardiac Myocyte Contractility via Dephosphorylation... by Diana P. Goméz-Mendoza (9104908)

Moving Pieces in a Cellular Puzzle: A Cryptic Peptide from the Scorpion Toxin Ts14 Activates AKT and ERK Signaling and Decreases Cardiac Myocyte Contractility via Dephosphorylation... by Diana P. Goméz-Mendoza (9104908)

Deletion of murine <i>Rhoh</i> leads to de-repression of <i>Bcl-6</i> via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma by Hiroto Horiguchi (3215001)

“…The loss of Rhoh in Bcl-6^Tg mice led to a more rapid disease progression. Mechanistically, we demonstrated that deletion of Rhoh in these murine lymphoma cells was associated with decreased levels of the RhoH binding partner KAISO, a dual-specific Zinc finger transcription factor, de-repression of KAISO target Bcl-6, and downregulation of the BCL-6 target Blimp-1. …”

Supplementary Material for: Larger degree of renal function decline in CKD is a favorable factor for the attenuation of eGFR slope worsening by SGLT2 inhibitors: a retrospective ob... by Miyaoka Y. (18280342)

A scheme of the proposed model and of its encoding/decoding of the visual information. by Guido Maiello (811194)

Scrub typhus point-of-care testing: A systematic review and meta-analysis by Kartika Saraswati (5007164)

“…Overall, the commercially available scrub typhus ICTs demonstrated better performance when ‘ruling in’ the diagnosis. There is a need for standardised methods and reporting of diagnostic accuracy to decrease between-study heterogeneity and increase comparability among study results, as well as development of an affordable and accurate antigen-based POCT to tackle the inherent weaknesses associated with serological testing.…”

Influence of Thiolate Ligands on Reductive N−O Bond Activation. Probing the O₂⁻ Binding Site of a Biomimetic Superoxide Reductase Analogue and Examining the P... by Gloria Villar-Acevedo (2232583)

“…Like NO-bound <i>trans</i>-cysteinate-ligated SOR (SOR-NO), the rhombic <i>S</i> = 3/2 EPR signal of NO-bound <i>cis</i>-thiolate-ligated [Fe(S^Me₂N₄(tren)(NO)]⁺ (<b>2</b>; <i>g</i> = 4.44, 3.54, 1.97), the isotopically sensitive ν_NO(ν_¹⁵NO) stretching frequency (1685(1640) cm⁻¹), and the 0.05 Å decrease in Fe−S bond length are shown to be consistent with <i>the oxidative addition of NO to Fe(II)</i> to afford an Fe(III)−NO⁻ {FeNO}⁷ species containing high-spin (<i>S</i> = 5/2) Fe(III) antiferromagnetically coupled to NO⁻ (<i>S</i> = 1). …”

Influence of Thiolate Ligands on Reductive N−O Bond Activation. Probing the O₂⁻ Binding Site of a Biomimetic Superoxide Reductase Analogue and Examining the P... by Gloria Villar-Acevedo (2232583)

“…Like NO-bound <i>trans</i>-cysteinate-ligated SOR (SOR-NO), the rhombic <i>S</i> = 3/2 EPR signal of NO-bound <i>cis</i>-thiolate-ligated [Fe(S^Me₂N₄(tren)(NO)]⁺ (<b>2</b>; <i>g</i> = 4.44, 3.54, 1.97), the isotopically sensitive ν_NO(ν_¹⁵NO) stretching frequency (1685(1640) cm⁻¹), and the 0.05 Å decrease in Fe−S bond length are shown to be consistent with <i>the oxidative addition of NO to Fe(II)</i> to afford an Fe(III)−NO⁻ {FeNO}⁷ species containing high-spin (<i>S</i> = 5/2) Fe(III) antiferromagnetically coupled to NO⁻ (<i>S</i> = 1). …”

The 20 most common procedures. by Sixten Melander (22521804)

“…The most dramatic decrease was found in county hospitals where elective surgery was reduced by 28% and the largest effect was found in Ear, Nose, and Throat/oral surgery (−34%). …”