Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Medical food cocktail diet reduces Aβ levels and decreases aggregation. by Anna Parachikova (359716)

Data and code from: Continental declines in North American small mammal populations by Alec Medd (20968740)

“…We then used a hierarchical Bayesian modelling approach to estimate an overall abundance trend. …”

<i>In vivo</i> recordings from juvenile MSO neurons. by Martijn C. Sierksma (11608174)

Catalyst Cluster-Induced Support Restructuring by Salman A. Khan (12450482)

“…Unlike the belief that the metal dispersion decreases with an increase in size, we show that intermediate-sized clusters have the largest fraction of exposed surface atoms. …”

Serum concentrations of the Analytes, Cytokines (A)TNF-α, (B) IL-1β, (C) IL-10, (D) IL-6 and (E) nitric oxide derivatives (NOx) (Whiskers extend from the smallest value to the larg... by Sakuni Rankothgedera (11457923)

Scaling exponent α for the whole measuring period 1980–2000 as a function of publication year; numbers are the averages of successive five-years blocks, each five-years block is lo... by Anthony F. J. van Raan (7517696)

The effects of pretreatment with fingolimod-phosphate on NFκB in the presence of MS sera. by Hideaki Nishihara (545149)

Trust levels before and after the COVID-19 pandemic (n = 10,000). by Alain Abi-Rizk (8549358)

Distribution of individual change in trust in science before and after the pandemic (n = 10,000). by Alain Abi-Rizk (8549358)

Relationship between monthly NDVI and climatic variables values (Tmax, maximum air temperature; P, precipitation; VPD, vapor pressure deficit), in areas with decreasing trends (<i>... by Oswaldo Maillard (20660661)

Unexpected Parabolic Temperature Dependency of CH₄ Emissions from Rice Paddies by Haoyu Qian (800177)

“…Global warming is expected to affect methane (CH₄) emissions from rice paddies, one of the largest human-induced sources of this potent greenhouse gas. …”

Viscous, acoustic, and thermal contributions to the normalized damping factor <i>β</i>′. by Mark W. Sprague (12220544)

Unadjusted mean (SD) volume (ml) of beer sold per day, overall and by serving size, and volume of wine (ml) sold of premises included in primary analysis (<i>n</i> = 12). by Eleni Mantzari (6991172)

Subjects:

Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress by Scott M. Thompson (231230)

“…Finally, we showed that AKT isoforms 1, 2 and 3 are differentially upregulated in primary human HCCs and that overexpression of AKT correlates with worse tumor biology and pathologic features (AKT3) and prognosis (AKT1). …”

Section A represents a randomised trial of IL6RA therapy with both normal IL-6 signalling and the effect of intervention. by Fergus W. Hamilton (10724401)

Sex differences in baseline characteristics. by Kirsten Grossmann (10704657)

“…<div><p>Considering sex as a biological variable in modern digital health solutions, we investigated sex-specific differences in the trajectory of four physiological parameters across a COVID-19 infection. …”

Frequency of accessions according to resistant and susceptible classes to orange rust and also according to the presence and absence of the molecular marker <i>G1</i>. by Gleicy Kelly Oliveira (19259604)

Subjects: