Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Thus, its implication in cancer progression makes it an attractive target in anticancer therapy. Herein, we describe the design, synthesis, and biological evaluation of new benzazoles as heparanase inhibitors. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Thus, its implication in cancer progression makes it an attractive target in anticancer therapy. Herein, we describe the design, synthesis, and biological evaluation of new benzazoles as heparanase inhibitors. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Thus, its implication in cancer progression makes it an attractive target in anticancer therapy. Herein, we describe the design, synthesis, and biological evaluation of new benzazoles as heparanase inhibitors. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Thus, its implication in cancer progression makes it an attractive target in anticancer therapy. Herein, we describe the design, synthesis, and biological evaluation of new benzazoles as heparanase inhibitors. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Thus, its implication in cancer progression makes it an attractive target in anticancer therapy. Herein, we describe the design, synthesis, and biological evaluation of new benzazoles as heparanase inhibitors. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Thus, its implication in cancer progression makes it an attractive target in anticancer therapy. Herein, we describe the design, synthesis, and biological evaluation of new benzazoles as heparanase inhibitors. …”

Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development by Christopher R. Schlieve (3179439)

“…<div><p>Background</p><p>Vascular endothelial growth factor (VEGF) is a highly conserved, master regulatory molecule required for endothelial cell proliferation, organization, migration and branching morphogenesis. …”

Influence of heterogeneities in transmission. by Kris V. Parag (4540165)

“…<p>We investigate how differences in transmissibility among groups (e.g., due to demographic or spatial factors) fundamentally limit the ability to detect resurgence from a specific group (in this example group 1 with reproduction number <i>R</i>_<i>s</i>[1]). …”

When there are no group events, mutations cause community extinction, but group-level events prevent this fate, as exemplified by the three archetypal modes of fragmentation. by Gil J. B. Henriques (11426697)

“…<p>The figures show the time-dynamics of populations (initiated with 100 groups, each containing 100 cooperator cells). <b>A</b>: Example replicate with no group events (i.e., no group fission and extinction), showing fast initial rise in the number of mutants and the consequential decrease in the total cell number, resulting in extinction. …”

Image_1_IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.TIF by Hilde L. Orrem (5740313)

“…</p><p>Results: Our main findings were (i) Tocilizumab decreased C5aR1 and C5aR2 mRNA expression significantly (p < 0.001) and substantially (>50%) at day 2 and 3, whereas C3aR expression was unaffected. …”

Image_2_IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.TIF by Hilde L. Orrem (5740313)

“…</p><p>Results: Our main findings were (i) Tocilizumab decreased C5aR1 and C5aR2 mRNA expression significantly (p < 0.001) and substantially (>50%) at day 2 and 3, whereas C3aR expression was unaffected. …”

Table_1_IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.DOCX by Hilde L. Orrem (5740313)

“…</p><p>Results: Our main findings were (i) Tocilizumab decreased C5aR1 and C5aR2 mRNA expression significantly (p < 0.001) and substantially (>50%) at day 2 and 3, whereas C3aR expression was unaffected. …”

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of Ca_V2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca²⁺ In... by Maria Isabel Bahamonde (840859)

“…Functional studies of ΔF1502 Ca_V2.1 channels, expressed in <i>Xenopus</i> oocytes, using the non-physiological Ba²⁺ as the charge carrier have only revealed discrete alterations in channel function of unclear pathophysiological relevance. Here, we report a second case of congenital ataxia linked to the ΔF1502 α_1A mutation, detected by whole-exome sequencing, and analyze its functional consequences on Ca_V2.1 human channels heterologously expressed in mammalian tsA-201 HEK cells, using the physiological permeant ion Ca²⁺. …”

Clinical experience with the inactivated hepatitis A vaccine, Avaxim 80U Pediatric by Catherine Bravo (5822357)

“…Prevalence of hepatitis A is strongly correlated with socioeconomic factors, decreasing with increased socio-economic development, access to clean water and sanitation. …”

Stem plot of PC 1 scores (vertical axis), representing all three phases within participants Hold (red); Aim (yellow); Execute (green). by Brienna Eteson (21416834)

Salt-tolerant and -sensitive alfalfa (<i>Medicago sativa</i>) cultivars have large variations in defense responses to the lepidopteran insect <i>Spodoptera litura</i> under normal... by Yunting Lei (4256269)

“…We propose a mechanism, in which high levels of abscisic acid induced by salt treatment may affect the expression levels of <i>JAR1</i> and consequently decrease JA-Ile accumulation and thus partly suppress the defense of Xinjiang Daye against insects under salt stress. …”

Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP–SETDB1 Complex for Enhancing Difficult-to-Express Protein Production by Su Hyun Kim (828853)

Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP–SETDB1 Complex for Enhancing Difficult-to-Express Protein Production by Su Hyun Kim (828853)

Data Sheet 1_Unlocking the adaptation mechanisms of the oleaginous microalga Scenedesmus sp. BHU1 under elevated salt stress: a physiochemical, lipidomics and transcriptomics appro... by Rahul Prasad Singh (20283954)

“…<p>Microalgae are vital for their photosynthetic abilities, contributing significantly to global oxygen production, serving as a key trophic level in aquatic ecosystems, aiding in biofuel production, assisting in wastewater treatment, and facilitating the synthesis of valuable biochemicals. …”

Data_Sheet_1_Copper Tolerance Mediated by FgAceA and FgCrpA in Fusarium graminearum.docx by Xin Liu (43569)

“…△FgCrpA and △FgAceA were reduced in virulence in flowering wheat heads and synthesized decreased amounts of the mycotoxin deoxynivalenol when challenged with excess Cu. …”