Phosphoproteomics Profiling Reveals Key Proteins Involved in Neuroinflammation and Impaired Axon Guidance Induced by Bilirubin Deficiency by Ming Chen (115604)

“…Hypobilirubinemia, characterized by low bilirubin levels, is increasingly recognized as a pathological condition linked to various neurodevelopmental and neurodegenerative diseases. …”

Image1_Effects of winter pulsed warming and snowmelt on soil nitrogen cycling in agricultural soils: A lysimeter study.JPEG by Danielle Green (522450)

“…We monitored the subsurface soil temperature, moisture, and porewater geochemistry together with air temperature, precipitation, and N₂O fluxes in four agricultural field-controlled lysimeter systems (surface area of 1 m² and depth of 1.5 m) at the University of Guelph’s Elora Research Station over one winter (December 2020 to April 2021). …”

The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria by Kshipra Singh (178874)

“…We assessed the role of SLC7A2 in murine infection with <i>Citrobacter rodentium</i>, an attaching and effacing enteric pathogen that causes colitis. …”

Whole Blood Gene Expression Differentiates between Atrial Fibrillation and Sinus Rhythm after Cardioversion by Kripa Raman (774920)

“…We validated the association between <i>SLC25A20</i> and <i>PDK4</i> with AF in an independent sample of 17 patients.…”

Unusual clinical phenotype of Stargardt disease by Pedro Molina-Solana (12683949)

“…(Ala.1038Val), in the ABCA4 gene. Based on our results, we believe that these particular mutations in the ABCA4 gene could be associated with a specific disease phenotype characterized by funduscopic appearance similar to pattern dystrophy. …”

Photochemical Properties of Re(CO)₃ Complexes with and without a Local Proton Source and Implications for CO₂ Reduction Catalysis by Lucas A. Paul (8990561)

“…Herein, we present a detailed study on the photophysical properties and the excited state reactivity of two mononuclear Re­(CO)₃ complexes with imdazol-pyridine ligands equipped with and without a local proton source, [Re­(CO)₃LCl], where for <b>1</b>: L = 2,4-di<i>tert</i>-butyl-6-(6-(1-methyl-1<i>H</i>-imidazol-2-yl)­pyridin-2-yl)­phenol and <b>2</b>: L = 2-(3,5-di<i>tert</i>-butyl-2-methoxyphenyl)-6-(1-methyl-1<i>H</i>-imidazol-2-yl)­pyridine. …”

DataSheet_1_Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation.doc... by Andreea C. Mihaila (11252988)

“…We aimed to investigate the phenotypic and functional differences between N1 and N2 neutrophils, and to identify the potential contribution of the S100A9 alarmin in neutrophil polarization. …”

Table_1_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.DOCX by Ebru Karasu (5158097)

“…In a mono-centered prospective clinical study with polytraumatized patients, we found significantly increased granulocyte-derived MVs containing the C5a receptor (C5aR1, CD88) on their surface. …”

Image_1_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…In a mono-centered prospective clinical study with polytraumatized patients, we found significantly increased granulocyte-derived MVs containing the C5a receptor (C5aR1, CD88) on their surface. …”

Image_4_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…In a mono-centered prospective clinical study with polytraumatized patients, we found significantly increased granulocyte-derived MVs containing the C5a receptor (C5aR1, CD88) on their surface. …”

Image_2_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…In a mono-centered prospective clinical study with polytraumatized patients, we found significantly increased granulocyte-derived MVs containing the C5a receptor (C5aR1, CD88) on their surface. …”

Image_3_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…In a mono-centered prospective clinical study with polytraumatized patients, we found significantly increased granulocyte-derived MVs containing the C5a receptor (C5aR1, CD88) on their surface. …”

The Recovery of Plastid Function Is Required for Optimal Response to Low Temperatures in <i>Arabidopsis</i> by Peter Kindgren (795049)

“…The <i>gun5-1</i> and <i>cch</i> alleles showed an inability to recover chlorophyll biosynthesis in addition to a significant decrease in freezing tolerance. We found that the impaired plastid function in the CHLH mutant plants resulted in compromised <i>de novo</i> protein synthesis at low temperatures. …”

Data_Sheet_1_The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis.PDF by Kelly F. Paton (3934061)

“…In the experimental autoimmune encephalomyelitis model, we found that EOM SalB (0.1–0.3 mg/kg) effectively decreased disease severity in a KOR-dependent manner and led to a greater number of animals in recovery compared to U50,488 treatment. …”

Jmjd6a regulates <i>GSK3β</i> RNA splicing in <i>Xenopus laevis</i> eye development by Jee Yoon Shin (7067369)

“…We further found down-regulation of gene expression related to eye development such as <i>Rx1</i>, <i>Otx2</i>, and <i>Pax6</i> in <i>Jmjd6a</i> morpholino injected embryos. …”

Data_Sheet_1_C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection.DOCX by Daria Briukhovetska (9098294)

“…Further, C3 can bind to T. gondii resulting in limited complement activation. Here, we determined the role of C5a/C5aR1 axis activation for the early innate immune response in a mouse model of peritoneal T. gondii infection. …”

Table_1_Efficacy and safety of hypoglycemic drugs in improving cognitive function in patients with Alzheimer's disease and mild cognitive impairment: A systematic review and networ... by Xin-Chen Wang (14193917)

“…We performed a network meta-analysis, which we report here according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). …”

Supplementary Material for: The Endothelin-1 Pathway and the Development of Cardiovascular Defects in the Haemodynamically Challenged Chicken Embryo by Groenendijk B.C.W. (4106389)

“…These abnormalities are similar to malformations observed in knockout mice studies of components of the endothelin-1 (ET-1)/endothelin-converting enzyme-1/endothelin-A receptor pathway. In previous studies we demonstrated that cardiac <i>ET-1</i> expression is decreased 3 h after clipping, and ventricular diastolic filling is disturbed after 2 days. …”

The Role of <i>HOXB9</i> and <i>miR-196a</i> in Head and Neck Squamous Cell Carcinoma by Lav Darda (720370)

“…We identified a novel primary mRNA transcript containing <i>HOXB9</i> and <i>miR196a-1</i> as predicted from <i>in-silico</i> analysis. …”

Image 1_EPHA2 promotes triple-negative breast cancer progression by suppressing pyroptosis via the AKT/PI3K/mTOR pathway.tif by Xiaoying Huang (328697)

“…Additionally, we observed a decreased expression of ferroptosis-associated marker named SLC7A11, suggesting that this transporter may mediate the effects of AKT inhibition on pyroptosis.…”