Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum by Francianne M. Amorim (3133902)

“…<div><p>Background</p><p>Leprosy is a treatable infectious disease caused by <i>Mycobacterium leprae</i>. …”

Segregation in Drying Binary Colloidal Droplets by Wendong Liu (507488)

“…While drying, the droplets maintain a nearly perfect spherical shape. Here, we exploit this phenomenon to fabricate supraparticles from bidisperse colloidal aqueous suspensions. …”

Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria by Shimon Bershtein (816147)

“…Here we performed inter-species replacement of the chromosomal <i>folA</i> gene, encoding an essential metabolic enzyme dihydrofolate reductase (DHFR), with orthologs from 35 other mesophilic bacteria. …”

Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth by Xing Feng (715316)

“…Importantly, we provide <i>in vitro</i> and <i>in vivo</i> evidence that UVRAG ubiquitination at lysine residues 517 and 559 or prevention of Ser522 phosphorylation by D4476, a CSNK1A1 inhibitor, enhances the lysosomal degradation of EGFR, which significantly inhibits hepatocellular carcinoma (HCC) growth. …”

DataSheet1_Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study.pdf by Mingming Pan (5576021)

“…We aimed to evaluate its safety, pharmacokinetics and efficacy in hemodialysis patients over a 1-week treatment period, and to establish the optimal dosage for a further 12-week stage 2 trial.…”

The effect of instilling the ophthalmic solution on the LF/HF ratio and typical cases of fluctuations in the LF/HF ratio over time in the DE and non-DE groups. by Minako Kaido (309626)

“…The non-DE case is of a 21-year-old woman with a J-OSDI score of 9.1 points. The fluctuation in the LF/HF ratio of the DE case is larger than of the non-DE case, and it decreases post-instillation. …”

Trends in polypharmacy over 12 years and changes in its social gradients in South Korea by Yeon-Hee Baek (5759345)

“…We repeated logistic regressions for pediatrics <20 years of age and adults ≥20 years of age to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI). …”

Data_Sheet_1_Elevated first-trimester hepcidin level is associated with reduced risk of iron deficiency anemia in late pregnancy: a prospective cohort study.PDF by Peng Sun (112156)

“…</p>Results<p>Serum hepcidin levels substantially decreased from 19.39 ng/mL in the first trimester to 1.32 ng/mL in the third trimester. …”

Ubr3 regulates the ubiquitination of Cos2. by Tongchao Li (115391)

“…Over-expression of Ubr3 increases ubiquitinated Cos2 (lane 2), whereas down-regulation of Ubr3 through Ubr3 RNAi (lane 3) decreases ubiquitinated Cos2. GFP^RNAi was used as a negative control. …”

Shell-Protective Secondary Silicon Nanostructures as Pressure-Resistant High-Volumetric-Capacity Anodes for Lithium-Ion Batteries by Jiangyan Wang (459195)

“…However, challenges with weak mechanical stability during the calendering process of electrode fabrication and poor volumetric energy density remain to be solved. Here we fabricated a pressure-resistant silicon structure by designing a dense silicon shell coating on secondary micrometer particles, each consisting of many silicon nanoparticles. …”

Shell-Protective Secondary Silicon Nanostructures as Pressure-Resistant High-Volumetric-Capacity Anodes for Lithium-Ion Batteries by Jiangyan Wang (459195)

“…However, challenges with weak mechanical stability during the calendering process of electrode fabrication and poor volumetric energy density remain to be solved. Here we fabricated a pressure-resistant silicon structure by designing a dense silicon shell coating on secondary micrometer particles, each consisting of many silicon nanoparticles. …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…The treatment of inflammatory bowel disease (IBD) may rely on the comprehensive regulation of immune inflammatory factors to reach a favorable therapeutic effect. In the current study, we discovered a series of sEH inhibitors containing a squaryl sulfonamide scaffold that potently inhibited the primary proinflammatory signaling pathways of NF-κB. …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…The treatment of inflammatory bowel disease (IBD) may rely on the comprehensive regulation of immune inflammatory factors to reach a favorable therapeutic effect. In the current study, we discovered a series of sEH inhibitors containing a squaryl sulfonamide scaffold that potently inhibited the primary proinflammatory signaling pathways of NF-κB. …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…The treatment of inflammatory bowel disease (IBD) may rely on the comprehensive regulation of immune inflammatory factors to reach a favorable therapeutic effect. In the current study, we discovered a series of sEH inhibitors containing a squaryl sulfonamide scaffold that potently inhibited the primary proinflammatory signaling pathways of NF-κB. …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…The treatment of inflammatory bowel disease (IBD) may rely on the comprehensive regulation of immune inflammatory factors to reach a favorable therapeutic effect. In the current study, we discovered a series of sEH inhibitors containing a squaryl sulfonamide scaffold that potently inhibited the primary proinflammatory signaling pathways of NF-κB. …”

TET1 regulates the mRNA and protein expression of TNFα. by Fangfang Sun (2410654)

Intraspecific variability in <i>Phaeocystis antarctica's</i> response to iron and light stress by Katja E. Luxem (1332405)

“…Physiologically, only three of the four clones shrink or decrease the concentration of chlorophyll <i>a</i> in response to iron limitation, and only one clone decreases colony formation. …”

Effects of MDMA Injections on the Behavior of Socially-Housed Long-Tailed Macaques (<i>Macaca fascicularis</i>) by Sébastien Ballesta (680571)

“…However, this effect has never been assessed on the social behavior of non-human primates. In our study, we subcutaneously injected three different doses of MDMA (1.0, 1.5 or 2.0mg/kg) to a group of three, socially housed, young male long-tailed macaques. …”

The Prognostic Role of <i>BRAF</i> Mutation in Metastatic Colorectal Cancer Receiving Anti-<i>EGFR</i> Monoclonal Antibodies: A Meta-Analysis by Zi-Xu Yuan (420280)

“…In KRAS WT population, there were even larger PFS benefit (HR 0.29[0.19,0.43]) and larger OS benefit (HR 0.26 [0.20,0.35]) in BRAF WT. …”

High Light Yield of Sr₈(Si₄O₁₂)Cl₈:Eu²⁺ under X‑ray Excitation and Its Temperature-Dependent Luminescence Characteristics by Chunmeng Liu (1435927)

“…It is found that with increases in temperature, lattice expansion takes place without significant distortion of the coordination around Eu²⁺. As a result, the crystal field splitting of the Eu²⁺ 5d state decreases. …”