Image_4_Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage.jpeg by Javier Chicote (9521855)

“…Among them, 3-methyladenine, SBI-0206965, Chloroquine, and Bafilomycin A₁ triggered BAX- and/or BAK-dependent cytotoxicity and caspase activation. 3-methyladenine was the only compound to induce a consistent and abrupt decrease in cell viability across a series of ontologically unrelated human cell lines. 3-methyladenine-induced cytotoxicity was not driven by the inhibition of the AKT/mTOR axis. …”

Image_2_Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage.jpeg by Javier Chicote (9521855)

“…Among them, 3-methyladenine, SBI-0206965, Chloroquine, and Bafilomycin A₁ triggered BAX- and/or BAK-dependent cytotoxicity and caspase activation. 3-methyladenine was the only compound to induce a consistent and abrupt decrease in cell viability across a series of ontologically unrelated human cell lines. 3-methyladenine-induced cytotoxicity was not driven by the inhibition of the AKT/mTOR axis. …”

Image_1_Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage.jpeg by Javier Chicote (9521855)

“…Among them, 3-methyladenine, SBI-0206965, Chloroquine, and Bafilomycin A₁ triggered BAX- and/or BAK-dependent cytotoxicity and caspase activation. 3-methyladenine was the only compound to induce a consistent and abrupt decrease in cell viability across a series of ontologically unrelated human cell lines. 3-methyladenine-induced cytotoxicity was not driven by the inhibition of the AKT/mTOR axis. …”

Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension by Csaba Galambos (3143886)

“…</p><p>Conclusions</p><p>We conclude that lung anti-angiogenic factors, including <i>COL18A1</i> (ES), <i>COL4A3</i>, <i>TIMP3</i> and <i>APP</i> are over-expressed and fetal lung vessel growth is decreased in subjects with DS. …”

The Prognostic Role of <i>BRAF</i> Mutation in Metastatic Colorectal Cancer Receiving Anti-<i>EGFR</i> Monoclonal Antibodies: A Meta-Analysis by Zi-Xu Yuan (420280)

“…In KRAS WT population, there were even larger PFS benefit (HR 0.29[0.19,0.43]) and larger OS benefit (HR 0.26 [0.20,0.35]) in BRAF WT. …”

Table 1_Global, regional, and national burden of atrial fibrillation/flutter attributable to metabolic, behavioral, and environmental risk factors, 1990–2021: a longitudinal observ... by Zhen Wei (203204)

“…</p>Results<p>Over the past 32 years, high body mass index has been the primary contributor to the rising AF/AFL burden, with AAPCs of ASMR and ASDR at 1.66 (95% CI: 1.63–1.68) and 1.68 (95% CI: 1.67–1.70), respectively. …”

Data_Sheet_1_Elevated first-trimester hepcidin level is associated with reduced risk of iron deficiency anemia in late pregnancy: a prospective cohort study.PDF by Peng Sun (112156)

“…</p>Results<p>Serum hepcidin levels substantially decreased from 19.39 ng/mL in the first trimester to 1.32 ng/mL in the third trimester. …”

Mass Spectrometric Analysis of Urine from COVID-19 Patients for Detection of SARS-CoV‑2 Viral Antigen and to Study Host Response by Sandip Chavan (1590289)

“…Although microbial identification in clinical microbiology using mass spectrometry is undertaken after culture, here we undertook a mass spectrometry-based approach that employed an enrichment step to capture and detect SARS-CoV-2 nucleocapsid protein directly from urine of COVID-19 patients without any culture. …”

Mass Spectrometric Analysis of Urine from COVID-19 Patients for Detection of SARS-CoV‑2 Viral Antigen and to Study Host Response by Sandip Chavan (1590289)

“…Although microbial identification in clinical microbiology using mass spectrometry is undertaken after culture, here we undertook a mass spectrometry-based approach that employed an enrichment step to capture and detect SARS-CoV-2 nucleocapsid protein directly from urine of COVID-19 patients without any culture. …”

Mass Spectrometric Analysis of Urine from COVID-19 Patients for Detection of SARS-CoV‑2 Viral Antigen and to Study Host Response by Sandip Chavan (1590289)

“…Although microbial identification in clinical microbiology using mass spectrometry is undertaken after culture, here we undertook a mass spectrometry-based approach that employed an enrichment step to capture and detect SARS-CoV-2 nucleocapsid protein directly from urine of COVID-19 patients without any culture. …”

Model for transcriptional control of aging. by Frederick G. Mann (263292)

The process of tracheal development in the <i>Drosophila</i> visual system. by Wei-Chen Chu (450265)

“…Bifurcating branches can be observed (white arrow). (I–J) The tracheal pattern at later pupal stages were labeled by <i>btl > DsRed</i> (white) in <i>GMR-wIR</i> in order to decrease the autofluorescence from the red pigments of eye. …”

Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria by Shimon Bershtein (816147)

“…Here we performed inter-species replacement of the chromosomal <i>folA</i> gene, encoding an essential metabolic enzyme dihydrofolate reductase (DHFR), with orthologs from 35 other mesophilic bacteria. …”

Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum by Francianne M. Amorim (3133902)

“…<div><p>Background</p><p>Leprosy is a treatable infectious disease caused by <i>Mycobacterium leprae</i>. …”

Segregation in Drying Binary Colloidal Droplets by Wendong Liu (507488)

“…While drying, the droplets maintain a nearly perfect spherical shape. Here, we exploit this phenomenon to fabricate supraparticles from bidisperse colloidal aqueous suspensions. …”

Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth by Xing Feng (715316)

“…Importantly, we provide <i>in vitro</i> and <i>in vivo</i> evidence that UVRAG ubiquitination at lysine residues 517 and 559 or prevention of Ser522 phosphorylation by D4476, a CSNK1A1 inhibitor, enhances the lysosomal degradation of EGFR, which significantly inhibits hepatocellular carcinoma (HCC) growth. …”

DataSheet1_Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study.pdf by Mingming Pan (5576021)

“…We aimed to evaluate its safety, pharmacokinetics and efficacy in hemodialysis patients over a 1-week treatment period, and to establish the optimal dosage for a further 12-week stage 2 trial.…”

Trends in polypharmacy over 12 years and changes in its social gradients in South Korea by Yeon-Hee Baek (5759345)

“…We repeated logistic regressions for pediatrics <20 years of age and adults ≥20 years of age to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI). …”

Ubr3 regulates the ubiquitination of Cos2. by Tongchao Li (115391)

“…Over-expression of Ubr3 increases ubiquitinated Cos2 (lane 2), whereas down-regulation of Ubr3 through Ubr3 RNAi (lane 3) decreases ubiquitinated Cos2. GFP^RNAi was used as a negative control. …”

The effect of instilling the ophthalmic solution on the LF/HF ratio and typical cases of fluctuations in the LF/HF ratio over time in the DE and non-DE groups. by Minako Kaido (309626)

“…The non-DE case is of a 21-year-old woman with a J-OSDI score of 9.1 points. The fluctuation in the LF/HF ratio of the DE case is larger than of the non-DE case, and it decreases post-instillation. …”