Data_Sheet_1_Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.xlsx by Mylarappa Ningappa (797089)

“…The effects of heterozygous mutation, and the potential for rescue are not known.</p>Purpose<p>We hypothesized that survival and lung ciliation, (a) would decrease progressively in Man1a2^+/− heterozygous and Man1a2^–/– null newborn pups compared with WT, and (b) could be enhanced by gestational treatment with N-Acetyl-cysteine (NAC), an antioxidant.…”

Image_1_Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.TIF by Mylarappa Ningappa (797089)

“…The effects of heterozygous mutation, and the potential for rescue are not known.</p>Purpose<p>We hypothesized that survival and lung ciliation, (a) would decrease progressively in Man1a2^+/− heterozygous and Man1a2^–/– null newborn pups compared with WT, and (b) could be enhanced by gestational treatment with N-Acetyl-cysteine (NAC), an antioxidant.…”

Image_3_Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.TIF by Mylarappa Ningappa (797089)

“…The effects of heterozygous mutation, and the potential for rescue are not known.</p>Purpose<p>We hypothesized that survival and lung ciliation, (a) would decrease progressively in Man1a2^+/− heterozygous and Man1a2^–/– null newborn pups compared with WT, and (b) could be enhanced by gestational treatment with N-Acetyl-cysteine (NAC), an antioxidant.…”

Image_2_Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.TIF by Mylarappa Ningappa (797089)

“…The effects of heterozygous mutation, and the potential for rescue are not known.</p>Purpose<p>We hypothesized that survival and lung ciliation, (a) would decrease progressively in Man1a2^+/− heterozygous and Man1a2^–/– null newborn pups compared with WT, and (b) could be enhanced by gestational treatment with N-Acetyl-cysteine (NAC), an antioxidant.…”

Image_6_Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.TIF by Mylarappa Ningappa (797089)

“…The effects of heterozygous mutation, and the potential for rescue are not known.</p>Purpose<p>We hypothesized that survival and lung ciliation, (a) would decrease progressively in Man1a2^+/− heterozygous and Man1a2^–/– null newborn pups compared with WT, and (b) could be enhanced by gestational treatment with N-Acetyl-cysteine (NAC), an antioxidant.…”

Image_3_Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.TIF by Mylarappa Ningappa (797089)

“…The effects of heterozygous mutation, and the potential for rescue are not known.</p>Purpose<p>We hypothesized that survival and lung ciliation, (a) would decrease progressively in Man1a2^+/− heterozygous and Man1a2^–/– null newborn pups compared with WT, and (b) could be enhanced by gestational treatment with N-Acetyl-cysteine (NAC), an antioxidant.…”

Cell Cycle- and Cancer-Associated Gene Networks Activated by Dsg2: Evidence of Cystatin A Deregulation and a Potential Role in Cell-Cell Adhesion by Abhilasha Gupta (532794)

“…Following microarray and gene network analysis, we demonstrate that Dsg2 caused a profound change in the transcriptome of keratinocytes <i>in vivo</i> and altered a number of genes important in epithelial dysplasia including: calcium-binding proteins (S100A8 and S100A9), members of the cyclin protein family, and the cysteine protease inhibitor cystatin A (CSTA). …”

Suspect and Nontarget Screening Reveal the Underestimated Risks of Antibiotic Transformation Products in Wastewater Treatment Plant Effluents by Jingrun Hu (17342142)

“…Herein, we developed a comprehensive suspect and nontarget screening workflow based on high-resolution mass spectrometry to identify unknown antibiotic TPs in wastewater treatment plant effluents. …”

Spatially and Chemically Resolved Visualization of Fe Incorporation into NiO Octahedra during the Oxygen Evolution Reaction by Fengli Yang (5373857)

“…Electrochemically, the NiFe-LDH formation correlates with a lower onset potential toward the OER, whereas the formation of the FeO_<i>x</i> aggregates is accompanied by a gradual decrease in the OER activity. …”

Combined Quantitative (Phospho)proteomics and Mass Spectrometry Imaging Reveal Temporal and Spatial Protein Changes in Human Intestinal Ischemia–Reperfusion by Anna M. Kip (11804493)

“…We identified a significant decrease in abundance of proteins related to intestinal absorption, microvillus, and cell junction, whereas proteins involved in innate immunity, in particular the complement cascade, and extracellular matrix organization increased in abundance after IR. …”

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…On day 15, <i>fbp-1(RNAi)</i> decreases swimming rates by 44%, and <i>pck-2(RNAi)</i> animals moved too slowly to measure (or were dead) (marked as N/A). …”

Data_Sheet_1_Identification of gene family members and a key structural variation reveal important roles of OVATE genes in regulating tea (Camellia sinensis) leaf development.PDF by Yanlin An (8089781)

“…In addition, we identified a key structural variation with a length of 184 bp, and the population genotyping showed that it was closely related to the area of tea leaves. …”

Image1_Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation.tif by Tongling Liufu (16830612)

“…The NAD⁺/NADH ratio was also significantly reduced in m.3243 A>G fibroblasts, and, using fluorescence lifetime imaging microscopy, we also found that the NADH level was elevated in m.3243 A>G fibroblasts. …”

Image1_Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop.tif by Xu Liu (276996)

“…In terms of mechanism, we found that HCG18 positively regulated the expression of BC-related ubiquitin-conjugating enzyme E2O (UBE2O) by sponging miR-103a-3p, and our previous research verified that UBE2O could promote the malignant phenotypes of BC cells through the UBE2O/AMPKα2/mTORC1 axis. …”

Table2_Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop.docx by Xu Liu (276996)

“…In terms of mechanism, we found that HCG18 positively regulated the expression of BC-related ubiquitin-conjugating enzyme E2O (UBE2O) by sponging miR-103a-3p, and our previous research verified that UBE2O could promote the malignant phenotypes of BC cells through the UBE2O/AMPKα2/mTORC1 axis. …”

Image2_Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop.JPEG by Xu Liu (276996)

“…In terms of mechanism, we found that HCG18 positively regulated the expression of BC-related ubiquitin-conjugating enzyme E2O (UBE2O) by sponging miR-103a-3p, and our previous research verified that UBE2O could promote the malignant phenotypes of BC cells through the UBE2O/AMPKα2/mTORC1 axis. …”

Table3_Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop.docx by Xu Liu (276996)

“…In terms of mechanism, we found that HCG18 positively regulated the expression of BC-related ubiquitin-conjugating enzyme E2O (UBE2O) by sponging miR-103a-3p, and our previous research verified that UBE2O could promote the malignant phenotypes of BC cells through the UBE2O/AMPKα2/mTORC1 axis. …”

Image3_Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation.tif by Tongling Liufu (16830612)

“…The NAD⁺/NADH ratio was also significantly reduced in m.3243 A>G fibroblasts, and, using fluorescence lifetime imaging microscopy, we also found that the NADH level was elevated in m.3243 A>G fibroblasts. …”

Image1_Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop.tif by Xu Liu (276996)

“…In terms of mechanism, we found that HCG18 positively regulated the expression of BC-related ubiquitin-conjugating enzyme E2O (UBE2O) by sponging miR-103a-3p, and our previous research verified that UBE2O could promote the malignant phenotypes of BC cells through the UBE2O/AMPKα2/mTORC1 axis. …”

Image2_Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation.tif by Tongling Liufu (16830612)

“…The NAD⁺/NADH ratio was also significantly reduced in m.3243 A>G fibroblasts, and, using fluorescence lifetime imaging microscopy, we also found that the NADH level was elevated in m.3243 A>G fibroblasts. …”