Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Two Polymorphic Polyoxometalate-Based Metal–Organic Frameworks for the Efficient Synthesis of Functionalized Sulfoxides and Detoxification of Mustard Gas Simulants by Yanhong Chen (304926)

“…<b>1-β</b> can be seen as a rotational polymorph of <b>1-α</b>, that is, <b>1-α</b> takes the <i>b</i> axis as the rotation axis and rotates ∼39° clockwise to obtain <b>1-β</b>. …”

An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit <i>KRAS</i> Mutant Cancer Cell Growth by Pelin Kaya (6173537)

“…These inhibitors suffered from low solubility and suspected off-target effects, preventing their clinical development. Here, we developed a highly soluble, low nanomolar PDE6D inhibitor (PDE6Di), Deltaflexin3, which has the lowest off-target activity as compared to three prominent reference compounds. …”

An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit <i>KRAS</i> Mutant Cancer Cell Growth by Pelin Kaya (6173537)

“…These inhibitors suffered from low solubility and suspected off-target effects, preventing their clinical development. Here, we developed a highly soluble, low nanomolar PDE6D inhibitor (PDE6Di), Deltaflexin3, which has the lowest off-target activity as compared to three prominent reference compounds. …”

Fast and Strong Carbon Nanotube Yarn Artificial Muscles by Electro-osmotic Pump by Xinghao Hu (2811637)

“…We demonstrate an electrochemically powered gel-elastomer-yarn muscle adhesive that generates and delivers muscle-contraction-mimicking stimulation to a target tissue.…”

Osteogenic Potential and Long-Term Enzymatic Biodegradation of PHB-based Scaffolds with Composite Magnetic Nanofillers in a Magnetic Field by Lada E. Shlapakova (13200592)

“…Six-month biodegradation caused a reduction in surface potential (1.5-fold) and in a vertical piezoresponse (3.5-fold) of the Fe₃O₄–GO scaffold because of a decrease in the PHB β-phase content. …”

Clustering analysis of total and active RNAP II at genes during the transition from G1 to G2. by Douglas Maya-Miles (7024967)

Image_1_Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner.tif by Matthew T. Ollerton (14065902)

“…Follicular regulatory CD4⁺ T cells (TFR) limit TFH numbers and function in vitro and in vivo. We evaluated the hypothesis that TFR suppress HIV replication in TFH using a well-established model of ex vivo HIV infection that employs tonsil cells from HIV uninfected individuals spinoculated with CXCR4- and CCR5-tropic HIV-GFP reporter viruses. …”

Association of covariates and COPD risk. by Yushan Shi (16440272)

“…</p><p>Conclusion</p><p>Our findings suggest a potential link between increased dietary niacin intake and a decreased prevalence of COPD.…”

Data underlying Figs 1–6 and S1–S8. by Yuhao Li (1559569)

“…Although sequentially-infected mice exhibited increased systemic immune activation and T cell responses after intramuscular and intranasal SARS-CoV-2 immunization, we observed decreased vaccine-induced antibody responses in these animals. …”

Baseline characteristics. by Lavanya Huria (12488093)

“…For instance, in Indonesia, a high TB burden country, TB case notifications decreased by 14% and treatment coverage decreased by 47% during COVID-19. …”

COVID-19 restrictions. by Lavanya Huria (12488093)

“…For instance, in Indonesia, a high TB burden country, TB case notifications decreased by 14% and treatment coverage decreased by 47% during COVID-19. …”

Delays throughout the care cascade. by Lavanya Huria (12488093)

“…For instance, in Indonesia, a high TB burden country, TB case notifications decreased by 14% and treatment coverage decreased by 47% during COVID-19. …”

DataSheet_1_Rapid changes in the surface carbonate system under complex mixing schemes across the Bering Sea: a comparative study of a forward voyage in July and a return voyage in... by Wei Yang (109917)

“…However, the seasonal evolution of the carbon cycle and its controls are less clear due to the lack of observations. Here, we present the carbonate data collected during a forward voyage in July and a return voyage in September 2018 across the Bering Sea. …”

An <i>Escherichia coli</i> Strain, PGB01, Isolated from Feral Pigeon Faeces, Thermally Fit to Survive in Pigeon, Shows High Level Resistance to Trimethoprim by Arvind Kumar (227201)

“…This loss of interaction entails decrease in affinity of TMP for PGB01-DfrA7 compared to TMP-sensitive-Dfr.…”

<i>Drosophila</i> Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function by Alexandra Vaccaro (148308)

“…Here we examined the effects of clock disruptions on locomotor aging and longevity in <i>Drosophila</i>. …”

Table_2_[18F]FDG PET/CT Studies in Transgenic Hualpha-Syn (A53T) Parkinson’s Disease Mouse Model of α-Synucleinopathy.DOCX by Rommani Mondal (10971912)

“…We report findings on metabolic changes using [¹⁸F]FDG PET/CT in the Hualpha-Syn (A53T) PD mouse model in comparison to non-carrier mice. …”

Immunization with Hypoallergens of Shrimp Allergen Tropomyosin Inhibits Shrimp Tropomyosin Specific IgE Reactivity by Christine Y. Y. Wai (653893)

“…<div><p>Designer proteins deprived of its IgE-binding reactivity are being sought as a regimen for allergen-specific immunotherapy. …”