Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa by Andrej Emanuel Cotman (5203904)

“…Starting from DNA gyrase inhibitor <b>1</b>, we identified compound <b>27</b>, featuring a 10-fold improved aqueous solubility, a 10-fold improved inhibition of topoisomerase IV from A. baumannii and P. aeruginosa, a 10-fold decreased inhibition of human topoisomerase IIα, and no cross-resistance to novobiocin. …”

A model for androgen-sensitized apoptosis of HPr-1AR. by Congcong Chen (796149)

“…However, the multi-target regulation of BCL2 family proteins by AR signaling may sufficiently stress the mitochondria towards a pro-apoptotic state (i.e., leaky outer membrane) and decrease the threshold for other apoptotic stimuli to further enhance permeabilization of the mitochondrial outer membrane above the necessary threshold for initiator and executioner caspase activation (caspase-9 and caspase-3, respectively) and apoptotic disassembly of the cells.…”

Post-fire recovery of a dense ombrophylous forest in Amazon by DÁRLISON F.C. DE ANDRADE (6879104)

“…<div><p>Abstract: The fires that occur in the Amazon are as damaging as the deforestation is. There is a need for further long-term studies on dynamics of tree communities in forests affected by fires. …”

Testing for soil-transmitted helminth transmission elimination: Analysing the impact of the sensitivity of different diagnostic tools by Marleen Werkman (543388)

“…However, the impact of using qPCR on elimination thresholds is yet to be investigated. In this paper, we aim to quantify how the sensitivity of these two diagnostic tools affects the optimal prevalence threshold at which to declare the interruption of transmission with a defined level of confidence. …”

The workflow of this study. by Juan Hu (676613)

“…Serum miR-106a-5p derived from liver fibrosis was decreased compared with healthy individuals. …”

Univariate linear regression analysis of scales. by Xiangyu Wang (341093)

“…Moreover, Life Sciences & Medicine students demonstrated a greater tendency toward negative self-perception, low psychological well-being level, and decreased creative self-efficacy, compared to peers in other disciplines.…”

The MELD-Plus: A generalizable prediction risk score in cirrhosis by Uri Kartoun (4535194)

“…We then used a regularized logistic regression to select the most informative variables and created a risk score that comprises the selected variables. …”

MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer by Beiqin Yu (425867)

“…Subsequently, we identified cholecystokinin B receptor (CCK-BR) as a direct target of miR-148a using western blot and luciferase activity assay. …”

Mood training resilience. by Vasileios Mantas (16949352)

Formation and Dynamics of Waves in a Cortical Model of Cholinergic Modulation by James P. Roach (785792)

“…A further decrease in ACh leads to a high degree of synchrony within traveling waves. …”

The COVID pandemic in Chile: Own construction using administrative data from the Ministry of Health. by Raimundo Atal (18272064)

An example of the descriptors of an unsymmetrical distribution. by Gerhard Fritsch (405224)

Main results using crosswalk between EQ-3D-5L and EQ-3D-3L for Chile. by Raimundo Atal (18272064)

Changes in hypoxia level of CT26 tumors during various stages of development and comparing different methods of hypoxia determination by Łukasz Kiraga (5368439)

“…</p><p>Our results showed that tumor hypoxia at molecular level was relatively high at early stage of tumor development as reflected by initially high <i>HIF1A</i> and <i>VEGFA</i> expression levels and their subsequent decrease. …”

Difference in chaos suppression in sparsely-connected E-I network. by Rainer Engelken (5266057)

“…<p>λ₁ as a function of <i>I</i>₁ for common and independent inputs, showing a monotonic decrease with <i>I</i>₁ and a larger zero-crossing for common input. …”

Image1_A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.TIF by Meng-meng Liu (18241785)

“…For the drug targets that showed significant results, further analysis was done using Summary-data-based Mendelian Randomization (SMR) and colocalization techniques. We performed a mediation analysis to identify potential mediators between HMG-CoA reductase (HMGCR) and RCS.…”

Table1_A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.DOCX by Meng-meng Liu (18241785)

“…For the drug targets that showed significant results, further analysis was done using Summary-data-based Mendelian Randomization (SMR) and colocalization techniques. We performed a mediation analysis to identify potential mediators between HMG-CoA reductase (HMGCR) and RCS.…”

Table2_A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.XLSX by Meng-meng Liu (18241785)

“…For the drug targets that showed significant results, further analysis was done using Summary-data-based Mendelian Randomization (SMR) and colocalization techniques. We performed a mediation analysis to identify potential mediators between HMG-CoA reductase (HMGCR) and RCS.…”

Image2_A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.TIF by Meng-meng Liu (18241785)

“…For the drug targets that showed significant results, further analysis was done using Summary-data-based Mendelian Randomization (SMR) and colocalization techniques. We performed a mediation analysis to identify potential mediators between HMG-CoA reductase (HMGCR) and RCS.…”

Image3_A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.TIF by Meng-meng Liu (18241785)

“…For the drug targets that showed significant results, further analysis was done using Summary-data-based Mendelian Randomization (SMR) and colocalization techniques. We performed a mediation analysis to identify potential mediators between HMG-CoA reductase (HMGCR) and RCS.…”