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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…Furthermore, circular dichroism spectroscopy experiments using recombinant CaM proteins reveals a decreased structural stability of the four mutants compared to the wild-type CaM protein in the presence of Ca2+. …”
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870
Optimal virtual network function placement in multi-cloud service function chaining architecture
Published 2017“…Greedy approach has already been widely studied in the literature for the VM placement problem. Especially we compare our proposed heuristic with a greedy approach using first-fit decreasing (FFD) method. …”
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871
Investigating the utilization of healthcare services to manage respiratory tract infections (RTIs) among Qatari patients attended selected primary healthcare centers in Qatar
Published 2018“…Highest number of patients with a comorbidity of Diabetes (12.85%), followed by Hypertension (10.54%). …”
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872
Magnetorheological elastomer-based variable stiffness flexible coupling for vibration isolation
Published 2021“…MRE samples with 40% volume fraction were fabricated and manufactured using a 3D mold design and fixed within a coupling in a shaft to investigate the effects of magnetic fields on the torsional rigidity. …”
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Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021
Published 2024“…In the same period, PUV increased in central Europe, eastern Europe, and central Asia by 116·1% (8·0–218·2). Our forecasts predict a continued global decline in HIV incidence and mortality, with the number of people living with HIV peaking at 44·4 million (40·7–49·8) by 2039, followed by a gradual decrease. …”
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Development of Internally Pressurized Composite/Metallic/Composite Hybrid Pipes
Published 2021“…Both corrosion and abrasion cause significant losses and decrease the structural integrity of pipelines. This work proposes a corrosion-free hybrid pipe, which will improve the pipeline’s pressure capacity and eliminate internal and external corrosion. …”
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