NPB304 affected P-gp function and increased paclitaxel accumulation in P-gp-overexpressing resistant cells and tumor tissue. by Mei Mei (610571)

“…(C) NPB304 treatment promoted bidirectional permeability but decreased the efflux ratio of paclitaxel in a Caco-2 monolayer model. …”

TGFβ pathway is involved in the regulation of VEGF-C expression in TGFβ1 sensitive NSCLC lines. by Lincan Duan (4996736)

“…The presence of 0.1 μM LY2157299 significantly reduced TGFβ1-induced VEGF-C expression. <b>(D)</b> Similarly, siRNA targeting TGFβR1 significantly decreased TGFβ1-induced VEGF-C expression compared to scramble control (*** P<0.001).…”

DataSheet_1_Coix Seed Oil Exerts an Anti–Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis.zip by Ting Fang (155126)

“…<p>Coix Seed Oil (CSO) possesses a wide range of pharmacological activities. Kanglaite Injection, a commercial product of CSO, has been used clinically as an anticancer drug in China for decades. …”

Mouse Strain-Specific Differences in <i>Irf3</i> mRNA and Protein Levels by Oleg Garifulin (273081)

“…<div><p>(A) The majority of C57BL/6ByJ BMM <i>Irf3</i> transcripts retain intron 5 (upper band), whereas in both C57BL/6J and BALB/cByJ strains most of <i>Irf3</i> pre-mRNA is properly spliced.…”

The ratio of APP localized in lipid rafts was higher in the CHO PS1 ΔE9 cells than in the CHO PS1 WT cells. by Yoon Young Cho (838272)

“…Note that CHO PS1 ΔE9 cells showed decreased APP levels than CHO PS1 WT cells. (<b>e</b>) The densitometric analysis of the ratio of APP in each fraction (n = 5). …”

Table_1_Coix Seed Oil Exerts an Anti–Triple-Negative Breasty Cancer Effect by Disrupting miR-205/S1PR1 Axis.docx by Ting Fang (155126)

“…<p>Coix Seed Oil (CSO) possesses a wide range of pharmacological activities. Kanglaite Injection, a commercial product of CSO, has been used clinically as an anticancer drug in China for decades. …”

Supplementary Material for: Expression of β-1,4-galactosyltransferases during Aging in <b><i>Caenorhabditis elegans</i></b> by Kremer J. (9621569)

“…On the other hand, expression of <i>sqv-3 (B4GALT7)</i> and of <i>W02B12.11 (B4GALT5/6)</i> appears decreased or constant, respectively, in all backgrounds during aging. …”

Positive feedback on osteoclast formation is critical for obtaining oscillations with increasing amplitude. by Timur Akchurin (377722)

“…C) Simultaneously increasing the value of parameter <i>k</i>₆ and decreasing the value of parameter <i>k</i>₅ allows simulation of experimental observation that the first peak is generally lower in experiments where osteoclasts oscillate with increasing amplitude compared to experiments without oscillations or with damped oscillations of osteoclasts. …”

siRNA-mediated knockdown of selected IGCs impairs GSC viability. by Julia Pollak (234075)

“…CellTiter-Glo viability assay 72 hours following siRNA-mediated knockdown of IGCs. GSC viability decreased in response to increasing amounts of siRNA (2, 5, and 20 pmol). …”

Image_2_Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.tif by Evan Craig (4025492)

“…It is, therefore, imperative that more effective drug formulations with decreased toxicity profiles are developed. Previous studies had shown that 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide (also called Retro-2) has efficacy against Leishmania infections. …”

Mapping of mCD137 CRDs binding to mCD137L by ELISA assay. by Ling Yi (184648)

“…Affinity-purified mCD137L (1 µg/ml) was coated on plastic, followed by adding expressed supernatants of mCD137 fragments and subsequently detected by HRP-goat-anti-human IgG. (D) A quantitative binding ELISA in which mCD137L was coated with 1 µg/ml; after blocking with milk, four purified mCD137 protein fragments (mE,mE4,mE3,mE2 ) were added with decreased concentrations 10 µg/ml, 5 µg/ml, 1 µg/ml, 0.1 µg/ml and detected by HRP-goat-anti-human IgG. …”

Image_3_Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.tif by Evan Craig (4025492)

“…It is, therefore, imperative that more effective drug formulations with decreased toxicity profiles are developed. Previous studies had shown that 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide (also called Retro-2) has efficacy against Leishmania infections. …”

Data_Sheet_1_Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo.pdf by Florian Gabel (8475108)

“…After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human. These active compounds are inactivated by the same UDP-glucuronosyltransferase isoforms as those involved in the metabolism of morphine. …”

Message for SAG1 and BAG1 ±ATc for 4 or 24 hours of culture and immunofluorescence analyses for BAG1, SAG1, SRS9, and Dolichos. by Samuel L. Hutson (236870)

“…<p>(A) Increased message for BAG1 and decreased message for SAG1 -ATc at 24 hours. …”

Partitioning Detectability Components in Populations Subject to Within-Season Temporary Emigration Using Binomial Mixture Models by Katherine M. O’Donnell (702807)

“…We fit our model and a standard binomial mixture model to counts of terrestrial salamanders surveyed at 40 sites during 3–5 surveys each spring and fall 2010–2012. …”

DataSheet_1_Immunophenotype associated with high sustained antibody titers against enzyme replacement therapy in infantile-onset Pompe disease.pdf by Ankit K. Desai (9214082)

“…B cells were increased in HSAT patients with a decreased fraction of unswitched memory B cells. …”

Supplementary Material for: Chronic Kidney Disease Results in Deficiency of ABCC6, the Novel Inhibitor of Vascular Calcification by Lau W.L. (4144549)

“…Additionally, plasma levels of the calcification inhibitor fetuin-A were significantly decreased in CKD animals compared to controls. …”

Image_4_Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.tif by Evan Craig (4025492)

“…It is, therefore, imperative that more effective drug formulations with decreased toxicity profiles are developed. Previous studies had shown that 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide (also called Retro-2) has efficacy against Leishmania infections. …”

Data from nutrients and herbivores impact grassland stability across spatial scales through different pathways by Qingqing Chen (10662878)

“…It is also unclear whether nutrients and herbivores impact stability via different facets of plant diversity including species richness, evenness, and changes in community composition through time and space. We used a replicated experiment adding nutrients and excluding herbivores for 5 years in 34 global grasslands to explore these questions. …”

Redd1 inhibits β-catenin action. by Qiang Feng (88137)

“…Representative view of <i>gfp</i> mRNA-, <i>β-catenin ΔN</i> mRNA-, and <i>β-catenin ΔN</i> mRNA <i>+ redd1</i> mRNA-injected embryos at 5 somite stage is shown in A). Scale bar = 200 µm. …”