Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Original data (a, b, c, d) and disproportionality analysis results (ROR & IC). by Mengsi Peng (12882734)

Inhibition of NFAT activity with CsA and INCA-6 decreases CASQ2 mRNA synthesis in neonatal cardiomyocytes. by Rafael Estrada-Avilés (4424278)

Lipopolysaccharide (LPS) treatment decreases the density of neurons in the ischemic cortical region after stroke in a microglia-dependent manner. by Eric Yuhsiang Wang (17131666)

Mutant channel with deletion of the S10 region has decreased surface expression in a stable HEK293 cell line. by Shumin Bian (191969)

“…Surface to total ratios were obtained by integration of the histograms. There is a 40% decrease in surface protein expression for the HSloΔS10 mutant determined by the surface to total HSlo ratio (+/− SEM, p = 0.032 in two sample t-test .n = 5).…”

Human cerebral organoids treated with VPA show a decreased size, impaired neurogenesis, and induction of senescence in NE cells. by Muriel Rhinn (406515)

Targeted point mutation (F639A) in the GluN1 subunit decreases ethanol sensitivity of NMDA receptors. by Carolina R. den Hartog (484817)

Fig 2D–2F Data. by Kevin D. Gaitonde (15411707)

“…We observed a marked decrease in nocturnal locomotion of <i>Opn5</i>^<i>cre</i><i>; Gnas</i>^<i>fl/fl</i> mice at both 28°C and 22°C, but no overall differences in energy expenditure, respiratory exchange, or food and water consumption. …”

<i>Nf1</i> OPG mice exhibit decreased hole poking in response to a novel holeboard apparatus. by David F. Wozniak (78177)

“…(C) <i>Nf1</i> OPG mice also showed a trend toward decreased general ambulatory activity although this difference was also not significant (p = 0.053). …”

Distinct effects on calcium channel activation of <i>CACNA1I</i> disease-associated amino acid substitutions A398E/V and M1425V/I. by Yousra El Ghaleb (22075892)

Subjects:

shRNA-mediated knockdown of syntaxin-4 (Syn4) decreases expression of KCa2.3 at the plasma membrane (PM) in HeLa cells. by Claudia A. Bertuccio (309866)

“…Knockdown of Syn4 was confirmed by immunoblot (bottom blot and panel <b>(D)</b>). Tubulin was used as a loading control. …”

Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model-6 by Hong Yang (37298)

“…<p><b>Copyright information:</b></p><p>Taken from "Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model"</p><p>http://www.molecularpain.com/content/4/1/8</p><p>Molecular Pain 2008;4():8-8.…”

HLA-C expression levels increase and exon 1 skipping decreases as NK cells mature. by Hongchuan Li (375905)

Inhibition of SKI-1/S1P enzymatic activity using PF-429242 impairs activation of the SREBP pathway and correlates with a dramatic decrease in lipid droplet number and area. by Anastasia Hyrina (3860455)

Decreased biomechanical stability of bones from <i>Col1a1-Krm2</i> transgenic mice. by Jochen Schulze (365258)

“…(C) µCT scanning of the femora showing reduced cortical thickness and impaired mineralization (scale bars, 500 µm). (D) Cortical thickness (C.Th.) and bone mineral density (vBMD) are decreased in <i>Col1a1-Krm2</i> transgenic mice compared to wildtype littermates. …”

A complete mandible of a new amphisbaenian reptile (Squamata, Amphisbaenia) from the late middle eocene (Bartonian, Mp 16) of France by Andrej čerňanský (688565)

“…</p><p>http://zoobank.org/urn:lsid:zoobank.org:pub:17454922-A121-447F-9D01-E4992ADB7D60</p><p>SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at <a href="http://www.tandfonline.com/UJVP" target="_blank">www.tandfonline.com/UJVP</a></p></div>…”

Decreased FOXP3 Treg induction in LAG-3 KO T-cells in an <i>in vivo</i> self-tolerance. by Nicholas M. Durham (174371)

Depletion of Atg5 increases the accumulation of APP in response to IDN5706. by Viviana A. Cavieres (500139)

Inhibition of viral replication of 6:2 Tky/05 in haematopoetic cells decreased both IFN-α production in lung and disease severity. by Hui Li (32376)

Water soaking of fruit incubated in (A) deionized water, (B) CaCl₂, (C) CuCl₂, and (D) FeCl₃. by Grecia Hurtado (10798260)