Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”

(+)-Usnic acid decreases mRNA level of downstream target genes of β-catenin/LEF and c-jun/AP-1. by Yi Yang (116183)

D-4F and L-5F improves blood glucose. by Kristine C. McGrath (8269155)

D-4F and L-5F improves insulin sensitivity. by Kristine C. McGrath (8269155)

The <i>P[syt^P-L]</i> mutation decreases the Ca²⁺ affinity of release and vesicular release probability, but the readily releasable pool is unchanged. by Mallory C. Shields (4474210)

“…Application of bath solution does not result in an increase in mEJP frequency in either genotype (open circles) (p = 0.57 for <i>+/-; P[syt^WT]/+</i> and p = 0.83 for <i>+/-;P[syt^P-L]/+</i>, student t-test). Scale bar 2mV, 3s. (D) Paired-pulse analysis indicates a decrease in release probability in <i>+/-;P[syt^P-L]/+</i>. …”

Blocking VIP-signaling increased expression of costimulatory molecules and decreased expression of coinhibitory molecules on lymphocytes following mCMV infection. by Jian-Ming Li (319425)

Decreased dermal and corneal stromal collagen in <i>Slc39a13</i>-KO mice. by Toshiyuki Fukada (156297)

“…Data represent mean±S.D. F. Collagen of corneal stroma is decreased in <i>Slc39a13</i>-KO mice. …”

Necdin deficiency decreases <i>p16</i> expression and increases <i>Cdk1</i> expression in primary NPCs. by Ryohei Minamide (505053)

Inhibition of ER stress-induced autophagy aggravates, while activation of ER stress-induced autophagy decreases apoptosis in HCC cells. by Yan Lei (535846)

Chronic FIV infection is associated with decreased lymphocyte numbers in Lm challenged LN. by Rita D. Simões (160722)

METH decreased basal pERK1/2 levels and potentiated ERK1/2 phosphorylation induced by 6-OHDA. by Amina El Ayadi (341955)

“…METH decreased activation of ERK 1/2 in a concentration-dependent manner (0, 0.5, and 1 mM at the 24 hr time point) and enhanced the activation of ERK1/2 after 6-OHDA exposure. …”

Vi expression decreases antibody and complement binding to <i>Salmonella</i> in the absence of specific antibodies. by Peter J. Hart (503558)

Cost-effectiveness and budget impact of immediate antiretroviral therapy initiation for treatment of HIV infection in Côte d’Ivoire: A model-based analysis by Eric N. Ouattara (6890174)

“…We projected long-term clinical and economic outcomes of immediate ART initiation in Côte d’Ivoire.</p><p>Methods</p><p>We used a mathematical model to compare three potential ART initiation criteria: 1) CD4 <350/μL (<i>ART<350/μL</i>); 2) CD4 <500/<i>μ</i>L (<i>ART<500/μL</i>); and 3) ART at presentation (<i>Immediate ART</i>). …”

Dose-dependent inhibition of V-ATPase with Bafilomycin A1 decreases LysoTracker Red fluorescence and increases Lyso-pHluorin fluorescence. by Yarden Golan (5924594)

VPS34 inhibition decreases intracellular levels of cholesteryl-esters, blocks cholesterol uptake and enhances lysosomal degradation of LDLR. by Marek J. Kobylarz (9292599)

Intratumoral injection of rVP1 attenuates subcutaneous BNL tumor growth by inducing apoptosis and decreasing the level of CCL2. by Tai-An Chen (211390)

Loss of <i>SLC4A11</i> expression and CHED-associated <i>SLC4A11</i> mutations in hCEnC lead to decreased cell viability during tBH-induced oxidative stress. by Doug D. Chung (3611387)

Exposure to glucocorticoids decreases the levels of pAMPK and GR in cultured rat prefrontal cortical astrocytes. by Shi-Ying Yuan (2937669)

AMPK activators reverse the decreased expression of GR induced by DEX in cultured prefrontal cortical astrocytes. by Shi-Ying Yuan (2937669)

“…<p>(A) Representative western blot images (upper) and summarized data (lower) showing the effects of AICAR (n = 5 for each group) (A), ASP (n = 4 for each group) (B), and MET (n = 7 for each group) (C) on DEX-induced decreases of GR and pAMPK in cultured astrocytes. …”

rRL-KD treatment decreased inflammation after MSU-induced acute gout arthritis. by Fábio Mambelli (10005409)