Effect of salt intake and potassium supplementation on brachial-ankle pulse wave velocity in Chinese subjects: an interventional study by Y. Wang (473169)

“…Forty-nine subjects (28-65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a low-salt diet for 7 days (3.0 g/day NaCl), a high-salt diet for an additional 7 days (18.0 g/day NaCl), and a high-salt diet with potassium supplementation for a final 7 days (18.0 g/day NaCl+4.5 g/day KCl). …”

Data_Sheet_1_Investigation of the genetic effect of 56 tobacco-smoking susceptibility genes on DNA methylation and RNA expression in human brain.docx by Zhongli Yang (9750611)

“…An eQTL was revealed to significantly affect EGLN2 expression in the European sample and two mQTLs were respectively detected in CpG sites in NRXN1 and CYP2A7. Interestingly, we found for the first time that the minor allele of the single nucleotide polymorphism (SNP) rs3745277 located in CYP2A7P1 (downstream of CYP2B6) significantly decreased methylation at the CpG site for CYP2A7 (cg25427638; P = 5.31 × 10^–7), reduced expression of CYP2B6 (P = 0.03), and lowered the percentage of smokers (8.8% vs. 42.3%; Odds Ratio (OR) = 0.14, 95% Confidence Interval (CI): 0.02–0.62; P = 4.47 × 10^–3) in a dominant way for the same cohort sample. …”

Presentation_1_Investigation of the genetic effect of 56 tobacco-smoking susceptibility genes on DNA methylation and RNA expression in human brain.PPTX by Zhongli Yang (9750611)

“…An eQTL was revealed to significantly affect EGLN2 expression in the European sample and two mQTLs were respectively detected in CpG sites in NRXN1 and CYP2A7. Interestingly, we found for the first time that the minor allele of the single nucleotide polymorphism (SNP) rs3745277 located in CYP2A7P1 (downstream of CYP2B6) significantly decreased methylation at the CpG site for CYP2A7 (cg25427638; P = 5.31 × 10^–7), reduced expression of CYP2B6 (P = 0.03), and lowered the percentage of smokers (8.8% vs. 42.3%; Odds Ratio (OR) = 0.14, 95% Confidence Interval (CI): 0.02–0.62; P = 4.47 × 10^–3) in a dominant way for the same cohort sample. …”

Supplementary Material for: Post-operative severity assessment in sheep by Zentrich E. (13103193)

“…Methods: Telemetric devices were implanted in a first surgery subcutaneously into four German blackheaded mutton ewes (4-5 years, 77-115kg). …”

Generation of <i>fgf22</i> knockout mice. by Monika Jarosz (156537)

“…<i>Fgf22</i> wt (+/+) samples show a single band at 286 bp (mice 1, 3 and 4), <i>fgf22</i> ko (−/−) display a single ko allele at 130 bp (mice 2 and 7) and heterozygous (+/−) samples amplify both wt and ko alleles (mice 5, 6 and 8). …”

Phytochemical analysis and fungicide potential of Pouteria ramiflora against Lasiodiplodia theobromae by Ademir Kleber M Oliveira (4771896)

“…The experimental design was completely randomized with five replications, and the treatments were constituted of a factorial of seven extracts/fractions and six concentrations. …”

Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling by Mariliis Tark-Dame (641719)

“…PLoS ONE 5: e12218.). We show that compaction can be explained by selectively decreasing the number of short-range loops, leaving long-range looping unchanged. …”

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation by Crina-Maria Ionescu (158447)

“…The network was mediated by a hub of three residues on helix 5 of the hydrophobic core of Bax. …”

Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis by VANESSA S. MACHADO (10365432)

“…HG-OLAS and HG-NCAS formulations decreased ear edema induced by UVB radiation (0.5 J/cm2), with maximum inhibitions of 68±6% and 76±2% compared to the UVB radiation group, respectively. …”

CRISPRi knockdown of candidate macrophage pathogenesis genes. by Dustin R. Long (11565529)

“…Boxes indicate median, 25^th, and 75^th percentiles with whiskers extending to the most distant value < 1.5 times the interquartile range. Red horizontal lines indicate the 95% confidence interval of all control measurements from JE2 with GFP-targeted CRISPRi, with significant mutants defined as having a median measurement outside this range. …”

Supplementary Material for: Postmortem Biopsy to Obtain Lung Tissue in Congenital Diaphragmatic Hernia by Van Loenhout R.B. (4136656)

“…<b><i>Background:</i></b> The accrual of human tissues from autopsies for diagnostic and translational research has decreased significantly over the last decades. <b><i>Objectives:</i></b> The objective of this study was to evaluate our experience with lung biopsy through a minithoracotomy as an alternative for obtaining postmortem tissue when full autopsy is refused in congenital diaphragmatic hernia (CDH) patients. …”

Co-transport of VP26-GFP particles and APP-mRFP in live cells. by Shi-Bin Cheng (226400)

“…<p>(A) The first frame of a video sequence captured at 7–9 hr p.i. captured at 3-sec intervals for 900 sec (15 min). …”

Potential of the coffee endophytic <i>Bacillus cereus sensu lato</i> strain CCBLR15 to control the plant-parasitic nematode <i>Radopholus duriophilus</i> by Benoit Duong (9724226)

Over-expression of Fas2 in the wing imaginal disc causes an EGFR-dependent reduction in organ size. by Luis Garcia-Alonso (152388)

“…At right, a clone in the Posterior compartment between vein V and the posterior wing margin (green arrow) causes an abnormal shape due to the reduction in size of the posterior region of the wing, while another clone between veins II and III causes a size decrease in the anterior compartment (green arrow). …”

Effects of TNF-α and atRA on matrix gene expression by Jason S Rockel (18877)

“…Panels b to d: data are ratios of matrix gene: transcript levels normalized as a fraction of the ratios in untreated cultures (first bar), and are expressed as means ± standard error (the number of independent experiments was seven for panel b, five for panel c, and five for panel d). …”

Image_1_Comparative Genomics Reveals Accelerated Evolution of Fright Reaction Genes in Ostariophysan Fishes.jpeg by Liandong Yang (3474386)

“…These differentially expressed genes were shown to be evolved accelerated under the influence of positive selection, indicating that protein-coding evolution has played a major role in fright reaction. We found the basal vomeronasal type 2 receptors (v2r) gene, v2rl1, displayed significantly decrease expression after fright reaction, which suggests that v2rs may be important to detect the alarm substance and induce the fright reaction. …”

Video_1_Comparative Genomics Reveals Accelerated Evolution of Fright Reaction Genes in Ostariophysan Fishes.mp4 by Liandong Yang (3474386)

“…These differentially expressed genes were shown to be evolved accelerated under the influence of positive selection, indicating that protein-coding evolution has played a major role in fright reaction. We found the basal vomeronasal type 2 receptors (v2r) gene, v2rl1, displayed significantly decrease expression after fright reaction, which suggests that v2rs may be important to detect the alarm substance and induce the fright reaction. …”

DataSheet_1_Comparative Genomics Reveals Accelerated Evolution of Fright Reaction Genes in Ostariophysan Fishes.xlsx by Liandong Yang (3474386)

“…These differentially expressed genes were shown to be evolved accelerated under the influence of positive selection, indicating that protein-coding evolution has played a major role in fright reaction. We found the basal vomeronasal type 2 receptors (v2r) gene, v2rl1, displayed significantly decrease expression after fright reaction, which suggests that v2rs may be important to detect the alarm substance and induce the fright reaction. …”

Foxp3-positive cells in the thymus. by Elke Kuypers (127094)

“…<p>Representative images for Foxp3 expression in the thymus are shown for controls (<b>A</b>), 14 d LPS (<b>B</b>), and 14 d LPS+7 d Beta group (<b>C</b>). …”

The effect of annexin-1 peptide Ac2-26 on TNFα-induced NF-κB promoter activity in HMECs. by Hitesh M. Peshavariya (406738)

“…<p>TNFα (20 ng/ml) induced NF-κB promoter activity is decreased by pretreatment of Ac2-26 (0.5 µM) and diphenyleneiodonium (DPI, 1 µM). …”