Gfap typically increases with disease progression but decreases in some models in advanced stages of degeneration. by Claire Hippert (171005)

“…<i>Pde6b</i>^{<i>rd1/rd1</i>} animals showed a bimodal pattern of Gfap synthesis, with staining being particularly strong at the mid stage, but decreasing thereafter (i-vi). …”

mPEG PV1-Fab’ treatment decreases T_reg population. by Pedro Henrique Papotto (791904)

Simvastatin decreases cerebral vasospasm of the middle cerebral artery and reduces microthromboemboli after SAH. by Mohammed Sabri (355717)

“…Scale bar is 100 µm. <b>D</b> and <b>E</b>. Both pre-SAH and post-SAH treatment with simvastatin significantly decrease microthromboemboli in both cerebral cortex (<i>P</i><0.001) and hippocampus (<i>P</i><0.01) as compared to vehicle treated group. …”

Nasal mucociliary clearance was decreased in <i>Ttll1</i>^−/− mice. by Toshiyuki Iwata (419270)

“…<p>(A) Tosufloxacin (50 mg/kg) was administered to <i>Ttll1</i>^−/− mice with rhinosinusitis to inhibit cough for 7 days. …”

Behavioral response to ambiguous conditioned fear cues is decreased in adult neurogenesis-deficient mice. by Lucas R. Glover (3912628)

Atorvastatin decreases ER Stress signaling and apoptosis in Ang II-induced AAA in vivo. by Yuanyuan Li (18671)

GBE did not modify cell morphology but decreased reactive oxygen species (ROS) levels. by Virginie Rhein (243241)

“…<b>D</b>) ROS levels (DHR fluorescence units/1×10⁵ cells normalized to the respective untreated control and APP cells = 100%) were significantly decreased after treatment with GBE (100 µg/ml; 24 h). …”

Treatment with TDF decreased cell viability and induced morphological changes in hepatic stellate cells. by Sung Won Lee (222509)

Experiments were conducted in the operant conditioning box (A, protocols 1–6) or a home cage (B, protocol 6). by Agnieszka D. Wardak (17941139)

Decreased ISCs and increased goblet cells after intestinal specific loss of MLL1. by Neha Goveas (11790822)

“…Scale bars are 100 μm for OLFM4 and 50 μm for SOX9 and Ki67. (D) Left panels; alcian blue staining of goblet cells with nuclear fast red (NFR) to stain nuclei. …”

KCl treatment increases Elk1 SUMOylation and decreases katanin-p60 expression. by Ece Selçuk (436963)

hESCs-Exo decreased cancer cell proliferation and increased cancer cell death. by Shufeng Zhou (398572)

Increased osteoblastic activity and decreased osteoclastogenesis in TgLRAP cells <i>in vitro</i>. by Naoto Haruyama (487384)

“…Compared with the co-culture of WT BMCs and WT calvarial cells (WT / WT), the number of osteoclasts were significantly decreased at 50% in the co-cultures of TgLRAP BMCs and TgLRAP calvarial cells (TgLRAP / TgLRAP) (graph). …”

Dose-dependent decrease in Top1 levels in A375 xenografts. by Thomas D. Pfister (107712)

Disruption of FGFR1-Frs2/3 pathway decreases the number of support cells. by Kazuya Ono (513633)

Exposure to low CO₂ levels decreases ER cholesterol levels. by Nityanand Bolshette (17396845)

“…<b>(C)</b> Total cholesterol quantification (with fluorometric assay kit) in NIH3T3 cells depleted with sterols for 2 h or exposed to different CO₂ levels for 4 h (mean ± SE, <i>n</i> = 3 biological replicates per condition, **<i>P</i> < 0.01, nonsignificant (ns), two-sided Student’s <i>t</i> test). <b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …”

DHT increases whereas orchidectomy decreases the weight and cross sectional area of hindlimb muscles. by Young-Eun Yoo (323357)

“…<b>A:</b> In WT mice, DHT increased the GN weight by 7% (212.4±8.8 mg), whereas orchidectomy decreased it by 14% (171.4±9.0 mg) compared with control WT mice (198.4±5.5 mg). …”

Ofd1 protection of photoreceptors from oxidative stress via decreasing ROS production. by Juan Wang (115708)

“…<p>(A) The intracellular oxidant DCFH of MNU-induced ROS in 661W cells observed by green fluorescence using Leica fluorescence microscope (with monochromatic CCD), and measured using fluorometer at wavelength of 488/525 nm. …”

Insulin ICV injection (14 mU) decreases olfactory detection in fasted rats. by Pascaline Aimé (293920)

“…Post-hoc comparisons showed that insulin ICV injections significantly decreased the olfactory detection index for both ISO 10⁻⁹ and ISO 10⁻⁸ odor dilutions (SNK, compared to NaCl for each odor # p¹<0.05; n = 18) and that the olfactory detection index is higher for ISO 10⁻⁸ compared to ISO 10⁻⁹ for each ICV treatment (SNK, § p¹<0.05; n = 18) (<i>D</i>) Insulin ICV injection (14 mU) does not change locomotor activity. …”

Loss of <i>Nf1</i> increases sleep fragmentation and decreases sleep depth. by Elizabeth B. Brown (4582978)

“…<b>D</b>. There is a significant effect of genotype on sleep duration (two-way ANOVA: F_2,312 = 46.27, <i>P</i><0.0001). …”