Complex I activity is increased in cells with elevated NQO1 levels and is decreased by rotenone. by Jiyeong Kim (433042)

Insulin ICV injection (14 mU) decreases olfactory detection in fasted rats. by Pascaline Aimé (293920)

“…Post-hoc comparisons showed that insulin ICV injections significantly decreased the olfactory detection index for both ISO 10⁻⁹ and ISO 10⁻⁸ odor dilutions (SNK, compared to NaCl for each odor # p¹<0.05; n = 18) and that the olfactory detection index is higher for ISO 10⁻⁸ compared to ISO 10⁻⁹ for each ICV treatment (SNK, § p¹<0.05; n = 18) (<i>D</i>) Insulin ICV injection (14 mU) does not change locomotor activity. …”

Bay 61–3606 sensitizes MCF-7 cells to TRAIL by decreasing Mcl-1. by So-Young Kim (562174)

Behavioral response to ambiguous conditioned fear cues is decreased in adult neurogenesis-deficient mice. by Lucas R. Glover (3912628)

Zebrafish harboring homozygous mutations in <i>gdf6</i> exhibit decreased endurance. by Michèle G. DuVal (278183)

“…</b> Open field tests of average swim velocity during 10 minutes of each hour through a circadian cycle, in tanks replicating lifetime husbandry conditions, show a lower mean movement at night (in either genotype, **p<0.01) but no difference between genotypes in any measure during day (p = 0.247) or night (p = 0.814).…”

Hsp90 inhibition decreases the adipogenic transcriptional program without any effect on cytotoxicity. by Sébastien Desarzens (547289)

Simvastatin decreases cerebral vasospasm of the middle cerebral artery and reduces microthromboemboli after SAH. by Mohammed Sabri (355717)

“…Scale bar is 100 µm. <b>D</b> and <b>E</b>. Both pre-SAH and post-SAH treatment with simvastatin significantly decrease microthromboemboli in both cerebral cortex (<i>P</i><0.001) and hippocampus (<i>P</i><0.01) as compared to vehicle treated group. …”

Elevated PE level in yeast decreases the sensitivity of replicating tombusvirus RNA to the reconstituted RNAi. by Nikolay Kovalev (184967)

“…See further details in the legends for <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006520#ppat.1006520.g001" target="_blank">Fig 1D and 1E</a>. …”

Exposure to low CO₂ levels decreases ER cholesterol levels. by Nityanand Bolshette (17396845)

“…<b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …”

Etomoxir and orlistat inhibit cell cycle progression and decreased proliferation rate in myeloma cells. by José Manuel Tirado-Vélez (304970)

TR4 and TR9 decrease hepatoma cell viability at a lower TC50 than Sorafenib, SAHA or 5-Fluorouracil. by Nicole Lange (335740)

nLTD decreases the molecular proximity between endogenous spine cofilin and F-actin by Barbara Calabrese (553229)

Aspirin decreases expression of NFκB and β-catenin in colon cancer cells. by Satya Pathi (301408)

“…<p>Decreased p65/p50 in RKO (A) and SW480 (B) cells. Cells were treated for 48 hr with 5 or 10 mM, and whole cell, nuclear and cytosolic extracts were analyzed by western blot analysis as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048208#s3" target="_blank">Experimental Procedures</a>. …”

Increased osteoblastic activity and decreased osteoclastogenesis in TgLRAP cells <i>in vitro</i>. by Naoto Haruyama (487384)

“…Compared with the co-culture of WT BMCs and WT calvarial cells (WT / WT), the number of osteoclasts were significantly decreased at 50% in the co-cultures of TgLRAP BMCs and TgLRAP calvarial cells (TgLRAP / TgLRAP) (graph). …”

Decreased ISCs and increased goblet cells after intestinal specific loss of MLL1. by Neha Goveas (11790822)

“…Scale bars are 100 μm for OLFM4 and 50 μm for SOX9 and Ki67. (D) Left panels; alcian blue staining of goblet cells with nuclear fast red (NFR) to stain nuclei. …”

Sildenafil treatment during recovery does not affect hyperoxia-induced decreases in alveolar counts. by Marta Perez (526067)

DHT increases whereas orchidectomy decreases the weight and cross sectional area of hindlimb muscles. by Young-Eun Yoo (323357)

“…<b>A:</b> In WT mice, DHT increased the GN weight by 7% (212.4±8.8 mg), whereas orchidectomy decreased it by 14% (171.4±9.0 mg) compared with control WT mice (198.4±5.5 mg). …”

GBE did not modify cell morphology but decreased reactive oxygen species (ROS) levels. by Virginie Rhein (243241)

“…<b>D</b>) ROS levels (DHR fluorescence units/1×10⁵ cells normalized to the respective untreated control and APP cells = 100%) were significantly decreased after treatment with GBE (100 µg/ml; 24 h). …”

EC50 and percentage decrease in intracellular <i>Listeria</i> viability for effective compounds. by Marie-Eve Charbonneau (5658799)

SDG decreases iron-induced oxidative stress in H9c2 cells. by Stephanie Puukila (568109)