Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine by Christine Champion (243238)

“…First, we observe an increase in the DNA binding when zebularine is incorporated into the DNA, compared to deoxycytidine and 5-fluorodeoxycytidine, together with a strong decrease in the dissociation rate. …”

Inflammation Regulates TMPRSS6 Expression via STAT5 by Delphine Meynard (87311)

“…The downregulation of Tmprss6 by inflammation in mice is not dependent on the Bmp-Smad pathway but occurs through a decrease in Stat5 phosphorylation. Moreover, Stat5 positively regulates Tmprss6 expression directly by binding to a Stat5 element located on the Tmprss6 promoter. …”

Comparative Transcriptomic Analysis of Rectal Tissue from Beef Steers Revealed Reduced Host Immunity in <i>Escherichia coli</i> O157:H7 Super-Shedders by Ou Wang (306605)

“…Functional analysis of DE genes revealed that 31 down-regulated genes were potentially associated with reduced innate and adaptive immune functions in super-shedders, including 13 lymphocytes membrane receptors, 3 transcription factors and 5 cytokines, suggesting the decreased key host immune functions in the rectal tissue of super-shedders, including decreased quantity and migration of immune cells such as lymphocytes, neutrophils and dendritic cells. …”

Chromosome segregation and organization are targets of 5′-Fluorouracil in eukaryotic cells by Laura Mojardín (478917)

“…<div><p>The antimetabolite 5′-Fluorouracil (5FU) is an analog of uracil commonly employed as a chemotherapeutic agent in the treatment of a range of cancers including colorectal tumors. …”

Expression of grapevine expansins in the V. vinifera cv Corvina atlas. by Silvia Dal Santo (268493)

Accelerated Immunodeficiency by Anti-CCR5 Treatment in HIV Infection by Ariel D. Weinberger (169848)

“…The model shows that the R5-to-X4 switch occurs as CD4⁺ T cell activation levels increase above a threshold and as CD4⁺ T cell counts decrease below a threshold during late-stage HIV infection. …”

Density of states (normalized to 2) for the π-flux square lattice model by G Mazzucchi (557358)

Replacement of intra- and extracellular chloride for D-gluconate eliminated statistically significant decreases in GLT-1 stoichiometric current and the current/flux ratio in 100–30... by Anatoli Y. Kabakov (729047)

Changing local nuclear density patterns during stage 5 by Soile VE Keränen (24218)

“…</p><p></p> Average local nuclear densities on the blastoderm surface were computed for PointCloud data derived from embryos for six consecutive time intervals spanning stage 5. …”

The ratio of absolute minimal dV/dt to maximal dV/dt is affected by the overlap level of Na⁺ and K⁺ currents. by Yuguo Yu (172221)

“…The ratio γ (defined as the ratio of absolute minimal dV/dt to maximal dV/dt) increases as a function of temperature for both classical HH neuron and cortical neuronal models, owing largely to the decrease in overlap of Na⁺ and K⁺ currents with increases in temperature. …”

CD43^-/- septic mice exhibit decreased frequencies of apoptotic CD4⁺ and CD8⁺ naïve T cells as compared to WT septic mice. by Katherine T. Fay (2576998)

“…B) CD43^-/- septic mice exhibited a decreased frequency of apoptotic naïve CD4⁺ T cells, defined as 7-AAD⁺ Annexin V⁺ CD44^LO CD62L^HI CD4⁺ cells, compared to WT septic mice (11.8±1.6 vs 18.8±1.3, p = 0.002. …”

Changes in the leaf contents of total phenols and 5-caffeoylquinic acid. by José C. Ramalho (493978)

“…<p>Values of total phenols (mg GAE g^-1 dw), and 5-caffeoylquinic acid (5-CQA) along the entire experiment for Apoatã, Icatu, and Obatã genotypes, under well-watered (WW), mild drought (MD) and severe drought (SD) conditions, and submitted to temperature control conditions (25/20 ^oC), during the gradual temperature decrease (18/13 ^oC), at the end of the acclimation period (13/8 ^oC), after 3 chilling cycles (3x13/4 ^oC), after 7 days under rewarming conditions (7x Rec Cold), and after a further 7 days period under rewatering conditions (7x Rec Drought).…”

Comparison of WT and mutant SHC014-CoV S ectodomains. by Alexandra L. Tse (20235212)

“…Area under the curve represents protein expression. A835D-containing variants exhibit a large decrease in protein expression relative to the WT and F294L SHC014-CoV spikes. …”

CBD (30 mg/kg, n = 7–9 animals/group) and HU-101 (10 mg/kg, n = 9–10 animals/group) decreased the number of buried marbles in the MBT. by Aviva Breuer (3153021)

Presentation 1_Case report: Exploring efficacy of tofacitinib in modulating interferon response in five case of anti-MDA5+ dermatomyositis with interstitial lung disease.pdf by Jie Zhao (49409)

“…<p>A case report highlights the challenges faced in managing a 66-year-old Chinese woman diagnosed with anti-MDA5 antibody-positive dermatomyositis (MDA5-DM) complicated by rapidly progressive interstitial lung disease (RP-ILD). …”

S1 data_Hazen Main and Blister 2017 absolute diatom counts from Contrasting the ecological effects of decreasing ice cover versus accelerated glacial melt on the High Arctic's larg... by Neal Michelutti (688828)

“…Increased glacial meltwater can alter the ecological functioning of recipient aquatic ecosystems via changes to nutrient budgets, turbidity and thermal regimes. Here, we examine a rare set of five high-resolution sediment cores collected in Lake Hazen between 1990 and 2017 CE to investigate the influence of increased glacial meltwater versus alterations to lake ice phenology on ecological change. …”

<i>Ctsz</i>^{<i>−/−</i>} mice have higher lung burden and earlier spleen dissemination during acute infection followed by greater chronic inflammation and mortality risk.... by Rachel K. Meade (22216529)

Comparison of Laparoscopy and vNOTES in Early-stage Endometrial Cancer by Murat Levent Dereli (17763348)

“…The requirement for additional opioid/narcotic analgesic was lower in the vNOTES group than in the CL group (p=0.037). </p><p dir="ltr">In conclusion, vNOTES may be a safe and feasible option in early-stage endometrial cancer, having less post-operative pain and less requirement of opioid/narcotic analgesic compared with laparoscopy.…”

Valve closing capability and hemolymph flow analysis. by Christian Meyer (6035)

“…Upon heartbeat hemolymph packages pass ROI1 (located anteriorly to cardiac valves), reaches peak intensity and falls down to a baseline again, indicating hemolymph transport and proper valve luminal closure in control animals and in <i>rab11</i> knockdown, <i>spectrin</i> knockdown and Rab4 overexpression lines (D-H, Scheme in D highlights characteristic timepoints of the pumped dye package passing the ROI, asterisks represent respective points in the oscillogram. …”

IRE1 depletion increases chromosome instability. by Iratxe Zuazo-Gaztelu (21071939)