Equatorenes: Synthesis and Properties of Chiral Naphthalene, Phenanthrene, Chrysene, and Pyrene Possessing Bis(1-adamantyl) Groups at the Peri-position by Koji Yamamoto (505190)

“…Chiral polycyclic aromatic hydrocarbons containing bis­(1-adamantyl) groups at the peri-positions, named equatorenes, were synthesized in optically pure form starting from optically pure 4,5-bis­(1-adamantyl)-8-methoxy-1-naphthol. A sequential Diels–Alder reaction of furan and arynes generated from 1,2-bromotriflates provided tricyclic and tetracyclic epoxides, and acid-catalyzed aromatization gave phenanthrol and chrysenol. …”

Equatorenes: Synthesis and Properties of Chiral Naphthalene, Phenanthrene, Chrysene, and Pyrene Possessing Bis(1-adamantyl) Groups at the Peri-position by Koji Yamamoto (505190)

“…Chiral polycyclic aromatic hydrocarbons containing bis­(1-adamantyl) groups at the peri-positions, named equatorenes, were synthesized in optically pure form starting from optically pure 4,5-bis­(1-adamantyl)-8-methoxy-1-naphthol. A sequential Diels–Alder reaction of furan and arynes generated from 1,2-bromotriflates provided tricyclic and tetracyclic epoxides, and acid-catalyzed aromatization gave phenanthrol and chrysenol. …”

Cep63 is needed for efficient centriole duplication in human and mouse cells. by Nicola J. Brown (380651)

“…<p>(A-B) Cep63 depletion by RNA interference (RNAi) led to decreased centriole numbers in U2OS cells. …”

Equatorenes: Synthesis and Properties of Chiral Naphthalene, Phenanthrene, Chrysene, and Pyrene Possessing Bis(1-adamantyl) Groups at the Peri-position by Koji Yamamoto (505190)

“…Chiral polycyclic aromatic hydrocarbons containing bis­(1-adamantyl) groups at the peri-positions, named equatorenes, were synthesized in optically pure form starting from optically pure 4,5-bis­(1-adamantyl)-8-methoxy-1-naphthol. A sequential Diels–Alder reaction of furan and arynes generated from 1,2-bromotriflates provided tricyclic and tetracyclic epoxides, and acid-catalyzed aromatization gave phenanthrol and chrysenol. …”

Video_1_Deletion of the Wilms’ Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development.AVI by Sandra Díaz del Moral (11170191)

“…Adult mutant mice showed electrocardiographic anomalies, including increased RR and QRS intervals, and decreased PR intervals. RNASeq analysis identified differential expression of 137 genes in the E13.5 mutant heart as compared to controls. …”

Video_2_Deletion of the Wilms’ Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development.AVI by Sandra Díaz del Moral (11170191)

“…Adult mutant mice showed electrocardiographic anomalies, including increased RR and QRS intervals, and decreased PR intervals. RNASeq analysis identified differential expression of 137 genes in the E13.5 mutant heart as compared to controls. …”

DataSheet1_Emodin Ameliorates Acute Pancreatitis-Associated Lung Injury Through Inhibiting the Alveolar Macrophages Pyroptosis.pdf by Xiajia Wu (5560334)

“…Additionally, emodin mitigated the pyroptotic process of AMs by decreasing the level of inflammatory cytokines and lactate dehydrogenase. …”

TNFα and RANKL stimulation regulates the expression of p21 in <i>Pkd1</i> wild type MEK cells. by Julie X. Zhou (760553)

“…<p>(A) Western blot analysis of the expression of Id2 and p21 from whole cell lysates of <i>Pkd1</i> wild type and null MEK cells. …”

Smad4 Regulates Ureteral Smooth Muscle Cell Differentiation during Mouse Embryogenesis by Jianyun Yan (616173)

“…We found that mice with specific deletion of <i>Smad4</i> in <i>Tbx18</i>-expressing ureteral mesenchyme exhibited hydroureter and hydronephrosis at embryonic day (E) 16.5, and the mutant mesenchymal cells failed to differentiate into SMCs with increased apoptosis and decreased proliferation. …”

Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions between HIV-1 and the Monocyte-Derived Macrophage by Stephanie D. Kraft-Terry (87700)

“…Alterations in <i>de novo</i> protein synthesis of HIV-1 infected human monocyte-derived macrophages (MDM) were examined after 3, 5, and 7 days of viral infection. Synthesis rates of cellular metabolic, regulatory, and DNA packaging activities were decreased, whereas, those affecting antigen presentation (major histocompatibility complex I and II) and interferon-induced antiviral activities were increased. …”

Table_1_Exercise Prior to Lower Extremity Peripheral Artery Disease Improves Endurance Capacity and Hindlimb Blood Flow by Inhibiting Muscle Inflammation.docx by Maxime Pellegrin (830439)

“…Here, we investigated the preventive effects of exercise on endurance capacity, hindlimb perfusion, and on polarization profile of circulating monocytes and limb muscle macrophages. ApoE^−/− mice were subjected to 5-week running wheel exercise or remained sedentary before induction of hindlimb ischemia. …”

ONO-1301 enhanced SDF-1 secretion and BMC migration via SDF-1/CXCR4 signaling after MI. by Yukiko Imanishi (435069)

“…When BMCs treated with AMD were injected, the BMC accumulation decreased in the 100 mg/Kg ONO-1301-treated infarcted heart compared with the untreated-BMC-injected heart (0 mg/Kg, n = 4; 10 mg/Kg, n = 8; 100 mg/Kg, n = 5; 100 mg/Kg+AMD3100, n = 4; *<i>P</i><0.05 vs. 0 mg/Kg, †<i>P</i><0.05 vs. 10 mg/Kg, ‡<i>P</i><0.05 vs. 100 mg/Kg).…”

Acetylation of K153 is essential for CDC42 interaction with PAK4. by Dan-Ni Wang (6443477)

“…<p>(A) Ribbon diagram showing the structure of CDC42-PAK4 (PDB-ID: 5UPK). …”

Characterization of adipocyte-specific <i>Arrdc3</i>-null mice. by Shannon H. Carroll (3836632)

“…<p>(A) To confirm adipocyte-specific deletion, Arrdc3 expression was measured in various tissues of Cre–(control) and Cre+ (<i>Arrdc3</i>-null) mice by quantitative PCR. …”

Equatorenes: Synthesis and Properties of Chiral Naphthalene, Phenanthrene, Chrysene, and Pyrene Possessing Bis(1-adamantyl) Groups at the Peri-position by Koji Yamamoto (505190)

“…Chiral polycyclic aromatic hydrocarbons containing bis­(1-adamantyl) groups at the peri-positions, named equatorenes, were synthesized in optically pure form starting from optically pure 4,5-bis­(1-adamantyl)-8-methoxy-1-naphthol. A sequential Diels–Alder reaction of furan and arynes generated from 1,2-bromotriflates provided tricyclic and tetracyclic epoxides, and acid-catalyzed aromatization gave phenanthrol and chrysenol. …”

Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions between HIV-1 and the Monocyte-Derived Macrophage by Stephanie D. Kraft-Terry (87700)

“…Alterations in <i>de novo</i> protein synthesis of HIV-1 infected human monocyte-derived macrophages (MDM) were examined after 3, 5, and 7 days of viral infection. Synthesis rates of cellular metabolic, regulatory, and DNA packaging activities were decreased, whereas, those affecting antigen presentation (major histocompatibility complex I and II) and interferon-induced antiviral activities were increased. …”

Image_2_Araloside C Prevents Hypoxia/Reoxygenation-Induced Endoplasmic Reticulum Stress via Increasing Heat Shock Protein 90 in H9c2 Cardiomyocytes.TIF by Yuyang Du (4251229)

“…AsC also inhibited H/R-induced ER stress by reducing the activation of ER stress pathways (PERK/eIF2α and ATF6), and decreasing the expression of ER stress-related apoptotic proteins (CHOP and caspase-12). …”

Image_3_Araloside C Prevents Hypoxia/Reoxygenation-Induced Endoplasmic Reticulum Stress via Increasing Heat Shock Protein 90 in H9c2 Cardiomyocytes.TIF by Yuyang Du (4251229)

“…AsC also inhibited H/R-induced ER stress by reducing the activation of ER stress pathways (PERK/eIF2α and ATF6), and decreasing the expression of ER stress-related apoptotic proteins (CHOP and caspase-12). …”

Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions between HIV-1 and the Monocyte-Derived Macrophage by Stephanie D. Kraft-Terry (87700)

“…Alterations in <i>de novo</i> protein synthesis of HIV-1 infected human monocyte-derived macrophages (MDM) were examined after 3, 5, and 7 days of viral infection. Synthesis rates of cellular metabolic, regulatory, and DNA packaging activities were decreased, whereas, those affecting antigen presentation (major histocompatibility complex I and II) and interferon-induced antiviral activities were increased. …”

Caloric restriction and weight loss are primary factors in the early tissue-specific metabolic changes after bariatric surgery by Charles Robb Flynn (7549064)