Image_1_Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.tif by Evan Craig (4025492)

“…It is, therefore, imperative that more effective drug formulations with decreased toxicity profiles are developed. Previous studies had shown that 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide (also called Retro-2) has efficacy against Leishmania infections. …”

Image_1_Pseudomonas stutzeri and Kushneria marisflavi Alleviate Salinity Stress-Associated Damages in Barley, Lettuce, and Sunflower.JPEG by Sonia Szymańska (3823558)

“…The aim of this study was to determine the effect of selected halotolerant plant growth-promoting endophytes (PGPEs, Pseudomonas stutzeri ISE12 and Kushneria marisflavi CSE9) on the growth parameters of barley (Hordeum vulgare), lettuce (Lactuca sativa), and sunflower (Helianthus annuus) cultivated under salt stress conditions. A negative effect of two higher tested salinities (150 and 300 mM NaCl) was observed on the growth parameters of all investigated plants, including germination percentage and index (decreasing compared to the non-saline control variant in the ranges 5.3–91.7 and 13.6–90.9%, respectively), number of leaves (2.2–39.2%), fresh weight (24.2–81.6%); however, differences in salt stress tolerance among the investigated crops were observed (H. annuus > H. vulgare > L. sativa). …”

Supplementary Material for: Microstructural Brain and Multivoxel Spectroscopy in Very Low Birth Weight Infants Related to Insulin-Like Growth Factor Concentration and Early Growth by Okuma C. (4138120)

“…This apparent reorganization of the developing brain offers a unique opportunity to investigate the relationship between changes in cortical anatomy, cognitive and social impairments and periods of early growth.…”

Interplay between Oxygen and Fe–S Cluster Biogenesis: Insights from the Suf Pathway by Eric S. Boyd (211262)

“…Our analysis suggests that diversification into oxygen-containing environments disrupted iron and sulfur metabolism and was a main driving force in the acquisition of accessory Suf proteins (such as SufD, SufE, and SufS) by the core SufB–SufC scaffold complex. …”

Table_2_The Characteristics and Expression Profile of Peptidoglycan Recognition Protein 2 in the Accessory Nidamental Gland of the Bigfin Reef Squid During Bacterial Colonization.p... by Hau-Wen Li (841219)

“…Moreover, recombinant slPGRP2 had a negative effect of Escherichia coli (E.coli) which inhibited bacterial growth in culture. …”

Table_2_Characteristic of Perineural Invasion in Hilar Cholangiocarcinoma Based on Whole-Mount Histologic Large Sections of Liver.docx by Si-Yuan Wang (6307619)

“…Extrahepatic and intrahepatic PNI were identified in 20 (100%) patients and 1 (5.0%) patient, respectively. Vessel density decreased in most invaded nerves presented by CD-34, which correlated with 100% of poorly differentiated and 83% of moderately differentiated tumors (P<0.008).…”

Mitofusins Mfn1 and Mfn2 are Required to Preserve Glucose- But Not Incretin-Stimulated Beta Cell Connectivity and Insulin Secretion by Eleni Georgiadou (7186817)

“…Here, we generated mice with beta cell-selective, adult-restricted deletion of the mitofusin genes <em>Mfn1</em> and <em>Mfn2 </em>(β<em>Mfn1/2 </em>dKO). β<em>Mfn1/2 </em>dKO mice displayed elevated fed and fasted glycaemia and a >five-fold decrease in plasma insulin. Mitochondrial length, glucose-induced polarisation, ATP synthesis, cytosolic and mitochondrial Ca2+ increases were all reduced in dKO islets. …”

Limited T Cell Receptor Repertoire Diversity in Tuberculosis Patients Correlates with Clinical Severity by Wei Luo (80175)

“…In addition, TB patients showed preferred usage of certain TCR types and have a bias in the usage of variable (V) and joining (J) gene segments and N nucleotide insertions.…”

BMA parameter changes across neurofeedback training runs. by Frank Scharnowski (532077)

“…The learners also showed a significantly decreasing effect of up-regulation on the bottom-up connection from the visual ROI to the cSPL (up_V-SPL). …”

Data Sheet 1_Safety assessment of tolvaptan: real-world adverse event analysis using the FAERS database.docx by Peiyang Cao (10808613)

“…Notably, strong ADE signals were detected for decreased urine osmolality [n = 5, ROR 149.74, PRR 149.7, IC (Information Component) 7.13, EBGM (Empirical Bayes Geometric Mean) 139.79], osmotic demyelination syndrome (n = 38, ROR 128.47, PRR 128.25, IC 6.92, EBGM 120.91), and pulmonary-related tumors such as bronchial metastatic carcinoma, bronchial carcinoma, metastatic small cell lung carcinoma, and small cell lung carcinoma. …”

Physiological levels of human MIC-1/GDF15 reduce weight and food intake in mice. by Vicky Wang-Wei Tsai (310159)

“…Food intake, body weight and serum levels of human MIC-1/GDF15 were measured on day 5 of infusion. (A) MIC-1/GDF15-treated MIC-1^−/− mice had an average serum MIC-1/GDF15 level of 643±67 pg/ml and weighed 95.86±0.77% of their starting body weight whilst vehicle-treated mice weighed 102.3±0.75% of their starting weight (<i>n</i> = 6/group, <i>p</i><0.01 <i>unpaired t-test</i>). …”

Table1_Tocilizumab in COVID-19: Factors Associated With Mortality Before and After Treatment.pdf by Luis Sarabia De Ardanaz (11057778)

“…<p>Tocilizumab (TCZ) has been administered in SARS-CoV-2 pneumonia but the factors associated with mortality before and after treatment remain unclear. …”

Cytokines shape the unique functional phenotype of synovial monocytes. by Bo Ruem Yoon (646404)

“…<p>PBMC or purified monocytes derived from HC were stimulated for 18 hours with the indicated TLR agonists or cytokines and expression of CD14 and CD16 were analyzed by flow cytometry. (<b>A</b>) Representative flow cytometric analysis of change in CD16 expression on monocytes (left) and bar graph showing the decreased frequency of the CD14⁺CD16⁺ monocytes after stimulation with LPS (10 ng/ml) or zymosan (Zym; 10 ug/ml) (right; n = 5). …”

Contribution of ERK isoforms to TNF-α-induced IL-8 expression. by Shinichi Namba (3350288)

“…Results are presented as mean ± SE from three independent experiments. Synovial fibroblasts isolated from three male beagle dogs were used, and each experiment was performed with cells derived from a single donor. …”

Table_1_The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time.DOCX by Li Chen (5749)

“…Results of log-rank methods showed that: (1) the mean DFS and OS times in patients with high p-JNK expression were significantly longer than those in patients with low p-JNK expression (χ² = 5.908, P = 0.015 and χ² = 6.593, P = 0.010, respectively). p-JNK expression is a significant prognostic factor that can effectively predict the survival in breast cancer patients receiving NACT. …”

Functional Trait Strategies of Trees in Dry and Wet Tropical Forests Are Similar but Differ in Their Consequences for Succession by Madelon Lohbeck (731258)

“…We evaluated whether multivariate plant strategies changed during succession, by calculating a ‘Community-Weighted Mean’ plant strategy, based on species scores on the first two PCA-axes. …”

Lung bacterial burden as measured by colony forming units (CFU) over time. by S. Anisah Alyahya (742654)

“…At all time points measured, no significant statistical differences were noted between the TV Ad35+ group, the vector control group, NC-V, and the main control group, NC-T4 (ANOVA) Boosting with Ad26-TBS at week 16 did not result in decreased bacterial burden by week 28 compared to all other groups in the study (p = 0.14, ANOVA)</p>…”

Absence of AMX-1 induces DNA damage checkpoint activation and AMX-1 is required for sensitivity upon interstrand crosslink damage. by Xiaojuan Zhang (235854)

“…<i>spr-5</i>, <i>him-18</i> or <i>ztf-8</i> were used as controls. …”

Endometrial genes and pathways associated with local trophoblast. by W. Colin Duncan (209189)

Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to <i>L</i>. <i>amazonensis</i> control mediated by P2X7 receptor and leukotriene B₄ by Mariana M. Chaves (6871907)

“…<i>amazonensis-</i>infected mice locally treated with exogenous LTB₄ showed resistance to infection, characterized by lower parasite load and smaller lesions compared to untreated P2X7^-/- mice. A similar observation was noted when infected P2X7^-/- mice were treated with IL-1β, i.e., lower parasite load and smaller lesions compared to P2X7^-/- mice. …”