Conditional knockout of SLAMF5 in CX3CR1^er cells attenuates EAE progression, reduces brain myeloid cell activation, and decreases T cell infiltration. by Laura Bellassen (22209109)

Statistics of predicted bandgaps by SVR, GBDT, RF and MLP algorithms based on a 9-dimensional feature space. by Yu Zhang (12946)

Tissue, days post-infection (dpi) and the top 10 most significant genes with increased and decreased expression with valid gene symbols for the response contrasts. by Gillian P. McHugo (8965919)

Modelled policy outcomes, with posterior values for individual nodes ranked from 1-5 across the parties - Green, Reform UK, Liberal Democrat, Conservative, and Labour, where 1 is the lowest rank and 5 is the highest. The parties are ranked for each policy node in the network (e.g., income tax), based on the direction of change (“performance indicator”) stated in the first column (e.g., lowest, highest, most, improvement). For example, a value of 5 for Green tax means that green tax is lowest under Reform UK’s policies, while a value of 1 means that green tax is highest under the Green Party’s policies.... by Richard Stafford (174326)

“…For example, a value of 5 for Green tax means that green tax is lowest under Reform UK’s policies, while a value of 1 means that green tax is highest under the Green Party’s policies. …”

Comparison of training and predicted values of compound water solubility for different machine learning models: (A) AdaBoost, (B) GBDT, (C) LGBM, (D) RF, (E) XGBoost, (F) RF, and (... by Bin Pan (742525)

Subjects:

T cells in Mtb-infected Qa-1^-/- mice have increased apoptosis and decreased ability to promote killing of Mtb by macrophages. by Yao Bian (2820964)

A summary of the included study characteristics. by Zahra Tajik (20752452)

“…There is no significant difference one month after NSPT in diabetic patients (SMD: -5.83, 95%CI: -15.5, 3.83, p = 0.237, I-square, 97.4%, random effects model, n = 2), but three (SMD: -2.44, 95%CI: -3.37, -1.15, p = 0.001, I-square, 75.9%, random effects model, n = 3) and six months (SMD: -2.41, 95%CI: -3.81, -1.01, p = 0.001, I-square, 78.7%, random effects model, n = 2) after the treatment, a significant decrease is observed in the mean GCF visfatin level. …”

The T-type channel antagonist Ni²⁺ decreases adult turtle motoneuron excitability. by Martha Canto-Bustos (634777)

Expression of lipid biosynthetic genes is decreased with polyamine depletion. by Yazmin E. Cruz-Pulido (20285238)

Silencing JARID1B decreases epithelial to mesenchymal transition (EMT). by Yung-Ting Kuo (736349)

Clinical factors affecting renal response to dulaglutide. by Sungmin Kim (628527)

Subjects:

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Rab27A deficiency caused decreased amylase release from isolated acini. by Yanan Hou (736195)

Mass-normalized work per unit distance and recovery over the step as a function of speed and slope while walking uphill. by Arthur H. Dewolf (4537918)

Effect of 5-HTR blockade on cost-based motivation. by Yukiko Hori (299784)

GFP expression decreases upon differentiation towards pancreatic progenitor cells. by Nicole A. J. Krentz (669397)