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39541
DataSheet1_Effects of the Lipid Metabolites and the Gut Microbiota in ApoE−/− Mice on Atherosclerosis Co-Depression From the Microbiota-Gut-Brain Axis.docx
Published 2022“…</p><p>Conclusion: Atherosclerosis co-depression of ApoE<sup>−/−</sup> mice of the prefrontal cortex and hippocampus lipid metabolism pathways of disorder and the changes of to the gut microbiota, which leads to abnormal white matter and synaptic dysfunction, increased gut inflammation, and decreased gut permeability, leading to the release of inflammatory cytokines, there is a strong correlation between both, it further confirmed the existence of the “microbiota-gut-brain axis.”…”
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39542
In silico screening, molecular docking, and molecular dynamics studies of SNP-derived human P5CR mutants
Published 2016“…<p>Pyrroline-5-carboxylate reductase (P5CR) encoded by <i>PYCR1</i> gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor. …”
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39543
Rhubarb Enema Attenuates Renal Tubulointerstitial Fibrosis in 5/6 Nephrectomized Rats by Alleviating Indoxyl Sulfate Overload
Published 2015“…<div><p>Aim</p><p>To investigate the effects of rhubarb enema treatment using a 5/6 nephrectomized rat model and study its mechanisms.…”
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39544
Image_5_Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction.tif
Published 2018“…At the end of sixth month after stroke onset, the GMV increase was found in the ipsilateral mediodorsal thalamus, superior frontal gyrus, and the contralateral precuneus. Across five times during a period of 6-month, a negative correlation was observed between mean GMV in the contralateral uvula, culmen, putamen, and ipsilateral tuber/tonsil and mean Fugl-Meyer (FM) score. …”
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39545
Table5_Indications and adverse events of teriparatide: based on FDA adverse event reporting system (FAERS).DOCX
Published 2024“…For osteoporosis, main AEs were pain (18.2%), fractures (12.4%), muscle spasms (7.7%), and nausea (6.5%), while glucocorticoid-induced osteoporosis AEs included fractures (24.1%), pain (13.2%), decreased bone density (9.8%), and nausea (5.1%).…”
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39546
Structural Insight into and Mutational Analysis of Family 11 Xylanases: Implications for Mechanisms of Higher pH Catalytic Adaptation
Published 2015“…<div><p>To understand the molecular basis of higher pH catalytic adaptation of family 11 xylanases, we compared the structures of alkaline, neutral, and acidic active xylanases and analyzed mutants of xylanase Xyn11A-LC from alkalophilic <i>Bacillus</i> sp. SN5. …”
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39547
Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening
Published 2022“…E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. …”
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39548
MIR-99a and MIR-99b Modulate TGF-β Induced Epithelial to Mesenchymal Plasticity in Normal Murine Mammary Gland Cells
Published 2012“…Mir-99a and mir-99b inhibition decreased TGF-β activity by inhibiting SMAD3 phosphorylation, resulting in decreased migration and increased proliferation in response to TGF-β. …”
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Supplementary Material for: Increased Calcification in Osteoprotegerin-Deficient Smooth Muscle Cells: Dependence on Receptor Activator of NF-κB Ligand and Interleukin 6
Published 2014“…<b><i>Results:</i></b> Lesion-free aortas from 12-week-old ApoE-/-OPG-/- mice had spotty calcification, an appearance of osteochondrogenic factors and a decrease of smooth muscle markers when compared to ApoE-/-OPG+/+ aortas. …”
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Table 5_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx
Published 2025“…Background<p>Chinese tongue sole (Cynoglossus semilaevis) is now a commercially important flatfish species widely farmed in China. …”
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Image_5_Characteristics and metabolic potential of biliary microbiota in patients with giant common bile duct stones.tif
Published 2023“…Decreasing tendency of conjugated bile acids were also observed. …”
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39560