Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Ubr3-mediated poly-ubiquitination of Cos2 is tightly controlled by Hh activation. by Tongchao Li (115391)

<em>In Vitro</em> and <em>Ex Vivo</em> Analysis of <em>CHRNA3</em> and <em>CHRNA5</em> Haplotype Expression by Glenn A. Doyle (209929)

“…For <em>in vitro</em> analyses, promoter haplotypes were sub-cloned into a luciferase reporter vector. When assessed in BE(2)-C cells, luciferase expression was equivalent among <em>CHRNA3</em> haplotypes, but the combination of deletion at rs3841324 and variation at rs503464 decreased <em>CHRNA5</em> promoter-derived luciferase activity, possibly due to loss of an SP-1 and other site(s). …”

Image_5_PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.TIF by Guangjin Chen (1989892)

“…Notably, the downregulation of PLAU decreased the expression of TNFRSF12A. Moreover, knockdown TNFRSF12A also inhibits cell proliferation and migration. …”

Subcutaneous injections of IL-2 expand peripheral CD4⁺CD25⁺CD127^lowFoxp3⁺ naïve and total memory Tregs. by Vedran Brezar (337452)

Data_Sheet_1_Loss of function of VdDrs2, a P4-ATPase, impairs the toxin secretion and microsclerotia formation, and decreases the pathogenicity of Verticillium dahliae.docx by Hui Ren (122548)

“…In addition, the defect of VdDrs2 impaired the synthesis of melanin and the formation of microsclerotia, and decreased the sporulation of V. dahliae. Our data indicate a key role of P4 ATPases-associated vesicle transport in toxin secretion of disease fungi and support the importance of mycotoxins in the pathogenicity of V. dahliae.…”

Neutralization potency decreases 6-months post 2^nd vaccine but breadth and potency increase after a 3^rd vaccine dose. by Carl Graham (9415779)

EZH2 and HDAC inhibitors cooperatively derepress a subset of PRC2 targets in CRPC. by Amy E. Schade (15368259)

Data and R Script: Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-ter... by Jacob Negrey (9541361)

Loss of <i>ubr3</i> leads to Hh signaling defects in the morphogenetic furrow of eye imaginal discs. by Tongchao Li (115391)

Supplementary Table 1 from A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice by Jo Waaler (1970758)

Ubr3 is required for Hh signaling and proper optic vesicle morphogenesis. by Tongchao Li (115391)

Up-regulation of Cos2 in <i>ubr3</i> mutant clones is responsible for the loss of Hh signaling. by Tongchao Li (115391)

The induced knockdown of GmCAD receptor protein encoding gene in <i>Galleria mellonella</i> decreased the insect susceptibility to a <i>Photorhabdus akhurstii</i> oral toxin by Tushar K. Dutta (9406648)

The variance profile in a sealed dendrite is a function of both the electrotonic length λ and ratio of synaptic to voltage time constants <i>τ</i>_<i>s</i>/<i>τ</i><sub><... by Robert P. Gowers (8735679)

“…For both plots the other parameters were <i>L</i> = 1000<i>μ</i>m, <i>τ</i>_<i>s</i> = 5ms, <i>σ</i>_<i>s</i> = 1mV. (a) <i>τ</i>_<i>v</i> = 10ms, (b) λ = 200<i>μ</i>m.…”

Optimal endobronchial tool sizes for targeting lung lesions based on 3D modeling by Torre M. Bydlon (295015)

“…In this manuscript we investigate the percentage of lesions that can be reached for various diameter tools if the tools remain inside the airways (i.e. endobronchial biopsy) and the distance a tool must travel “off-road” (or outside of the airways) to reach all lesions.…”

TREM-B1 crosslinking reduces CLEC-2 induced thrombocyte degranulation. by Vanessa Turowski (3180918)

“…<p>(A) Co-crosslinking of CLEC-2 and TREM-B1 with the thrombocyte specific mab 8G8 and 1E9 decreased degranulation (lower panels) compared to co-crosslinking an irrelevant antibody and 8G8 (upper panels). …”

Regression of soil respiration (Rs) and soil temperature (T) fitted models of (a) control, (b) low burn severity, and (c) high burn severity in the non-growing season. by Tongxin Hu (4217563)

Ground-State and Excited-State Structures of Tungsten–Benzylidyne Complexes by Benjamin M. Lovaasen (2081989)

“…X-ray transient absorption spectroscopic measurements of the excited-state structure of <b>1*</b> reveal that the W–C bond length is the same (within experimental error) as that determined by X-ray crystallography for the ground state <b>1</b>, while the average W–P/W–Cl distance increases by 0.04 Å in the excited state. The small excited-state elongation of the W–C bond relative to the M–E distortions found for M­(E)­L_<i>n</i> (E = O, N) compounds with analogous (d_<i>xy</i>)¹(π*­(ME))¹ excited states is due to the π conjugation within the WCPh unit, which lessens the local W–C π-antibonding character of the π*­(WCPh) lowest unoccupied molecular orbital (LUMO). …”

Data_Sheet_1_5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model.docx by Xujiao Zhou (6661499)

“…In addition, the high expression of GS and EAAT2 induced by glaucoma was downregulated by the 5-HT1A receptor agonist 8-OH-DPAT and the 5-HT1A receptor antagonist WAY-100635, respectively. …”