Inflammasome elements are important for TIN progression, and inhibition of the xanthine oxidoreductase system attenuates the development of this disease. by Matheus Correa-Costa (119464)

“…In addition, allopurinol-treated animals exhibited renoprotection, as demonstrated by decreased serum creatinine levels (G) (ANOVA test - p<0.0001, with Tukey post test *p<0.01 vs. adenine group), fibrosis deposition (H) (ANOVA test - p<0.0001, with Tukey post test *p<0.001 vs. adenine group), tubular dilation (I) (ANOVA test - p = 0.0001, with Tukey post test *p<0.01 vs. adenine group), tissue uric acid levels (J) (ANOVA test p = 0.0159, with Tukey post test *p<0.05 vs. adenine group), presence of ox-LDL (K) (ANOVA test - p = 0.0211, with Tukey post test, *p<0.05 vs. adenine group) and (L) GSH/GSSG ratio (ANOVA test - p = 0.0002, with Tukey post test *p<0.001 vs. control and allopurinol groups). n = 5 animals/group.…”

Table_1_Bacterial Modulation of the Plant Ethylene Signaling Pathway Improves Tolerance to Salt Stress in Lettuce (Lactuca sativa L.).DOCX by Jonathan Fortt (5772662)

“…We measured growth and biochemical parameters (e.g., proline content, lipid peroxidation and ROS degradation), as well as expression levels of genes involved in ethylene signaling (CTR1, EBF1) and transcription factors induced by ethylene (ERF5, ERF13). …”

Overexpression of miR-128 inhibited cell proliferation and tumor growth. by Zhu-mei Shi (329058)

“…<p>(A) U87 and U251 cells were transiently transfected with miR-SCR or pre-miR-128 precursor. …”

Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration by Victoria Begley (4670281)

“…RNA pol II profiles at 5ʹ exhibited significant alterations that were compatible with decreased elongation rates in the absence of Xrn1. …”

Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance by Lu-Ping Ren (183886)

“…As expected, DNL was increased (∼60%) in HFru-fed mice and decreased (32%) in HFat-fed mice (all p<0.05). Interestingly, associated with the upregulated lipogenic enzymes (ACC, FAS and SCD1), two (PERK/eIF2α and IRE1/XBP1) of three ER stress pathways were significantly activated in HFru-fed mice. …”

Table_1_Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial L... by Eleanor Valenzi (8508294)

“…Alveolar type I cells were dramatically decreased in both IPF and SSc-ILD, with a distinct transcriptome signature separating these cells by disease. …”

UCP-1 expression in primary cultured brown adipocytes by G-CSF via p38 MAPK pathway. by Yonggu Lee (436856)

“…<p>(A) Oil red-O staining for brown adipocytes; (B) Indictors for differentiation of brown adipocytes. …”

DataSheet_2_Ten years of coverage of trophy hunting in UK newspapers.docx by Nikita Yeomans (14213501)

“…Pro-trophy hunting articles were very uncommon overall (3.5%). Articles that described the complexity of trophy hunting decreased following Cecil and were most common in pre-Cecil broadsheets (35.7%, dropping to 30.6%) and rarest in post-Cecil tabloids (3.1%). …”

Table_2_Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial L... by Eleanor Valenzi (8508294)

“…Alveolar type I cells were dramatically decreased in both IPF and SSc-ILD, with a distinct transcriptome signature separating these cells by disease. …”

Image_3_Systemic Oxidative Stress, Aging and the Risk of Cardiovascular Events in the General Female Population.TIFF by Martin F. Bourgonje (10115305)

“…<p>Introduction: Menopause is associated with increased cardiovascular risk, in which oxidative stress plays a pivotal role. Systemic oxidative stress is reflected by decreased levels of free thiols (R-SH, sulfhydryl groups), which are key components of the extracellular antioxidant machinery. …”

Data_Sheet_1_Systemic Oxidative Stress, Aging and the Risk of Cardiovascular Events in the General Female Population.docx by Martin F. Bourgonje (10115305)

“…<p>Introduction: Menopause is associated with increased cardiovascular risk, in which oxidative stress plays a pivotal role. Systemic oxidative stress is reflected by decreased levels of free thiols (R-SH, sulfhydryl groups), which are key components of the extracellular antioxidant machinery. …”

Image_1_Systemic Oxidative Stress, Aging and the Risk of Cardiovascular Events in the General Female Population.TIFF by Martin F. Bourgonje (10115305)

“…<p>Introduction: Menopause is associated with increased cardiovascular risk, in which oxidative stress plays a pivotal role. Systemic oxidative stress is reflected by decreased levels of free thiols (R-SH, sulfhydryl groups), which are key components of the extracellular antioxidant machinery. …”

Urine Bacterial Community Convergence through Fertilizer Production: Storage, Pasteurization, and Struvite Precipitation by Rebecca H. Lahr (3217476)

“…Illumina 16S rRNA gene sequencing revealed a complex community of bacteria in fresh urine that differed across collection events. …”

DataSheet_1_Ten years of coverage of trophy hunting in UK newspapers.docx by Nikita Yeomans (14213501)

“…Pro-trophy hunting articles were very uncommon overall (3.5%). Articles that described the complexity of trophy hunting decreased following Cecil and were most common in pre-Cecil broadsheets (35.7%, dropping to 30.6%) and rarest in post-Cecil tabloids (3.1%). …”

Effects of UA on NOX 4 expression. by Daniela Verzola (675393)

“…<p>(A) NOX 4 expression was evaluated by real time-PCR at time 0 and 5 hours after 12 mg/dl UA incubation. …”

An EGFR tyrosine kinase inhibitor (Tyrphostin AG1478) blocks the effect of EGFL7 on EGFR phosphorylation, AKT phosphorylation, and cell motility. by Bai-Hua Luo (580269)

“…E-cadherin protein expression levels increased in BGC823 and MKN28-EGFL7 cells after Tyrphostin AG1478 treatment, while expression levels of the mesenchymal marker proteins vimentin and Snail decreased. pEGFR and pAKT expression levels were significantly lower in BGC823 and MKN28-EGFL7 cells treated with Tyrphostin AG1478 than in BGC823 and MKN28-EGFL7 cells treated with 0.25% DMSO. …”

SM22 regulates the expression of injury-induced NIK expression and inflammation <i>in vivo</i>. by Xiaohua Dai (459107)

“…<i>Sm22</i>^+/+ mice (n = 6); <i>Sm22</i>^-/- mice (n = 5). (C) The immunohistochemistry assays show decreased expression of NIK and VCAM1 in carotids of <i>Sm22</i>^-/- mice treated with SM22-GFP adenovirus (Ad-SM22) or its control GFP adenovirus (Ad-GFP) for two weeks after carotid ligation. …”

Crosstalk of daf-11/pkg-1/pde signaling in <i>C. elegans</i> analyzed by qRT-PCR and HPLC-MS/MS analysis of cGMP. by Ulrike Beckert (450918)

“…<i>Vice versa</i>, pde- deletion mutants showed reduced <i>pde-1</i> and <i>pde-5</i> gene expression connected with decreased daf-11 expression levels pointing to a direct dependency of <i>daf-11</i> and <i>pde-1</i> and <i>pde-5</i> gene expression in both directions. …”

<i>ΔmiR-125</i> mutant aging phenotypes are suppressed by loss of <i>chinmo</i>. by Geetanjali Chawla (2935899)

“…Reduced dosage of <i>chinmo</i> in <i>ΔmiR-125</i> mutants decreased the vacuole count (Two tailed t-test, mean ± S.D n = 5). …”

The synthetic lethality of the <i>erd1</i>Δ mutation with the Neo1p-depleted <i>cfs1</i>Δ mutation is not caused by reduced levels of cytoplasmic Pi. by Mamoru Miyasaka (9187916)

“…Cells were grown and spotted, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0236520#pone.0236520.g001" target="_blank">Fig 1B</a>, in YPGA (galactose) or YPDA (glucose) medium with either 20 mM Pi or 50 mM Pi and then incubated at 30°C for 1.5 d. …”