Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Reverse transcription-polymerase chain reaction analysis showing a strong decrease in clusterin RNA after treatment with antisense oligodeoxynucleotides to clusterin (ODNclu) in th... by Maximino Redondo (87169)

Ciliated prostate cancer and stromal cells have decreased axoneme lengths. by Nadia B. Hassounah (429199)

NB5-2 lineage in gnathal segments. by Christof Rickert (4836519)

HAART decreases Viral Load and increases CD4 counts and percentages. by Pietro Presicce (144163)

Osteoblast number is decreased in <i>Hdac3</i>-CKO mice. by David F. Razidlo (230381)

Decreases in oxygen induced Antxr1 transcription and expression at the cell surface. by N. J. Andersen (846668)

Blocking C5L2 decreased C5a-primed neutrophils for ANCA-induced degranulation. by Jian Hao (160736)

PKRA7 decreases subcutaneous pancreatic cancer xenograft tumor growth. by Valerie F. Curtis (276433)

Notch activity in skin cells is decreased in NAS mice and in response to γ-secretase inhibition (10 µM), and is increased in response to Jagged peptide treatment (15 µM). by Srinivasulu Chigurupati (81371)

NB5-3 lineage in gnathal segments. by Christof Rickert (4836519)

Mitochondrial superoxide increases the lifespan of worms with a detrimental level of cytoplasmic superoxide. by Claire E. Schaar (691681)

“…<p>To further test the extent to which superoxide has different effects on lifespan depending on which subcellular compartment it is in, mitochondrial superoxide levels were increased through treatment with 0.1 mM paraquat. <b>A,B</b>. Despite the fact that <i>clk-1;sod-1</i> and <i>clk-1;sod-5</i> worms have decreased lifespan compared to <i>clk-1</i> worms resulting from elevated cytoplasmic superoxde levels, both double mutants showed increased lifespan when treated with paraquat. …”

Ang 1–7 decreased Ang II-stimulated ER stress. by Dharmani Murugan (841819)

Rash presentation of marmosets intravenously exposed to decreasing doses of monkeypox virus. by Eric M. Mucker (146111)

“…<p>Notice the rash becomes more focal in nature as the dose is decreased: 2.4 x 10⁷ PFU, A, 9.5 x 10⁵ PFU, B, 7.8 x 10⁴ PFU, C, 5.0 x 10³ PFU, D, 510 PFU, E, and 48 PFU.…”

The estrogen receptor-α agonist PPT decreases cardiac myofilament activation. by Justyna Kulpa (313372)

“…<p>Myocardium was treated with the estrogen receptor-α agonist PPT (100 nM) for 1 (A) (N = 9), 2.5 (B) (N = 9), or 5 min (C) (N = 22). …”

Decreased proliferation in the primitive streak occurs coincident with Oct4 depletion. by Brian DeVeale (174713)

Inhibition of AhR signaling decreases growth of prostate cancer cells. by Oliver Richmond (585233)

Down-regulation of Hiwi decreases DNA-methylation and limits tumorigenic growth. by Sara Siddiqi (177728)

“…Error bars represent standard error. * = p<0.05 by Student's T Test (E) Untreated sh-Hiwi MFH cells or treated with 1 uM 5-azacytidine at 4 weeks in colony forming assay. 5-azacytidine treatment decreases colony formation capacity. …”

OPN-deficiency decreases inflammation, oxidative stress and fibrosis in adipose tissue. by Andoni Lancha (335824)

Infectivity of HIV-1 particles decreases upon treatment with MEK inhibitor. by Sheila Mansouri (324272)