Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

MCM-BP can decrease phosphorylation by DDK but is not a substrate. by Tin Nguyen (231591)

Activation of ERα with estrogen simultaneously increases PR expression and decreases Myc expression in endometrial cancer cells. by Tamar Kavlashvili (849072)

Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients by Bai-Wei Gu (740949)

“…Here we describe the production of iPS cells from DC patients with <i>DKC1 </i>mutations <i>Q31E</i>, <i>A353V </i>and <i>ΔL37</i>. …”

A decrease in cellular RNA increases the insolubility of TDP-43. by Shinnosuke Takagi (428655)

“…(C) Immunoblots of the immunoprecipitated protein with anti-V5 antibody or control IgG. (D) Reverse transcription-PCR (RT-PCR) of hNFL from immunoprecipitated RNA. …”

Repetitive stress induces a decrease in sound-evoked activity. by Ghattas Bisharat (20706928)

“…<p>(a) Left: noise-evoked activity rates at different noise intensities for chronically tracked PPys cells in baseline and repeated stress conditions (<i>N</i> = 5 mice, <i>n</i> = 285 neurons, mean ± SE). …”

Low glucose induces a decrease in LAMP2 expression. by Delphine Balmer (458897)

Percentage decrease in model output peak with the administration of exogenous estrogen/progesterone. by Brenda Lyn A. Gavina (15285185)

TITAN decreaser macroinvertebrate heatmap Heatmap of sensitive (i.e., <i>z-</i>) macroinvertebrate taxa (y-axis) to at least one of the five stressors, in decreasing order of numbe... by Brent J. Bellinger (21156150)

Decrease in GABA_A immunoreactivity in APP mice. by Ksenia V. Kastanenka (3692380)

“…(<b>D</b>) Voltage-sensitive dye traces showing a decrease in power of slow oscillations 60 minutes after topical application of 50 μM picrotoxin to a 4 month old wildtype mouse brain. …”

Atorvastatin decreases survival of sensitive but not resistant breast cancer cells. by Colin H. Beckwitt (2037196)

Leptin decreased cell aggregation, and increased cell migration and invasion. by Ameet K. Mishra (4047820)

In-hospital morality decreases with increasing absolute frequency of a procedure. by Bronislava Bashinskaya (306030)

C2GnT1 gene knock-down results in decreased binding of cells to E-selectin. by Catherine A. St. Hill (357388)

“…At a shear stress of 0.5 dynes/cm², significantly fewer C2GnT1 shRNA transduced cells accumulated on E-selectin than un-manipulated LS174T cells, *p = 0.04. …”

<i>Zip88E</i>^<i>Δ/Δ</i> larvae have decreased <i>MtnB</i>:<i>EYFP</i> expression. by Christopher D. Richards (4246669)

“…Variable <i>MtnB</i>:<i>EYFP</i> expression can be observed between individual flies, therefore an example of both ‘weak’ (top panel) and ‘strong’ (bottom panel) expression has been shown for each genotype and treatment. Decreased <i>MtnB</i>:<i>EYFP</i> expression is observed in <i>Zip88E</i>^<i>Δ/Δ</i> midguts (B, B’, E and E’) compared to control flies (A, A’, D and D’) on both food types. …”

MAF1 protein expression is significantly decreased in luminal, HER2-positive, and TNBC breast cancer subtypes. by Stephanie Cabarcas-Petroski (9631636)

Substrate translocation via Mep2^H194E induces a pH decrease. by Ana Sofia Brito (8463537)

Diabetic <i>TauT</i>-deficient mice showed kidney hypertrophy and decreased survival rate. by Xiaobin Han (608327)

PPP2R5C HepKD in <i>db/db</i> mouse liver improves insulin sensitivity, decreases hyperglycemia, but worsens the dyslipidemia. by Yong-Sheng Cheng (803758)

“…<p><b>(A)</b> Hyperglycemia in <i>db/db</i> mice is decreased upon hypatocyte-specific PPP2R5C knockdown with adeno-associated virus. …”

Supplementary Material for: TNFAIP2 Inhibits Early TNFa-Induced NF-κB Signaling and Decreases Survival in Septic Shock Patients by Thair S.A. (4152325)