Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody–drug conjugate (ADC). …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody–drug conjugate (ADC). …”

Decreased <i>CLE41</i> gene expression in <i>clv1-101 clv2-101 rpk</i>2-5 mutant and reduced nematode development on the <i>cle41</i> mutant. by Xiaoli Guo (45754)

AnxA5 results in a tendency to decrease the monocyte endothelium interaction in a flow model. by Robert Stöhr (3583700)

Critical role of miR-10b in B-Raf^V600E dependent anchorage independent growth and invasion of melanoma cells by Ila Datar (433874)

“…While expression of miR-10b enhances anchorage-independent growth of <i>B-Raf</i> wild-type melanoma cells, miR-10b silencing decreases <i>B-Raf</i>^<i>V600E</i> cancer cell invasion <i>in vitro</i>. …”

WDR81 is decreased in brains of patients with indicated neurodegenerative diseases compared with brains of control individuals. by Xuezhao Liu (413291)

MEK1/2 inhibition promotes invasive-opposing leading edge lamellipodial structures in 3-D by increasing localised Rac1 activity and decreasing localised RhoA activity. by Joseph H. R. Hetmanski (2656735)

Iota toxin increases type E adherence while decreases type A adherence. by Leandro M. Redondo (708975)

Percentage final biomass changes over 30 years (a) for scenarios 2 and 3 relative to scenario 1 (i.e. low fishing scenarios) (b) for scenarios 5 and 6 relative to scenario 4 (i.e. high fishing scenarios). for the nine functional groups that showed a decrease/increase of more than 8% in at least one of the scenarios. by Marie Savina (402195)

DeltaRRMean pattern for each condition, and AIC values for the five models considered. by Giulia Priolo (10146494)

Pupil Dilation pattern for each condition, and AIC values for the five models considered. by Giulia Priolo (10146494)

AZT decreases basal and SMM-stimulated mRNA and protein expression levels of MUC5AC in human airway epithelia. by Carla Maria P. Ribeiro (263581)

Sost and Sclerostin Expression are Decreased and Wnt Signaling is Increased in DMP1-caPTHR1 Transgenic Mice. by Charles A. O'Brien (271071)

Effect of noradrenaline (NA) alone (A) and NA with α1A- (B), α1B- (C), α1D- (D) and α1A,B,D (E)–adrenoreceptors (ARs) antagonists (a dose of 10⁻⁴ M) on the tension of co... by Barbara Jana (9110179)

Effect of noradrenaline (NA) alone (A) and NA with α1A- (B), α1B- (C), α1D- (D) and α1A,B,D (E)–adrenoreceptors (ARs) antagonists (a dose of 10⁻⁴ M) on the tension of co... by Barbara Jana (9110179)

Effect of noradrenaline (NA) alone (A) and NA with α1A- (B), α1B- (C), α1D- (D) and α1A,B,D (E)–adrenoreceptors (ARs) antagonists (a dose of 10⁻⁴ M) on the amplitude of... by Barbara Jana (9110179)

Effect of noradrenaline (NA) alone (A) and NA with α1A- (B), α1B- (C), α1D- (D) and α1A,B,D (E)–adrenoreceptors (ARs) antagonists (a dose of 10⁻⁴ M) on the frequency of... by Barbara Jana (9110179)