Image_1_Prescription trend and lactic acidosis in patients prescribed metformin before and after the revision of package insert for allowing metformin administration to patients wi... by Takashi Waki (17836445)

“…Introduction<p>This study was conducted to understand the impact of package insert (PI) revision in Japan on 18 June 2019 to allow metformin use for patients with moderately decreased kidney function (30 ≤ estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m²).…”

miR-144-3p and miR-486a-3p would be delivered to the liver via serum EVs in iFIRKO mice. by Yoshihiro Niitsu (14249456)

A higher mean amplitude or lower standard deviation of the EOD of the swimming fish facilitates estimation of beat frequency at the receptor level. by Na Yu (151735)

“…<p>(A) The height (solid line) of the peak of at the beat frequency, , and the width (dashed line) of this peak at the coherence value of 0.15 increase and slightly decrease, respectively, with (with fixed  = 0.1). …”

DataSheet_1_De Novo Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery.docx by Hong Chang Tan (9267627)

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis by Yuyan Xiong (658002)

“…Using human nonsenescent “young” and replicative senescent endothelial cells as well as <i>Apolipoprotein E</i>-deficient (<i>apoe</i>^−/−<i>Arg2</i>^+/+) and <i>Arg2</i>-deficient <i>apoe</i>^−/− (<i>apoe</i>^−/−<i>arg2</i>^−/−) mice fed a high-fat diet for 10 wk as the atherosclerotic animal model, we show here that overexpression of ARG2 in the young cells suppresses endothelial autophagy with concomitant enhanced expression of RICTOR, the essential component of the MTORC2 complex, leading to activation of the AKT-MTORC1-RPS6KB1/S6K1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1) cascade and inhibition of PRKAA/AMPK (protein kinase, AMP-activated, α catalytic subunit). …”

ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency by Philippe Joly (3161052)

“…Finally, these findings support a larger scale screening for HERPUD1 R50H and HFE H63D variants in the sub-group of 1ATD patients developing significant chronic hepatic injuries (hepatomegaly, chronic cholestasis, elevated liver enzymes) and at risk developing liver cirrhosis.…”

Vpr downregulated Mfn2 expression via VprBP-DDB1-CUL4A ubiquitin ligase complex. by Chih-Yang Huang (54970)

“…The ubiquitinated Mfn2 was detected in VprBP^KD, DDB1^KD, CUL4A^KD cells. Moreover, Vpr infection did not decrease Mfn2 expression in VprBP^KD, DDB1^KD, CUL4A^KD cells. * indicates the ubiquitinated Mfn2. …”

The pathophysiological relevance of Rab26 to diabetes mellitus. by Ruijuan Zhuang (3938915)

“…<p>(A) Fresh mouse islets were isolated and cultured in 1640 medium containing 10% FBS. …”

Selected metabolites of clinical interest. by Molly A. Bechtold (18794251)

Schematic of fixture. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Experimentation plan. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Experimental details. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Dimensions of FSW Tool. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Initial placements distributions, conditional on field. by Sergey V. Popov (6719075)

Fabricated Fixture with labelled view. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Dog-bone specimens after tensile testing. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Dog-bone specimens before tensile testing. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Experimental run of FSW on CNC milling machine. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Parallel testing of (a) cell vitality with MTT- and (b) membrane disruption with the LDH-assay at different time points (2 min, 15 min, 30 min, 2 h, 4 h, 24 h) and concentrations (... by Lars Steinstraesser (20161)

“…<p>The membrane integrity of the cells after incubation with [D]-K₃H₃L₉ at the LD₅₀ in 2 and 4 multiples showed a parabolic curve progression with over hundred percent LDH release after 24 h. …”

Change in estimated glomerular filtration rate (eGFR) in patients with normal-range proteinuria during 36 months of follow-up (n = 352). by Soichiro Iimori (4775169)

“…<p>eGFR levels of stage G2 and G3a chronic kidney disease (CKD) patients significantly decreased, whereas those of patients with a stage more advanced than G3b did not decrease during 36 months of follow-up.…”