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HRMECs treated with 3-Deazaneplanocin A (DZNep) chemical inhibitor demonstrated increased miR-200b and decreased VEGF expression.
Published 2015“…[NG = 5mM D-glucose, HG = 25mM D-glucose, NG+DMSO = 5mM D-glucose + 0.05% DMSO, HG+DMSO = 25mM D-glucose + 0.05% DMSO, NG+DZNEP = 5mM D-glucose + 5μM DZNep, HG+DZNEP = 25mM + 5μM DZNep; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to β-actin for VEGF and U6 for miR-200b, expressed as a fold change of NG].</p>…”
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UNC-62 RNAi decreases expression of collagen genes and increases expression of intestinal genes.
Published 2013“…The histogram indicates the distribution of genes by average fold-change upon <i>unc-62</i> RNAi. For 1699 genes with intestine-enriched expression <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-McGhee1" target="_blank">[23]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Pauli1" target="_blank">[33]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Spencer1" target="_blank">[34]</a> as well as the subset of 291 genes that also decrease expression with age <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Budovskaya1" target="_blank">[10]</a>, we determined the average mean-centered fold-change from triplicate RNA-seq experiments of <i>unc-62</i> RNAi as compared to controls. …”
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ABCA1 is expression in FLS and glyburide decreased the effect of rhPLTP on FLS proliferation.
Published 2018“…<p><b>(A)</b> Analysis of ABCA1 at the cell surface was performed by flow cytometry in FLS from 9 RA donors and 4 OA donors. …”
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Loss of ATXN3 is associated with decreased levels of HDAC3 and NCoR in MEFs.
Published 2018“…<p>(A) Western blot analysis of HDAC3, NCoR, PCAF, HDAC6, p300, ATXN3 and GAPDH in lysates from WT and <i>Atxn3</i>-KO MEFs. …”
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MiR-129-5p levels were decreased in mouse depression models.
Published 2025“…</b> Relative expression of miR-129-5p in the CTX, HIP, and HB regions of saline and LPS treated group. (n = 3 - 10 mice per group; Data are presented as the mean ± standard error; *, **, ***, and **** indicate significance at p < 0.05, p < 0.01, p < 0.001, and p < 0.0001, respectively.).…”
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Marimastat decreases hepatic stellate cell (HSC) activation, but increases recruitment of inflammatory cells.
Published 2013“…<p>Chronic carbon tetrachloride (CCl4) administration in animals treated with Marimastat resulted in a decreased activation of HSCs, as identified by alpha-smooth muscle actin (α-SMA) staining (A). …”
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