Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”

Flow chart of the study procedures. by Kazuhiko Ikeuchi (9234268)

“…In the multivariable analysis, higher age (predicted monthly RPR relative change on the log2 scale 0.23/10 years [95% confidence interval [CI], 0.090–0.37]), history of syphilis (0.36 [95% CI, 0.07–0.65]), and a lower ratio of RPR at treatment initiation/diagnosis (−0.52/every 10-fold increase [95% CI, −0.81 to −0.22]) were associated with a slower RPR decrease after treatment.…”

LOH resulting in 189R/R produces a strong decrease in drug susceptibility. by Pétra Vande Zande (17628246)

CX treatment leads to decreased perfusion and increased leakage after VEGF-A induced angiogenesis. by Mattias Kalén (224600)

Coupled negative feedback decreases the overall LG. by Rong Gao (476219)

The decrease in c-Myc protein levels in A549 cells was primarily due to proteasomal degradation. by Qin Li (36669)

COG annotation of differentially abundant proteins of three genotypes of <i>Lolium perenne</i> (fold increase>1.5, fold decrease<0.5, <i>P</i> < 0.05). by Fatemeh Raeisi Vanani (8991491)

Elevated serum IgA, decreased stool IgA, and decreased IgA coating of fecal bacteria in pIgR KO mice. by Kristina J. Betz (5329541)

“…(D) pIgR KO mice showed a 3-fold reduction in the percentage of stool bacteria coated with IgA (<i>P</i><0.0001, Mann-Whitney).…”

<i>eIF2A</i> overexpression decreases the cell wall protein levels. by Laura Meyer (4033793)

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). …”

Genes whose expression was decreased in RASMC subjected to Na⁺,K⁺-ATPase inhibition. by Svetlana V. Koltsova (321381)

“…Listed are assigned genes whose expression was decreased in K⁺-free medium by more than 3-fold and was different by less than 2-fold in the presence of ouabain compared to K⁺-free medium. …”

Si-Doped Fe Catalyst for Ammonia Synthesis at Dramatically Decreased Pressures and Temperatures by Qi An (331241)

“…Then we derived the full reaction path of the HB process for the Si doped Fe-bcc(111) from QM simulations, which we combined with kinetic Monte Carlo (kMC) simulations to predict a ∼13-fold increase in turnover frequency (TOF) under typical extreme HB conditions (200 atm reactant pressure and 500 °C) and a ∼43-fold increase in TOF under ideal HB conditions (20 atm reactant pressure and 400 °C) for the Si-doped Fe catalyst, in comparison to pure Fe catalyst. …”

Si-Doped Fe Catalyst for Ammonia Synthesis at Dramatically Decreased Pressures and Temperatures by Qi An (331241)

“…Then we derived the full reaction path of the HB process for the Si doped Fe-bcc(111) from QM simulations, which we combined with kinetic Monte Carlo (kMC) simulations to predict a ∼13-fold increase in turnover frequency (TOF) under typical extreme HB conditions (200 atm reactant pressure and 500 °C) and a ∼43-fold increase in TOF under ideal HB conditions (20 atm reactant pressure and 400 °C) for the Si-doped Fe catalyst, in comparison to pure Fe catalyst. …”

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

Exon number as a predictor of gene expression decrease. by Sarah W. Keenan (765990)

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase‑1 by Fei Ye (339913)

“…The mutations of N1248A and R1279D, which did not affect interactions between DNMT1 and substrates or cofactors, allosterically reduced enzymatic activities <i>in vitro</i> by decreasing <i>k</i>_cat/<i>K</i>_m for AdoMet. …”

Comparison of the decrease rate of IP-10 and VEGF in TB+HIV by Catherine Riou (164842)

Nuclear proteins increased or decreased in amount >2 fold during DENV-2 infection. by Han-Chen Chiu (542985)

Cytoplasmic proteins increased or decreased in amount >2 fold during DENV-2 infection. by Han-Chen Chiu (542985)