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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Published 2024“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”
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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Published 2024“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”
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Genes whose expression was decreased in RASMC subjected to Na<sup>+</sup>,K<sup>+</sup>-ATPase inhibition.
Published 2014“…Listed are assigned genes whose expression was decreased in K<sup>+</sup>-free medium by more than 3-fold and was different by less than 2-fold in the presence of ouabain compared to K<sup>+</sup>-free medium. …”
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Decrease in Vitamin D Status in the Greenlandic Adult Population from 1987–2010
Published 2014“…</p><p>Conclusion</p><p>We identified a remarkable decrease in vitamin D status from 1987 to 2005–2010 and a presently low vitamin D status among Inuit in Greenland. …”
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HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity
Published 2019Subjects: -
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In the absence of chloride, two-fold decrease in [Na<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by −28 mV at both low and high glutamate concentrations.
Published 2015“…Arrows show amplitudes and directions of E<sub>rev</sub> shifts associated with decrease in [Na<sup>+</sup>]<sub>e</sub>. <b>(D)</b> Average E<sub>rev</sub> shifts at [Glu<sup>-</sup>]<sub>e</sub> geometric means of 37.5 and 600 μM are approximately equal when [Na<sup>+</sup>]<sub>e</sub> was decreased from 102 to 51 mM. …”
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