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Patients with NDO have decreased BKα subunit mRNA expression in DSM.
Published 2013“…<p>qPCR analyses showing 15.8-fold, 1.1-fold, and 1.6-fold decreases in BKα (<b>A</b>), BKβ1 (<b>B</b>), and BKβ4 subunits (<b>C</b>) mRNA expression in NDO DSM tissue (n = 3, N = 3) compared to controls (n = 7, N = 7; **P<0.01). …”
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A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes
Published 2010“…<em>PPARA</em> A for both ERR-α and -γ (3.1 vs.1.9-fold; P<0.05). …”
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UNC-62 RNAi decreases expression of collagen genes and increases expression of intestinal genes.
Published 2013“…The histogram indicates the distribution of genes by average fold-change upon <i>unc-62</i> RNAi. For 1699 genes with intestine-enriched expression <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-McGhee1" target="_blank">[23]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Pauli1" target="_blank">[33]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Spencer1" target="_blank">[34]</a> as well as the subset of 291 genes that also decrease expression with age <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Budovskaya1" target="_blank">[10]</a>, we determined the average mean-centered fold-change from triplicate RNA-seq experiments of <i>unc-62</i> RNAi as compared to controls. …”
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HRMECs treated with 3-Deazaneplanocin A (DZNep) chemical inhibitor demonstrated increased miR-200b and decreased VEGF expression.
Published 2015“…[NG = 5mM D-glucose, HG = 25mM D-glucose, NG+DMSO = 5mM D-glucose + 0.05% DMSO, HG+DMSO = 25mM D-glucose + 0.05% DMSO, NG+DZNEP = 5mM D-glucose + 5μM DZNep, HG+DZNEP = 25mM + 5μM DZNep; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to β-actin for VEGF and U6 for miR-200b, expressed as a fold change of NG].…”
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SPRY4 transcript decreases for IDCs compared to normal tissue in the TCGA Breast dataset.
Published 2021“…<p>Data mining of the TCGA Breast dataset revealed a 1.53-fold decrease in SPRY4 mRNA expression in IDCs (n = 389) compared to non-cancerous breast tissue (n = 61). …”
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DTG mice have significantly decreased troponin I phosphorylation and Serca2 expression.
Published 2013“…<p>(A) Representative Western blots depicting no changes in the expression of phosphorylated protein kinase A (P-PKA) and decreased expression of phosphorylated troponin I (P-TnI) and Serca2. ß-tubulin was used as a loading control. …”
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ABCA1 is expression in FLS and glyburide decreased the effect of rhPLTP on FLS proliferation.
Published 2018“…Results are presented as fold increase vs unstimulated conditions (no inhibitors and RPMI only) (n = 5, p<0.05 (one-tailed p value), Wilcoxon paired test).…”
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