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point decrease » point increase (Expand Search)
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1001
Reversible Activation of a Cell-Penetrating Peptide in a Membrane Environment
Published 2015“…Below pH 6, the sequence folds into a helix and can disrupt membranes. In this study, we show that the lipid bilayer radius-of-curvature has a negligible effect on GALA-induced leakage kinetics and that GALA remains pH responsive after inserting into a lipid membrane. …”
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1002
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1003
Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen.
Published 2023“…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …”
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1004
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1005
Hsc70 prevented Rab1A degradation.
Published 2014“…(B) Hsc70 knockdown decreased the level of Rab1A protein under stress conditions. …”
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1006
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1007
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1008
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1009
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1010
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1011
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1012
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1013
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1014
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1015
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1016
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1017
Increase of proliferating progenitor cells and decrease of terminally differentiated granule neurons in the immature dentate gyrus of <i>PC3/Tis21</i>-null mice at P14.
Published 2009“…(<b>B</b>, <b>C</b>) The same significant increase is observed for the number of dividing progenitor cells, identified either as (<b>B</b>) Ki67-positive, or as (<b>C</b>) Ki67/Sox2-positive cells (1.5-fold). (<b>D</b>) The newly generated neurons (1 hour pulse of BrdU) decreased sharply (20%). …”
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1018
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1019
Pharmacodynamic Profile of CCX168 in Healthy Human Volunteers.
Published 2016“…CD11b upregulation was diminished in both blood samples from CCX168 subjects with a 10-fold decrease in C5a potency exhibited in the 12-hour samples.…”
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1020