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Binding of <i>PC3/Tis21</i> to the <i>Id3</i> promoter and corresponding decrease of <i>Id3</i> mRNA.
Published 2009“…(<b>B</b>) ChIP analysis of <i>PC3</i> binding to the <i>Id3</i> promoter in PC12 cells, treated as shown in (<b>A</b>). A scheme above the graph describes the <i>Id3</i> gene and the promoter region analyzed, 700 nt 5′ to the transcription start. …”
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423
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Loss of virulence in the SIN kinase mutants is characterized by decreased fungal burden and host response to infection.
Published 2021“…<p><b>A)</b> Analysis of fungal burden by qPCR at day +4 post inoculation. …”
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425
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427
Influence of Acidic pH on Hydrogen and Acetate Production by an Electrosynthetic Microbiome
Published 2014“…Cyclic voltammetry revealed a 250 mV decrease in hydrogen overpotential and a maximum current density of 12.2 mA/cm<sup>2</sup> at −765 mV (0.065 mA/cm<sup>2</sup> sterile control at −800 mV) by the <i>Acetobacterium</i>-dominated community. …”
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428
Avertin®-induced decrease in basal particle transport speed (PTS) remains unaffected in WT mice in the presence of TASK-1 inhibitors and in TASK-1 KO mice.
Published 2016“…<p><b>(A)</b> Avertin® in the presence of anandamide did not decrease PTS significantly. …”
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429
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DHT increases whereas orchidectomy decreases the seminal vesicle weight in wild-type and SOD1-G93A mice.
Published 2013“…Conversely, orchidectomy decreased the seminal vesicle weight in both WT mice (28.4±13 mg, <i>p</i><0.0001) and SOD1 mice (20.8±3.5 mg, <i>p</i><0.0001) compared with control WT and SOD1 mice, respectively. …”
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434
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Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice
Published 2017“…MMP-2 and 9 activity levels in the infarcted myocardium were significantly lower in AIM<sup><b>‒/‒</b></sup> mice than in WT mice.</p><p>Conclusions</p><p>These findings suggest that AIM depletion decreases the levels of M1 macrophages, which are a potent source of MMP-2 and 9, in the infarcted myocardium in the acute phase after MI by promoting macrophage apoptosis, and leads to a decrease in the incidence of cardiac rupture and improvements in survival rates.…”
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436
The m<sup>6</sup>A peak of 3’UTR of TLR4 mRNA decreases significantly in METTL14-knockdown PK-15 cells.
Published 2024“…<p>(A) The m<sup>6</sup>A peak marked in green is decreased in the 3’UTR of TLR4, TLR6, MYD88, TRIF, and other 7 genes from m<sup>6</sup>A-seq data in METTL14-knockdown PK-15 cells infected with CSFV (MOI = 1). …”
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437
HRMECs treated with SUZ12 siRNA demonstrate increased miR-200b expression, decreased VEGF expression and decreased endothelial branching.
Published 2015“…However, transfection of SUZ12 siRNA significantly reduced endothelial branching compared to HG+control siRNA. [NG+control siRNA = 5mM D-glucose + 100nM control siRNA, HG+control siRNA = 25mM D-glucose + 100nM control siRNA, HG+EZH2 siRNA = 25mM D-glucose + 100nM EZH2 siRNA, HG+SUZ12 siRNA = 25mM + 100nM SUZ12 siRNA; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to U6 or β-actin and expressed as a fold change of NG+control siRNA].…”
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438
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Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors
Published 2017“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”