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Showing 19,281 - 19,300 results of 105,092 for search '(( a fold decrease ) OR ( 5 ((point decrease) OR (((a decrease) OR (mean decrease)))) ))', query time: 1.80s Refine Results
  1. 19281
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  2. 19282
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  3. 19283
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  4. 19284
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  5. 19285
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  6. 19286
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  7. 19287
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  8. 19288
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  9. 19289
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  10. 19290
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  11. 19291
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  12. 19292
    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

    Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 by Charlie Fehl (1945474)

    Published 2018
    “…The best analogs increased selectivity of CYP17A1 inhibition up to 84-fold compared with 6.6-fold for abiraterone. …”
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  13. 19293
    Immunohistochemical (IHC) staining of mitochondrial OXPHOS complexes I-V and VDAC in SH-SY5Y xenograft tumors.

    Immunohistochemical (IHC) staining of mitochondrial OXPHOS complexes I-V and VDAC in SH-SY5Y xenograft tumors. by Raphael Johannes Morscher (751235)

    Published 2015
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  14. 19294
    Effects of forced Elf5 expression on tumor growth and cell autonomous pro-tumorigenic traits.

    Effects of forced Elf5 expression on tumor growth and cell autonomous pro-tumorigenic traits. by David Gallego-Ortega (107516)

    Published 2016
    “…<p><b>Panel A</b>, PyMT mammary tumors showing heterogeneous expression of ELF5 visualized by EGFP expression. …”
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  15. 19295
    A Family of Binuclear Dysprosium(III) Radical Compounds with Magnetic Relaxation in ON and OFF States

    A Family of Binuclear Dysprosium(III) Radical Compounds with Magnetic Relaxation in ON and OFF States by Tian Han (1674109)

    Published 2012
    “…The adduct ([Dy­(hfac)<sub>3</sub>(PyNONIT)]<sub>2</sub>[Dy<sub>0.5</sub>(hfac)<sub>1.5</sub>(H<sub>2</sub>O)]<sub>2</sub>) (<b>3</b>) consists of two items, the dimer [Dy­(hfac)<sub>3</sub>(PyNONIT)]<sub>2</sub> and the monomer [Dy­(hfac)<sub>3</sub>(H<sub>2</sub>O)<sub>2</sub>], where the symmetry of Dy<sup>III</sup> ion in Dy<sub>2</sub>O<sub>2</sub> decreases to <i>D</i><sub>2<i>d</i></sub>, showing slow relaxation of the magnetization at lower temperature. …”
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  16. 19296
    Electrochemical, Computational, and Photophysical Characterization of New Luminescent Dirhenium–Pyridazine Complexes Containing Bridging OR or SR Anions

    Electrochemical, Computational, and Photophysical Characterization of New Luminescent Dirhenium–Pyridazine Complexes Containing Bridging OR or SR Anions by Alessio Raimondi (2108038)

    Published 2012
    “…A series of [Re<sub>2</sub>(μ-ER)<sub>2</sub>(CO)<sub>6</sub>(μ-pydz)] complexes have been synthesized (E = S, R = C<sub>6</sub>H<sub>5</sub>, <b>2</b>; E = O, R = C<sub>6</sub>F<sub>5</sub>, <b>3</b>; C<sub>6</sub>H<sub>5</sub>, <b>4</b>; CH<sub>3</sub>, and <b>5</b>; H, <b>6</b>), starting either from [Re­(CO)<sub>5</sub>O<sub>3</sub>SCF<sub>3</sub>] (for <b>2</b> and <b>4</b>), [Re<sub>2</sub>(μ-OR)<sub>3</sub>(CO)<sub>6</sub>]<sup>−</sup> (for <b>3</b> and <b>5</b>), or [Re<sub>4</sub>(μ<sub>3</sub>-OH)<sub>4</sub>(CO)<sub>12</sub>] (for <b>6</b>). …”
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  17. 19297
    Electrochemical, Computational, and Photophysical Characterization of New Luminescent Dirhenium–Pyridazine Complexes Containing Bridging OR or SR Anions

    Electrochemical, Computational, and Photophysical Characterization of New Luminescent Dirhenium–Pyridazine Complexes Containing Bridging OR or SR Anions by Alessio Raimondi (2108038)

    Published 2012
    “…A series of [Re<sub>2</sub>(μ-ER)<sub>2</sub>(CO)<sub>6</sub>(μ-pydz)] complexes have been synthesized (E = S, R = C<sub>6</sub>H<sub>5</sub>, <b>2</b>; E = O, R = C<sub>6</sub>F<sub>5</sub>, <b>3</b>; C<sub>6</sub>H<sub>5</sub>, <b>4</b>; CH<sub>3</sub>, and <b>5</b>; H, <b>6</b>), starting either from [Re­(CO)<sub>5</sub>O<sub>3</sub>SCF<sub>3</sub>] (for <b>2</b> and <b>4</b>), [Re<sub>2</sub>(μ-OR)<sub>3</sub>(CO)<sub>6</sub>]<sup>−</sup> (for <b>3</b> and <b>5</b>), or [Re<sub>4</sub>(μ<sub>3</sub>-OH)<sub>4</sub>(CO)<sub>12</sub>] (for <b>6</b>). …”
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  18. 19298
    Synthesis and Cyclic Voltammetric Studies of the Diiron Complexes ER<sub>2</sub>[(η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(L<sub>2</sub>)Me]<sub>2</sub> (E = C, Si, Ge, Sn; R = H, alkyl; L<sub>2</sub> = diphosphine) and (η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>)Fe(L<sub>2</sub>)ER<sub>2</sub>Fc (Fc = (η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>))

    Synthesis and Cyclic Voltammetric Studies of the Diiron Complexes ER<sub>2</sub>[(η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(L<sub>2</sub>)Me]<sub>2</sub> (E = C, Si, Ge, Sn; R =... by Mukesh Kumar (132604)

    Published 2008
    “…Cyclic voltammetric studies on ER<sub>2</sub>[(η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(L<sub>2</sub>)Me]<sub>2</sub> (L<sub>2</sub> = dppe; ER<sub>2</sub><i></i> = CH<sub>2</sub> (<b>1a</b>), SiMe<sub><i>2</i></sub> (<b>2a</b>), GeMe<sub>2</sub> (<b>3a</b>), SnMe<sub>2</sub> (<b>4a</b>)) revealed two well-resolved reversible waves (<sup>1</sup><i>E</i><sub>1/2</sub> = −0.33 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.20 V (for <b>1a</b>); <sup>1</sup><i>E</i><sub>1/2</sub> = −0.35 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.21 V (for<i></i> <b>2a</b>); <sup>1</sup><i>E</i><sub>1/2</sub> = −0.36 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.23 V (for <b>3a</b>); <sup>1</sup><i>E</i><sub>1/2</sub> = −0.36 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.22 V (for <b>4a</b>)) in CH<sub>2</sub>Cl<sub>2</sub>, suggesting electronic communication between two iron centers, which is seen for the first time in this family of organometallic complexes. …”
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  19. 19299
    Synthesis and Cyclic Voltammetric Studies of the Diiron Complexes ER<sub>2</sub>[(η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(L<sub>2</sub>)Me]<sub>2</sub> (E = C, Si, Ge, Sn; R = H, alkyl; L<sub>2</sub> = diphosphine) and (η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>)Fe(L<sub>2</sub>)ER<sub>2</sub>Fc (Fc = (η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>))

    Synthesis and Cyclic Voltammetric Studies of the Diiron Complexes ER<sub>2</sub>[(η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(L<sub>2</sub>)Me]<sub>2</sub> (E = C, Si, Ge, Sn; R =... by Mukesh Kumar (132604)

    Published 2008
    “…Cyclic voltammetric studies on ER<sub>2</sub>[(η<sup>5</sup>-C<sub>5</sub>H<sub>4</sub>)Fe(L<sub>2</sub>)Me]<sub>2</sub> (L<sub>2</sub> = dppe; ER<sub>2</sub><i></i> = CH<sub>2</sub> (<b>1a</b>), SiMe<sub><i>2</i></sub> (<b>2a</b>), GeMe<sub>2</sub> (<b>3a</b>), SnMe<sub>2</sub> (<b>4a</b>)) revealed two well-resolved reversible waves (<sup>1</sup><i>E</i><sub>1/2</sub> = −0.33 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.20 V (for <b>1a</b>); <sup>1</sup><i>E</i><sub>1/2</sub> = −0.35 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.21 V (for<i></i> <b>2a</b>); <sup>1</sup><i>E</i><sub>1/2</sub> = −0.36 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.23 V (for <b>3a</b>); <sup>1</sup><i>E</i><sub>1/2</sub> = −0.36 V, <sup>2</sup><i>E</i><sub>1/2</sub> = −0.22 V (for <b>4a</b>)) in CH<sub>2</sub>Cl<sub>2</sub>, suggesting electronic communication between two iron centers, which is seen for the first time in this family of organometallic complexes. …”
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  20. 19300
    Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation

    Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation by Christian Berrios (127454)

    Published 2016
    “…While MYC was required for MCT1 induction, MCPyV-induced MCT1 levels decreased following knockdown of the NF-κB subunit RelA, supporting a synergistic activity between MCPyV and MYC in regulating MCT1 levels. …”
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