DnaK inhibits protein synthesis in vivo and in vitro. by Carissa Chan (18310140)

DnaK’s ATPase activity is stimulated by ribosomes and required to reduce protein synthesis. by Carissa Chan (18310140)

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Raw data 1–5. by Fateme Khorramroo (18086501)

DnaK associates with intact ribosomes and not with dismantled ribosomes. by Carissa Chan (18310140)

Trigger factor hinders DnaK-mediated reduction of protein synthesis. by Carissa Chan (18310140)

Preparations of DnaK protein are pure. by Carissa Chan (18310140)

DnaK does not refold heat-denatured luciferase when incubated in the presence of ribosomes. by Carissa Chan (18310140)

<i>Slc13a5</i>^<i>-/-</i> mice had decreased enamel volume as measured with μCT. by Armando R. Irizarry (422739)

Reduced follicles, decreased ovulation and decreased fertilization of female Meox-2-cre/Separase S1121A mutant mice. by Juan Xu (225010)

Graphs showing the mean maximum temperature increase at the position with the highest mean temperature increase (A) and the mean temperature increase across all probes (B) for each... by Marsel Ganeyev (21453399)

Table S1 - Human <i>NR5A1</i>/SF-1 Mutations Show Decreased Activity on BDNF (Brain-Derived Neurotrophic Factor), an Important Regulator of Energy Balance: Testing Impact of Novel SF-1 Mutations Beyond Steroidogenesis by Jana Malikova (615672)

Subjects:

Decrease of viral load and ALT at different time points under treatment according to NS5A-inhibitors and interferon administration. by Valeria Cento (103603)

Flowchart displaying the steps of the present study. by Jingtian Yang (11966345)

A DNA-PKcs-specific inhibitor decreases HBoV1 infection of HAE-ALI. by Xuefeng Deng (138723)

Illustrations of the SeqFold2D network and the Stralign dataset. by Xiangyun Qiu (316117)

Data processing and analysis steps. by Alexandra V. Kulinkina (5335058)

“…We derived environmental variables from fine-resolution RS data (Landsat 8) and examined a variable distance radius (1–5 km) for aggregating these variables around point-prevalence locations in a non-parametric random forest modeling approach. …”

LuxR G37V has decreased DNA-binding activity. by Chelsea A. Simpson (9579303)

Data_Sheet_1_Decrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures.PDF by Laura Gagliano (14378124)

“…Each standard deviation decrease in sleep efficiency and increase in wake after sleep onset was respectively associated with a 1.25-fold (95 % CI: 1.05 to 1.42, p < 0.05) and 1.49-fold (95 % CI: 1.17 to 1.92, p < 0.01) increased odds of seizure occurrence the following day. …”