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marked decrease » marked increase (Expand Search)
large decrease » larger decrease (Expand Search), large increases (Expand Search), large degree (Expand Search)
i marked » _ marked (Expand Search), _ market (Expand Search), _ marker (Expand Search)
via mean » via metal (Expand Search), a mean (Expand Search), i mean (Expand Search)
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Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8.
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Eggs jointly coordinate a caspase-1 and caspase-8 dependent pyroptotic cell death.
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related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs.
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ROS, K<sup>+</sup> efflux and cathepsin B are required for NLRP3 activation.
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The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses.
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<b>The loss of insulin-positive cell clusters precedes the decrease of islet frequency and beta cell area in type 1 diabetes</b>
Published 2025“…Insulin-positive (INS+) single cells (≤10µm), cell clusters (>10 to <35µm), small- and medium-sized islets (35-100µm and 100-200µm) were significantly lost at type 1 diabetes onset, while large INS+ islets (>200µm) were preserved. Moreover, changes in endocrine composition also occurred in mAAb+ donors, including a significant decrease in the INS+ islet fraction. …”
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