Data Sheet 1_Citywide community-based colorectal cancer screening in urban Shanghai: age and sex variations in risk mitigation from 1973 to 2020.docx by Mengyin Wu (8778272)

“…However, elderly mortality decreased significantly (APC: 1.47% to −3.03%, P < 0.001).…”

smFISH probe sequences used in this study. by Grace E. Johnson (21376787)

“…To define mechanisms underlying biofilm developmental transitions, we establish a single-molecule fluorescence in situ hybridization (smFISH) approach that enables accurate quantitation of spatiotemporal gene-expression patterns in biofilms at cell-scale resolution. smFISH analyses of <i>V. cholerae</i> biofilm regulatory and structural genes demonstrate that, as biofilms mature, overall matrix gene expression decreases, and simultaneously, a pattern emerges in which matrix gene expression becomes largely confined to peripheral biofilm cells. …”

Strains used in this study. by Grace E. Johnson (21376787)

“…To define mechanisms underlying biofilm developmental transitions, we establish a single-molecule fluorescence in situ hybridization (smFISH) approach that enables accurate quantitation of spatiotemporal gene-expression patterns in biofilms at cell-scale resolution. smFISH analyses of <i>V. cholerae</i> biofilm regulatory and structural genes demonstrate that, as biofilms mature, overall matrix gene expression decreases, and simultaneously, a pattern emerges in which matrix gene expression becomes largely confined to peripheral biofilm cells. …”

Water-saving strategies in rice farming entail cascading effects in prey-predator interactions across ecosystem boundaries by Néstor Pérez-Méndez (7845404)

“…<i>Synthesis and applications</i><i>:</i> These results show that introducing multiple drainage periods in rice fields (i.e., AWD) indirectly hampers terrestrial spider reproduction through limiting the emergence of potential preys from the aquatic to terrestrial boundaries. MSD resulted in a more conciliatory strategy as it largely reduces methane emissions and does not affect predator-prey interactions, thus it should be prioritized over AWD to minimize environmental trade-offs. …”

Data Sheet 1_Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration.docx by Viola Niemann (22572638)

“…Critical pathomechanisms involve immune cell infiltration and degradation of the vascular extracellular matrix (ECM). Hyaluronan (HA), a major constituent of the ECM synthesized by three HA synthase isoenzymes (HAS1-3), plays a role in both processes. …”

Table 1_Integrated multi-omics analysis reveals the mechanisms of naringin in ameliorating high-fat diet-induced metabolic dysfunction-associated steatotic liver disease.doc by Wenping Sun (1465360)

“…However, its underlying mechanisms remain largely elusive.</p>Methods<p>In this study, we investigated the efficacy and underlying mechanisms of Nar in a mouse model of high-fat diet (HFD)-induced MASLD using integrated analyses of network pharmacology, molecular docking, hepatic lipidomics, and gut microbiota.…”

Deficiency of the UBE2C/F264 Axis Underlies Intrinsic Radioresistance in Cervical Carcinoma by Maowei Ni (15397932)

“…Intrinsic radiotherapy resistance remains a persistent challenge to the treatment of cervical cancer (CC), as the underlying mechanisms remain largely elusive. …”

Data Sheet 1_Trifolin inhibits the calcium-driven contraction pathway in vascular smooth muscle.pdf by Renfeng Li (126284)

“…<p>Trifolin, a bioactive component of the Qingda granule, has demonstrated significant antihypertensive potential; however, its precise mechanisms of action remain largely unknown. …”

Deficiency of the UBE2C/F264 Axis Underlies Intrinsic Radioresistance in Cervical Carcinoma by Maowei Ni (15397932)

“…Intrinsic radiotherapy resistance remains a persistent challenge to the treatment of cervical cancer (CC), as the underlying mechanisms remain largely elusive. …”

Deficiency of the UBE2C/F264 Axis Underlies Intrinsic Radioresistance in Cervical Carcinoma by Maowei Ni (15397932)

“…Intrinsic radiotherapy resistance remains a persistent challenge to the treatment of cervical cancer (CC), as the underlying mechanisms remain largely elusive. …”

Data Sheet 1_Sodium-glucose cotransporter 2 inhibitors—but not insulin—enhance renal branched-chain amino acid catabolism.docx by Moeko Sakamoto (22578098)

“…Aims/hypothesis<p>Sodium–glucose cotransporter 2 inhibitors (SGLT2i) confer cardio-renal protection, and recent work implicates enhanced branched-chain amino acid (BCAA) catabolism as a potential mechanism in the heart. Whether SGLT2i also promotes renal BCAA catabolism is largely unknown. …”

Supplementary file 1_Effects of different urban vegetation cover and green space types on soil greenhouse gas emissions and carbon sequestration.docx by Ruisha Zhang (21287978)

“…<p>The development of urbanization has led to the creation of various types of green spaces, which have a direct influence on vegetation types and soil management, This, in turn, results in differences in soil carbon sequestration capacities. …”

Image 1_Human papillomavirus infection affects the immune microenvironment and antigen presentation in penile cancer.tif by Sulayne Janayna Araujo Guimarães (19866909)

“…<p>Penile squamous cell carcinoma (PSCC) is a largely neglected condition, predominantly affecting underdeveloped regions, and is associated with risk factors such as low socioeconomic status, phimosis, and human papillomavirus (HPV) infection. …”

Table 1_Fertility anxiety vs. anti-fertility anxiety: exploring Chinese women’s conflicting attitudes toward childbearing through social media.docx by Weiwei Li (364036)

“…Anti-fertility anxiety is more rooted in micro-level expression, emphasizing reproductive autonomy and identification with motherhood amid a broader feminist awakening. The emotional tendency of fertility anxiety is predominantly negative, with intensity decreasing from the macro to the meso and micro levels. …”

Supplementary file 2_Gut microbiome and serum metabolome alterations in osteosarcoma patients.xlsx by Chao Li (145513)

“…</p>Results<p>The gut microbial diversity decreased in osteosarcoma patients compared to healthy individuals. …”

Supplementary file 1_Gut microbiome and serum metabolome alterations in osteosarcoma patients.docx by Chao Li (145513)

“…</p>Results<p>The gut microbial diversity decreased in osteosarcoma patients compared to healthy individuals. …”

Dietary iron attenuates <i>Clostridioides difficile</i> infection via modulation of intestinal immune response and gut microbiota by Xiao Li (107004)

“…Host vulnerability to <i>C. difficile</i> infection (CDI) is largely affected by gut microbiota, which in turn is influenced by diet. …”

Supplementary file 1_Heavy metal pollution simplifies microbial networks and enhances modularity during tailings primary succession: divergent assembly dynamics for bacterial and f... by Min Li (12799)

“…Community assembly analysis further showed a shift toward deterministic processes in bacterial communities under high pollution, while fungal assembly remained largely stochastic. …”

Data Sheet 1_Characterization of lysine crotonylation-related lncRNAs for prognostic assessment and immune response in glioma.zip by Miaomiao Song (10755624)

“…Background<p>Glioma is a highly aggressive brain tumor with limited therapeutic options and poor prognosis. …”

Image 3_Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice.jpeg by Ling Kui (6108440)

“…Background<p>Atopic Dermatitis (AD), a chronic inflammatory skin disease characterized by pruritus, dryness, redness, edema, scratching, and lichenification, ranks as the leading cause of non-fatal skin disease burden globally. …”