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marked decrease » marked increase (Expand Search)
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Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8.
Published 2025Subjects: -
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Eggs jointly coordinate a caspase-1 and caspase-8 dependent pyroptotic cell death.
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related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs.
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ROS, K<sup>+</sup> efflux and cathepsin B are required for NLRP3 activation.
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The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses.
Published 2025Subjects: -
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MEDOC: A Fast, Scalable, and Mathematically Exact Algorithm for the Site-Specific Prediction of the Protonation Degree in Large Disordered Proteins
Published 2025“…To address this problem, we developed "multisite extent of deprotonation originating from context" (MEDOC) to determine the degree of protonation of a protein based on the local sequence context of each ionizable residue. …”
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Published 2025“…Following the overexpression of miRNA 221 in myocardium, there was a marked alleviation of myocardial injury and cardiomyocyte apoptosis and necrosis, significant enhancement of left ventricular systolic function, and marked decrease in the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), caspase 3 and Cyt C, as well as a significant decrease in total calcium levels in myocardium.…”
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