A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid by Chengzhi Chen (19567437)

“…Metabolomics revealed that P. goldsteinii increases 1,4-methylimidazoleacetic acid (MIAA), a metabolite linked to decreased body weight in animal models. …”

In superadditive networks, more enhancers decrease noise and fidelity. by Alvaro Fletcher (15675430)

Supplementary Materials for Genotypic and phenotypic spectrum and pathogenesis of WNT1 variants in a large cohort of patients with OI / osteoporosis by Jing Hu (14249099)

“…Due to its rarity, the clinical characteristics and pathogenic mechanism of <em>WNT1</em> mutations remain unclear. We aimed to explore the phenotypic and genotypic spectrum and treatment responses of a large cohort of patients with WNT1-related OI/OP and the molecular mechanisms of <em>WNT1 </em>variants. …”

Sodium levels (mg/100 g) in matched restaurant menu items in 2016 and 2020 by UK NSRI food categories with ≥ 10 items. by Caroline G. Middleton (22041479)

Waste gain due to taxation change (<i>τ</i> = 0.2 → <i>τ</i> = 0). by Jan Eeckhout (11767418)

Subjects:

Energy gain due to taxation change (<i>τ</i> = 0.2 → <i>τ</i> = 0). by Jan Eeckhout (11767418)

Subjects:

The transcriptional response of IECs to <i>C</i>. <i>albicans</i> infection is largely damage- and filamentation-independent. by Jakob L. Sprague (18087148)

Mechanical response of the isotropic vertex model at finite temperature as a function of T1 delay time. by Gonca Erdemci-Tandogan (10934221)

Performance on increasingly large data sets. by Kieran Elmes (11127506)

Spatial information of excitatory neurons in APP/PS1 mice are decreased in dCA1 and vCA1. by Udaysankar Chockanathan (18510288)

Supplementary Material for: Effects of White Matter Hyperintensities on 90-Day Functional Outcome after Large Vessel and Non-Large Vessel Stroke by Griessenauer C.J. (8965901)

“…<b><i>Material and Methods:</i></b> We reviewed acute ischemic stroke patients admitted between 2009 and 2017 at a large healthcare system in the USA. …”

Simulation of the average densities/concentrations of the variables for model (2)–(21) with ENZ, Sip-T, anti-PD-1 (<i>A</i>₁) and anti-CTLA-4 (<i>A</i>₄). by Nourridine Siewe (5081834)

Table_1_Activation of farnesoid X receptor suppresses ER stress and inflammation via the YY1/NCK1/PERK pathway in large yellow croaker (Larimichthys crocea).DOCX by Jianlong Du (9295559)

“…Further investigation showed that the TM-induced phosphorylation of PERK and EIF2α was inhibited by the overexpression of croaker FXR, and it was increased by FXR knockdown. Croaker NCK1 was then confirmed to be a regulator of PERK, and its expression in macrophages is increased by FXR overexpression and decreased by FXR knockdown. …”

Image_1_Evaluation of Live Bacterial Prophylactics to Decrease IncF Plasmid Transfer and Association With Intestinal Small RNAs.tif by Graham A. J. Redweik (5648027)

Table_1_Evaluation of Live Bacterial Prophylactics to Decrease IncF Plasmid Transfer and Association With Intestinal Small RNAs.docx by Graham A. J. Redweik (5648027)

Image_1_A large-scale forward genetic screen for maize mutants with altered lignocellulosic properties.tiff by Shaogan Wang (14727736)

“…Saccharification yield, i.e. the amount of lignocellulosic glucose (Glc) released by means of enzymatic hydrolysis, is increased in two of the mutants and decreased in the remaining six. …”

Table_1_A large-scale forward genetic screen for maize mutants with altered lignocellulosic properties.docx by Shaogan Wang (14727736)

“…Saccharification yield, i.e. the amount of lignocellulosic glucose (Glc) released by means of enzymatic hydrolysis, is increased in two of the mutants and decreased in the remaining six. …”

Decreased CNPase levels in the SG/RC in <i>Large</i>^{<i>myd/myd</i>} <i>mice</i>. by Shigefumi Morioka (8893511)

“…<p>Lysates were obtained from the spiral ganglion (SG)/Rosenthal’s canal (RC) of the P5-7 control and <i>Large</i>^{<i>myd/myd</i>} mice. CNPase immunoblotting showed decreased levels of CNPase in the <i>Large</i>^{<i>myd/myd</i>} mice. …”

Data_Sheet_1_Metabolic Changes in Scylla paramamosain During Adaptation to an Acute Decrease in Salinity.docx by Hongzhi Yao (11634571)

“…<p>The mud crab Scylla paramamosain is an important euryhaline mariculture species. However, acute decreases in salinity seriously impact its survival and can result in large production losses. …”

Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma by Hao Shi (158171)

“…</p> <p><b>Abbreviation</b>: 3-MA, 3-methyladenine; AL, autolysosome; AP, autophagosome; Baf-A1, bafilomycin A₁; BARA, β-α repeated autophagy specific domain; BH3, BCL2 homology 3 domain; CCD, coiled-coil domain; CHX, cycloheximide; Co-IP, co-immunoprecipitation; CQ, chloroquine; CTR, control; DAPI, 4′,6-diamidino-2-phenylindole; EBSS, Earle’s balanced salt solution; ECD, evolutionarily conserved domain; EEE, three-tyrosine phosphomimetic mutations Y229E Y233E Y352E; ER, endoplasmic reticulum; FFF, three-tyrosine non-phosphomimetic mutations; FFPE, formalin-fixed paraffin-embedded; FL, full-length; GIST, gastrointestinal stromal tumor; IB, immunoblotting; IHC, immunohistochemistry; KIT-HEK293, KIT stably expressing HEK293 cells; KRT20/CK20, keratin 20; LT, large T-antigen; LT339, MCPyV truncated LT antigen; LTco, codon-optimized MCPyV LT antigen; MCC, Merkel cell carcinoma; MCPyV⁻, MCPyV-negative; MCPyV, Merkel cell polyomavirus; MCPyV⁺, MCPyV-positive; PARP1, poly(ADP-ribose) polymerase 1; PCI, pan-caspase inhibitor; PI, propidium iodide; PtdIns3K, class III phosphatidylinositol 3-kinase; PtdIns3P, phosphatidylinositol-3-phosphate; RB1, RB transcriptional corepressor 1; RTKs, receptor tyrosine kinases; KITLG/SCF, KIT ligand; sT, small T-antigen; sTco, codon-optimized MCPyV sT antigen; T-B, Tat-BECN1; T-S, Tat-scrambled; TEM, transmission electron microscopy.…”