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    The Transition from a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk by Heba M Ismail (9568748)

    Published 2022
    “…This change was mostly attributable to change in the late AUC C-peptide response (i.e., 60-to-120-minute AUC C-peptide). Median Index60 values of  DPT-1 (1.44) and TNPTP (1.05) progressors to type 1 diabetes 1.5 years pre-diagnosis (time of transition from increasing to decreasing AUC C-peptide) were used as thresholds to identify individuals at high risk for type 1 diabetes in the full cohort at baseline (5-year risk of 0.75-0.88 for those above thresholds). …”
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