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marker increased » marked increase (Expand Search), marked increases (Expand Search), care increased (Expand Search)
marked decrease » marked increase (Expand Search)
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The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients.
Published 2020“…In contrast, in <i>APC</i>-mutant tissues from FAP patients, the proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases. Crypt cell levels are indicated that range from crypt bottom (level 1) to crypt top (level ~82). …”
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Aging increases senescence markers in ASM.
Published 2021“…<p>Immunofluorescence staining for p21 a marker of cell cycle arrest (A) showed increased levels in elderly ASM. γH2AX, a marker for DNA damage, increased in elderly ASM (B). …”
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Impaired Ubr5 function results in increased canonical and decreased non-canonical HH signalling.
Published 2021“…<p>Immunohistochemical analysis of six-week-old control and <i>Ubr5</i><sup><i>mt</i></sup> tibial AC examined for markers of canonical HH pathway activity. Relative to (A, C) control, (B, D) <i>Ubr5</i><sup><i>mt</i></sup> AC displayed increased staining intensities for PTCH1 (A, B) and GLI1 (C, D) with GLI1 exhibiting expanded expression domains (D, double-headed arrows). …”
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