TRIT1 MTS-dependent modification of mt-tRNAs in <i>S</i>. <i>pombe</i>. by Abdul Khalique (5029442)

Image1_Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models.jpg by Karthikeyan Selvarasu (14004867)

“…Here, we reported that the kinesin-I heavy chain (KIF5B), a key molecular motor protein, is involved in tau homeostasis in AD cells and animal models. …”

Losartan increased ACE-2 expression, while SARS-CoV-2 spike protein decreased ACE-2 expression in hACE2 brains. by Mackenzi Meier (19251139)

“…Brain homogenate was assessed for ACE-2 expression. a) RT-PCR analysis showing the effect of Losartan and spike protein on ACE-2 gene expression. …”

Position 32 as a determinant of differential IPTase activity for cy-tRNA^TrpCCA in eukaryotes. by Abdul Khalique (5029442)

Overexpression of TNFAIP9 inhibited the TNF-α-induced inflammation in HK-2 cells. by Ying Chen (9697)

Migration rate in human corneal epithelial cell line (HCE-T) (n = 3), human corneal fibroblast (HCF) (n = 5) and human keratoconus fibroblast (KC-HCF) (n = 5) cell cultures, 24 hou... by Ning Chai (394956)

“…<p>Data are expressed as mean ± SEM. 0.17 J/cm² rose bengal photodynamic therapy (RB-PDT) significantly decreased migration rate in all cell types, compared to controls (Ctrl) (p≤0.02). …”

Live imaging of <i>pRPS5A</i>::<i>TagRFP</i>:<i>TUB4</i> tubulin marker during the first and second meiotic division in wild a type plant. by Claudio Capitao (5933654)

GluN2A(D731N) enhances sensitivity to endogenous proton and zinc ions. by Kai Gao (120150)

“…Di-heteromeric (h2A-D731N), one-copy and two-copy mutant tri-heteromeric (D731N/2A and D731N/D731N) receptors show a decreased current ratio, indicating enhanced proton sensitivity. …”

Recombinant α-SNAP halts the AR at a stage when SNAREs are monomeric. by Facundo Rodríguez (213557)

“…<p><i>A</i>, we incubated SLO-permeabilized sperm with 300 nM α-SNAP for 10 min at 37°C followed by 100 nM light chain of TeTx, and 0.5 mM CaCl₂ for an additional 10 min (<i>G</i>, <i>H</i>, <i>I</i>). …”

Changes in mean serum creatine kinase (CK) levels with age. by UnKyu Yun (11177542)

“…(A) Change in mean serum CK level with age for ages 0–12 and (B) change in mean serum CK level with age for ages 12 and above.…”

Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner by Romuald Loutre (5410142)

“…We previously demonstrated that mitochondrial targeting of small RNAs designed to anneal with mutant mtDNA can decrease the heteroplasmy level by specific inhibition of mutant mtDNA replication, thus representing a potential therapy. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

In 5-HTT-/- mice subjected to the WM a low number of NeuroD positive cells is correlated with a poor performance in the Morris water maze. by Margherita M. Karabeg (475186)

“…<p>Applying the Spearman`s test in the quantitative immunohistochemistry study revealed a linear dependence between the learning performance (decreasing learning performance is expressed as increasing area under the learning curve; AuC) and the number of NeuroD-immunoreactive (ir) cells could be found in the temporal hippocampus of 5-HTT-/- WM mice. …”

GluN2A(D731N) reduces the agonist potency. by Kai Gao (120150)

“…<p>(<b>A,B</b>) Representative TEVC recordings obtained from oocytes expressing WT GluN1/GluN2A (WT 2A) receptors (<b>A</b>) and GluN1/GluN2A(D731N) (2A-D731N) receptors (<b>B</b>) in which the currents were evoked by increasing concentrations (μM) of glutamate (in the presence of 100 μM glycine) at the holding potential of -40 mV. …”

Determinants of TRIT1 critical for cy-tRNA^SerUCA-mediated TMS in <i>S</i>. <i>pombe</i>. by Abdul Khalique (5029442)

A higher mean amplitude or lower standard deviation of the EOD of the swimming fish facilitates estimation of beat frequency at the receptor level. by Na Yu (151735)

“…<p>(A) The height (solid line) of the peak of at the beat frequency, , and the width (dashed line) of this peak at the coherence value of 0.15 increase and slightly decrease, respectively, with (with fixed  = 0.1). …”

DECREASE IN OFF-PEAK ELECTRICAL ENERGY DEMAND BY AGROINDUSTRIES DUE TO PHOTOVOLTAIC SOLAR GENERATION by Lucas de A. Viana (7234946)

Overexpression of miR-29a decreased GFAP, a marker of HSC, and increased expression in the acute response to injury and immunoreactivity in cholestasis. by Ying-Hsien Huang (446595)

Scaling exponent α for the whole measuring period 1980–2000 as a function of publication year; numbers are the averages of successive five-years blocks, each five-years block is lo... by Anthony F. J. van Raan (7517696)