Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Discrimination performance deteriorated as the safe-to-conditioned ΔF decreased. by Chi Chen (67021)

Decreased cytokine production by moDCs upon TLR stimulation when preincubated with NSAIDs. by Tonke K. Raaijmakers (13955749)

<i>B. bassiana</i> decreased longevity and impaired climbing. by Deepanshu N. D. Singh (20721878)

Viral replication in obese mice results in decreased genetic diversity. by James Weger-Lucarelli (603766)

Afatinib decreases MAPK and AKT activation after MET knockdown. by Karolin Ebert (7434713)

Data_Sheet_1_Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity.d... by Chantal C. Clark (10684632)

“…</p><p>Conclusion: We observed an association between the use of preexisting thromboprophylaxis and a decreased risk of TE during COVID-19. This suggests that these therapies are beneficial for coping with COVID-19 associated hypercoagulability. …”

RNF5 depletion decreases cellular gene expression and lytic replication through increased EphA3 and EphA4 level in iSLK.219 cells. by Xiaojuan Li (351842)

The m⁶A peak of 3’UTR of TLR4 mRNA decreases significantly in METTL14-knockdown PK-15 cells. by Jing Chen (4762)

AIM-100 reduces dsRNA silencing in body wall muscle and decreases DA neurodegeneration. by Anthony L. Gaeta (13272609)

A summary of the included study characteristics. by Zahra Tajik (20752452)

“…There is no significant difference one month after NSPT in diabetic patients (SMD: -5.83, 95%CI: -15.5, 3.83, p = 0.237, I-square, 97.4%, random effects model, n = 2), but three (SMD: -2.44, 95%CI: -3.37, -1.15, p = 0.001, I-square, 75.9%, random effects model, n = 3) and six months (SMD: -2.41, 95%CI: -3.81, -1.01, p = 0.001, I-square, 78.7%, random effects model, n = 2) after the treatment, a significant decrease is observed in the mean GCF visfatin level. …”

<b>When more isn’t better: Sperm competition decreases fertilization success and motile sperm in two sea urchin species</b> by Luisa Kumpitsch (20874095)

“…<p dir="ltr">Abstract of the paper "<b>When more isn’t better: Sperm competition decreases fertilization success and motile sperm in two sea urchin species":</b></p><p dir="ltr">Fertilization is a fundamental process where sperm-egg fusion is essential to maintain life of most metazoans. …”

DataSheet2_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.pdf by Sunil Veeravalli (5074115)

“…<p>We previously showed that Fmo5^−/− mice exhibit a lean phenotype and slower metabolic ageing. …”

DataSheet1_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.PDF by Sunil Veeravalli (5074115)

“…<p>We previously showed that Fmo5^−/− mice exhibit a lean phenotype and slower metabolic ageing. …”

Table_1_Cysteinyl Leukotriene Receptor Antagonists Associated With a Decreased Incidence of Cancer: A Retrospective Cohort Study.docx by Ha Young Jang (1522204)

“…</p>Conclusion<p>In this study, we found that LTRA use was associated with a decreased risk of cancer. …”

ND-75^KD flies have reduced mobility, seizures and decreased lifespan. by Lucy Granat (5570813)

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity by Qin Huang (49441)

Subjects:

Image_1_Prediabetes: Adherence to Nutrition Visits Decreases HbA1c in Children and Adolescents.tiff by Sadichchha Parajuli (11716967)

EMS decreases female fecundity and <i>Wolbachia</i> titre in the next generation in a dose-dependent manner. by Elves H. Duarte (10994504)