Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs حسب Michael J. Cunningham (14267038)

"…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …"

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs حسب Michael J. Cunningham (14267038)

"…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …"

Viral replication in obese mice results in decreased genetic diversity. حسب James Weger-Lucarelli (603766)

Data_Sheet_1_Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity.d... حسب Chantal C. Clark (10684632)

"…</p><p>Conclusion: We observed an association between the use of preexisting thromboprophylaxis and a decreased risk of TE during COVID-19. This suggests that these therapies are beneficial for coping with COVID-19 associated hypercoagulability. …"

HVR1-swap compensatory E1/E2 substitutions typically decrease virus entry dependency on SR-BI. حسب Christina Holmboe Olesen (11154333)

DataSheet2_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.pdf حسب Sunil Veeravalli (5074115)

"…<p>We previously showed that Fmo5^−/− mice exhibit a lean phenotype and slower metabolic ageing. …"

DataSheet1_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.PDF حسب Sunil Veeravalli (5074115)

"…<p>We previously showed that Fmo5^−/− mice exhibit a lean phenotype and slower metabolic ageing. …"

Table_1_Cysteinyl Leukotriene Receptor Antagonists Associated With a Decreased Incidence of Cancer: A Retrospective Cohort Study.docx حسب Ha Young Jang (1522204)

"…</p>Conclusion<p>In this study, we found that LTRA use was associated with a decreased risk of cancer. …"

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity حسب Qin Huang (49441)

الموضوعات:

Impaired Ubr5 function results in increased canonical and decreased non-canonical HH signalling. حسب David Mellis (2833469)

I348T increases H77 entry dependency on SR-BI, while T385P decreases H77 entry dependency on SR-BI. حسب Christina Holmboe Olesen (11154333)

MBOAT7 rs641738 (C>T) is associated with NAFLD progression and decreased ASCVD risk in elder Chinese population حسب Zhang jing (14062485)

B-factor values of Ca_V3.3 M1425 substitutions. حسب Yousra El Ghaleb (22075892)

الموضوعات:

Mitochondrial protein acetylation correlates with a decrease in sirtuin 3 levels. حسب Mercedes García-Roche (6459200)

DataSheet_1_A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes.pdf حسب Snehaa V. Seal (12587992)

Image_5_Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.TIF حسب Tomohiro Takano (9227690)

Image_5_v1_Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.jpeg حسب Casey E. Vantucci (10528263)

"…This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. …"

Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom <i>Thalassiosira pseudonana</i> حسب Johanna A. L. Goldman (7372724)

The introduction of mutualisms into assembled communities increases their connectance and complexity while decreasing their richness. حسب Gui Araujo (22170819)

"…(C) Mutualism also promotes an increase in network connectance when introduced into assembled communities, while stopping mutualistic interactions from entering an assembled system slowly decreases it. (D) As a result, the introduction of mutualistic interactions promotes a growth in complexity in communities where it was once established as low, while stopping the introduction of further mutualistic interactions causes a slight decrease in complexity. …"

Crosslinking decreases the alignment of fibers associated with individual cells migrating out of spheroids. حسب Michael Pamonag (12295175)