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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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846
Contrasting cardiovascular mortality trends in Eastern Mediterranean populations: Contributions from risk factor changes and treatments
Published 2016“…Background Middle income countries are facing an epidemic of non-communicable diseases, especially coronary heart disease (CHD). …”
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847
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848
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849
Bioactive Components from Ginger, Tea and Apple Prevent Protein Glycation by Trapping Methylglyoxal with Potential in Alleviation of Diabetic Complications
Published 2016“…In diabetes, formation of AGEs occurs at a higher rate when compared to non-diabetic normal individuals. …”
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850
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851
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Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome.
Published 2020“…This study is expected to serve as a platform for developing targeted drug therapy for BS.…”
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853
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854
Specific Bioactive Compounds from Ginger, Tea, and Apple Prevent Diabetes-Related Cataract Via Inhibition of Aldose Reducatse
Published 2016“…Results show that cell viability decreased to 93 ± 3%, 83 ± 6%, 65 ± 4% and 39 ± 3% at 10, 25, 50 and 100 mM of glucose on day 1 with further drastic decrease in cell viability to 73 ± 5%, 61 ± 3%, 35 ± 2%, and 11 ± 6%, respectively, on day 4 compared to the untreated cell. …”
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855
Response of cauliflower (Brassica oleracea L.) to nitric oxide application under cadmium stress
Published 2022“…Our results illustrated that the increasing levels of Cd in the sand, significantly (P < 0.05) decreased shoot length, root length, shoot fresh weight, root fresh weight, shoot dry weight, root dry weight, germination percentage, germination index, mean germination time, time to 50% germination, chlorophyll a, chlorophyll b, total chlorophyll and carotenoid contents in all genotypes of B. oleracea. …”
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856
An Improved Genghis Khan Optimizer based on Enhanced Solution Quality Strategy for Global Optimization and Feature Selection Problems
Published 2024“…However, these methods tend to converge towards local solutions with a low convergence rate. In order to address this issue in GKSO, a more refined version called I-GKSO is implemented. …”
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857
Experimental investigation on the compressibility of Al/Al2O3 nanocomposites
Published 2016“…The results showed that the grain size of milled powders was about 43 nm with a noticeable presence of agglomerates at 10 wt.% of Al2O3. …”
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858
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PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
Published 2017“…Glioblastoma (GBM) represents the most common and aggressive histologic subtype among malignant astrocytoma and is associated with poor outcomes because of heterogeneous tumour cell population including mature non-stem-like cell and immature stem-like cells within the tumour. …”
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