Data Sheet 1_Integrative transcriptome and WGCNA analysis reveal key genes mainly in response to Alternaria alternata in Populus simonii × P. nigra.docx by Siyuan Liu (696701)

“…<p>In order to explore the molecular mechanisms of Populus simonii × P. nigra response to stress and screen for genes conferring resistance to Alternaria alternata, we carried out measurements of physiological and biochemical indices and transcriptomic sequence analysis of leaves of Populus simonii × P. nigra inoculated with A. alternata. The results showed that the variation trends of multiple hormone contents and enzyme activities were broadly similar at different time points, with H₂O₂, SA, JA, PPO, SOD, PAL and POD showing a trend of increasing and then decrease after inoculation with the pathogen. …”

Table 1_Integrative transcriptome and WGCNA analysis reveal key genes mainly in response to Alternaria alternata in Populus simonii × P. nigra.xlsx by Siyuan Liu (696701)

“…<p>In order to explore the molecular mechanisms of Populus simonii × P. nigra response to stress and screen for genes conferring resistance to Alternaria alternata, we carried out measurements of physiological and biochemical indices and transcriptomic sequence analysis of leaves of Populus simonii × P. nigra inoculated with A. alternata. The results showed that the variation trends of multiple hormone contents and enzyme activities were broadly similar at different time points, with H₂O₂, SA, JA, PPO, SOD, PAL and POD showing a trend of increasing and then decrease after inoculation with the pathogen. …”

Volcano plots. by Joe L. Webb (9596478)

“…<p>Genes upregulated (green) or downregulated (red) by WE consumption, correspond to a 1.5 decrease or increase in log fold changes. …”

Kinase activity. by James W. Bruce (10204626)

“…<p>Kinase activities from the phosphorylation log2 fold changes at 5 min using PhosFate Profiler. PhosFate Profiler computes an enrichment score for kinases using the Kolmogorov–Smirnov statistical test, a p-value, and a kinase activity, where a positive score indicates an increase and a negative score a decrease in kinase activity.…”

Nuclear progestin receptor is up-regulated by estrogen in both the developing and adult brain. by Nicolas Diotel (338556)

“…In A, the aromatase inhibitor (ATD) leads to a significant decrease of <i>pgr</i> expression in individual brains of adult zebrafish (n = 4). …”

Death-related down-regulated expression changes in WR99210-treated parasites. by Karthikeyan Ganesan (269200)

“…Twenty one genes showed a drug-dependent decrease in gene expression (see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000214#ppat.1000214.s009" target="_blank">Table S5</a> for PlasmoDB gene number).…”

Metabolic capacity of synaptosomes. by Ernst-Bernhard Kayser (2172865)

“…The only significant (α = 5%) change observed was a decrease with age in the controls (*) from cerebellum. …”

Repression of miR-29 during outlet obstruction is associated with increased levels of miR-29 target messenger RNAs (mRNAs). by Mari Ekman (168258)

“…(B) Time courses of mRNA expression for six confirmed miR-29c targets (official symbols are given in the legend). Fold changes are versus sham. (C) Correlation between miR-29c and the mean fold change of the target mRNAs depicted in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082308#pone-0082308-g003" target="_blank">Figure 3B</a>. …”

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus by Yun Deng (67804)

“…<i>TLR7</i> 3′UTR sequence bearing the non-risk C allele of rs3853839 matches a predicted binding site of microRNA-3148 (miR-3148), suggesting that this microRNA may regulate <i>TLR7</i> expression. …”

Overexpression of <i>lprG-rv1410c</i> increases TAG released into culture medium of broth-cultured cells. by Amanda J. Martinot (398601)

“…Lower panel, OE vs. Mut2 total cells (12.5 μg lipid); 2-fold decrease, corrected p< 0.05 (blue), TAG (yellow overlay). …”

An AICD-based functional screen to identify APP metabolism regulators-4 by Can Zhang (56016)

AR-mediated transcriptional regulation of apoptotic genes in HPr-1AR. by Congcong Chen (796149)

“…The color intensity reflects the relative fold change (brightest red = 4-fold increase and brightest green = 4-fold decrease) in transcript level for DHT- versus vehicle control (CTL)-treated cells (n = 3). …”

Anterior blind area of the avian visual field. by Luke P. Tyrrell (3320895)

“…If the head width is held constant, then a two-fold increase in the binocular field width results in a five-fold decrease in blind gap length. …”

Sam_Otos.csv from High dispersal rates in hybrids drive expansion of maladaptive hybridization by Samuel L. Bourret (13997720)

“…Here, we test if non-native genetic introgression increases reproductive dispersal using a human-mediated hybrid zone between native cutthroat trout (<i>Oncorhynchus clarkii</i>) and invasive rainbow trout (<i>Oncorhynchus mykiss</i>) in a large and connected river system. …”

QuantitativeStrayAssignment.R from High dispersal rates in hybrids drive expansion of maladaptive hybridization by Samuel L. Bourret (13997720)

“…Here, we test if non-native genetic introgression increases reproductive dispersal using a human-mediated hybrid zone between native cutthroat trout (<i>Oncorhynchus clarkii</i>) and invasive rainbow trout (<i>Oncorhynchus mykiss</i>) in a large and connected river system. …”

Determinant of Selective Removal (DSR) sequences can reduce protein levels expressed from P<i>_urg1lox</i>. by Adam T. Watson (500083)

“…Induced cell total protein extracts were used to estimate the fold-decrease in protein levels after induction. …”

DNA2 has distinct effects on Alt-EJ and end resection, compared to FANCA and PARP. by Sean M. Howard (687174)

“…(<b>B)</b> PARPi treatment and DNA2 depletion cause an approximately additive decrease in Alt-EJ. U2OS EJ2-GFP cells were treated with siCTRL or siDNA2–4 prior to expression of I-SceI and treatment with 5 μM Olaparib (Olap) or vehicle (DMSO). …”

Triple-combination therapy for cutaneous leishmaniasis using detergent-free, hyaluronate-coated elastic nanovesicles - Supplementary data set by Kashif Iqbal (6504587)

“…Materials & methods: H-ENVs were</p> <p>developed and evaluated for vesicle size, entrapment efficiency, skin permeation and antileishmanial</p> <p>potential. Results: A 15.7 and 28.6% decrease in the cytotoxicity of paromomycin and amphotericin B,</p> <p>respectively, was observed in detergent-free ENVs compared with conventional ENVs. …”

Supplemental material for Fig 1. by Hannah Gordon (8729760)

“…(p) Quantification of the area of microglia during cell death event from 4 to 5 dpf. (q, r) Confocal images of <i>Tg(pu1</i>:<i>GFP)</i> animals (q) and quantifications of microglia abundance (r) at time point 0 h and 24 h from a 24-h time lapse and non-time lapsed animals demonstrating that the number of microglia is not impacted by 24-h time lapses. …”

Activity of metalloproteinases in the adult gerbil hippocampus after global ischemia. by Luiza Wójcik-Stanaszek (347531)

“…<p>Animals were subjected to 5 min of global forebrain ischemia followed by reperfusion. …”