Phase 2b study of evocalcet (KHK7580), a novel calcimimetic, in Japanese patients with secondary hyperparathyroidism undergoing hemodialysis: A randomized, double-blind, placebo-co... by Tadao Akizawa (316095)

“…Adverse events were observed in 30%–50% of patients (all groups). Incidence of adverse events was similar among all groups except for decreased calcium, which occurred more frequently in the evocalcet 2 mg and cinacalcet groups.…”

Winter Conditions and Land Cover Structure the Subnivium, A Seasonal Refuge beneath the Snow by Sonia K. Petty (746990)

Growth of certain cancer cell lines requires IRE1 but not its enzymatic activity. by Iratxe Zuazo-Gaztelu (21071939)

Weighted size (kDa) of RNase A, RNase B, and DNase I. by Tonya M. Santaus (5559077)

Desensitization and treatment with APRIL/BLyS blockade in rodent kidney transplant model by Natalie M. Bath (6316517)

“…Sensitized animals treated with APRIL/BLyS blockade demonstrated a significant decrease in marginal zone non-switched B lymphocyte populations (p<0.01). …”

Image_5_A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial.TIF by Stephan Thurau (10213218)

“…There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. …”

Image_2_A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial.TIF by Stephan Thurau (10213218)

“…There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. …”

Image_6_A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial.TIF by Stephan Thurau (10213218)

“…There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. …”

Image_1_A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial.TIF by Stephan Thurau (10213218)

“…There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. …”

Image_3_A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial.TIF by Stephan Thurau (10213218)

“…There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. …”

Image_4_A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial.TIF by Stephan Thurau (10213218)

“…There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. …”

Normalized (relative to maximum = 100%) knee extensor forces as a function of time. by Ziad Abusara (848106)

“…(b) 50% of muscular loading (n = 7), the cartilage-on-cartilage space reached zero and cartilage thickness decreased for these loading conditions. …”

Lack of oligodendrocytes after DTA-mediated ablation of <i>C1ql1</i>-expressing OPCs. by Shayan Moghimyfiroozabad (19066182)

“…Scale bars = 100 μm. Quantification shows a massive decrease in OL density in the <i>C1ql1</i>^<i>pos</i> OPC-ablated brains. …”

The mechanism for pattern convergence and divergence requires a high-threshold transfer function. by Gaia Tavoni (5451656)

The S-DNA produced in the B-to-S transition does not promote RecA nucleoprotein filament formation. by Hongxia Fu (423266)

“…<p>(A) Time traces of the extension of an 876 bp DNA tether with two GC-rich ends recorded during B-to-S transition in force-increase scan and the reverse S-to-B transition in the subsequent force-decrease scan in 50 mM KCl, 10 mM MgCl₂, pH 7.4, at 24°C. …”

Example of wavenumbers with strong effects in predicting fibrotic grade. by Ramie N. Ali-Adeeb (14312055)

Model of starvation adaptation controlled by the RNA exosome. by Xi Feng (469632)

ZC3H32 is essential in bloodstream-form trypanosomes. by Cornelia Klein (784965)

Saccharomyces complexes. by Matthew J. O’Meara (1659064)

“…<div><p>Elucidating gene function is a major goal in biology, especially among non-model organisms. …”

cluster analysis. by Matthew J. O’Meara (1659064)

“…<div><p>Elucidating gene function is a major goal in biology, especially among non-model organisms. …”